RalA downstream regulated genes (WP2290)

Homo sapiens

Downstream genes of RalA signaling pathways, including the Rac-family GTPase-activating protein RLIP (also known as RLIP76 and ralA binding protein 1 (RALBP1)), CDC42(cell division cycle 42), RAC1 (ras-related C3 botulinum toxin substrate 1), RAC2, RAC3, the Y-box transcription factor ZO-1-associated nucleic acidbinding protein (ZONAB, also known as cold shock domain protein A (CSDA)), and two subunits of the exocyst complex, SEC5 (also known as exocyst complex component 2 (EXOC2)) and EXO84 (also known as EXOC8), which are involved in regulating cell proliferation, apoptosis and migration

Authors

Martina Summer-Kutmon , Daniela Digles , and Zahra Roudbari

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

Ras family mediated signaling pathway

Disease Ontology

chronic myeloid leukemia

Participants

Label Type Compact URI Comment
ZONAB GeneProduct ncbigene:8531
SEC5 GeneProduct ncbigene:55770
EXOC84 GeneProduct ncbigene:149371
RALBP1 GeneProduct ncbigene:10928
CDC42 GeneProduct ncbigene:998
RAC3 GeneProduct ncbigene:5881
RAC2 GeneProduct ncbigene:5880
RAC1 GeneProduct ncbigene:5879
HRAS GeneProduct ncbigene:3265
KRAS GeneProduct ncbigene:3845
NRAS GeneProduct ncbigene:4893
RalA GeneProduct ncbigene:5898

References

  1. miR-181a post-transcriptionally downregulates oncogenic RalA and contributes to growth inhibition and apoptosis in chronic myelogenous leukemia (CML). Fei J, Li Y, Zhu X, Luo X. PLoS One. 2012;7(3):e32834. PubMed Europe PMC Scholia