Cell cycle (WP190)

Mus musculus

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The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell’s progress through the cell cycle. From Wikipedia Cell Cycle.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Nathan Salomonis , Bruce Conklin , Martijn Van Iersel , Christine Chichester , Martina Summer-Kutmon , and Egon Willighagen

Activity

last edited

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

cell cycle pathway, mitotic

Participants

Label Type Compact URI Comment
Cdc7 GeneProduct ncbigene:12545 CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
Cdc25c GeneProduct ncbigene:12532 CDC25C; cell division cycle 25C [EC:3.1.3.48]
Wee1 GeneProduct ncbigene:22390 WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
Cdh1 GeneProduct ncbigene:12550
Hdac4 GeneProduct ncbigene:208727 «208727[L] »
Hdac4; histone deacetylase 4
Tgfb1 GeneProduct ncbigene:21803
Cdc25b GeneProduct ncbigene:12531 CDC25B; cell division cycle 25B [EC:3.1.3.48]
Mcm2 GeneProduct ncbigene:17216 MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae
Pkmyt1 GeneProduct ncbigene:268930 PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
Cdk4 GeneProduct ncbigene:12567 CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
Cdkn1a GeneProduct ncbigene:12575 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
Ccnb2 GeneProduct ncbigene:12442 CCNB2; cyclin B2
Chek1 GeneProduct ncbigene:12649 CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
Ccnd3 GeneProduct ncbigene:12445 CCND3; cyclin D3
Hdac6 GeneProduct ncbigene:15185 HDAC6; histone deacetylase 6
Cdk2 GeneProduct ncbigene:12566 CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
E2f6 GeneProduct ncbigene:50496 E2F6; E2F transcription factor 6
Mad2l2 GeneProduct ncbigene:71890 MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
Pttg1 GeneProduct ncbigene:30939 PTTG1; pituitary tumor-transforming
Rbl1 GeneProduct ncbigene:19650
AA545217 GeneProduct ncbigene:27214 ASK; activator of S phase kinas
E2f2 GeneProduct ncbigene:242705 E2F2; E2F transcription factor 2
Hdac1 GeneProduct ensembl:ENSMUSG00000028800 HDAC1; histone deacetylase 1
Orc1l GeneProduct ncbigene:18392 ORC1L; origin recognition complex subunit 1-like (yeast)
Mad2l1 GeneProduct ncbigene:56150 MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
E2f4 GeneProduct ncbigene:104394 E2F4; E2F transcription factor 4 p107/p130-binding
Mcm6 GeneProduct ncbigene:17219 MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae)
Hdac3 GeneProduct ncbigene:15183 HDAC3; histone deacetylase 3
Rbl1 GeneProduct ncbigene:19650 RBL1; retinoblastoma-like 1 (p107)
Rb1 GeneProduct ncbigene:19645 RB1; retinoblastoma 1 (including osteosarcoma)
Prkdc GeneProduct ncbigene:19090 PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
Ccnh GeneProduct ncbigene:66671 CCNH; cyclin H
Orc6l GeneProduct ncbigene:56452 ORC6L; origin recognition complex subunit 6-like (yeast)
Smc1l2 GeneProduct ncbigene:140557 SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
Ccna1 GeneProduct ncbigene:12427 CCNA1; cyclin A1
Pcna GeneProduct ncbigene:18538 PCNA; proliferating cell nuclear antigen
Smad3 GeneProduct ncbigene:17127 MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
Cdkn1b GeneProduct ncbigene:12576
Hdac7a GeneProduct ncbigene:56233 HDAC7A; histone deacetylase 7
Cdk6 GeneProduct ncbigene:12571 CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
Skp2 GeneProduct ncbigene:27401 SKP2; S-phase kinase-associated protein 2 (p45
Orc3l GeneProduct ncbigene:50793 ORC3L; origin recognition complex subunit 3-like (yeast)
Mcm5 GeneProduct ncbigene:17218 MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae)
Cdc25a GeneProduct ncbigene:12530 CDC25A; cell division cycle 25A [EC:3.1.3.48]
Ccnb3 GeneProduct ncbigene:209091 CCNB3; cyclin B - see SP:Q8VDC5
Chek2 GeneProduct ncbigene:50883 CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
Mdm2 GeneProduct ncbigene:17246 MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
Ccnd2 GeneProduct ncbigene:12444 CCND2; cyclin D2
Ep300 GeneProduct ncbigene:328572 EP300; E1A binding protein p300
Abl1 GeneProduct ncbigene:11350 ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
Mad1l1 GeneProduct ncbigene:17120 MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
Espl1 GeneProduct ncbigene:105988 ESPL1; extra spindle poles like 1 (S. cerevisiae
Ccna2 GeneProduct ncbigene:12428 CCNA2; cyclin A2
Gsk3b GeneProduct ncbigene:56637 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
Tfdp1 GeneProduct ncbigene:21781 TFDP1; transcription factor Dp-1
Cdc2a GeneProduct ncbigene:12534 CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
Mcm4 GeneProduct ncbigene:17217 MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae
Cdc14B GeneProduct ncbigene:218294 CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
Bub1 GeneProduct ncbigene:12235 BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
Ccne1 GeneProduct ncbigene:12447 CCNE1; cyclin E
Hdac2 GeneProduct ncbigene:15182 HDAC2; histone deacetylase 2
Bub1b GeneProduct ncbigene:12236 BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
Tbc1d8 GeneProduct ncbigene:54610
Bub3 GeneProduct ncbigene:12237 BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
Cdc45l GeneProduct ncbigene:12544 CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
Ywhag GeneProduct ncbigene:22628 YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid
E2f3 GeneProduct ncbigene:13557 E2F3; E2F transcription factor 3
Hdac5 GeneProduct ncbigene:15184 HDAC5; histone deacetylase 5
Ccne2 GeneProduct ncbigene:12448 CCNE2; cyclin E
Orc4l GeneProduct ncbigene:26428 ORC4L; origin recognition complex subunit 4-like (yeast)
Orc2l GeneProduct ncbigene:18393 ORC2L; origin recognition complex subunit 2-like (yeast)
Gadd45a GeneProduct ncbigene:13197
Mcm3 GeneProduct ncbigene:17215 MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
AL118125 GeneProduct ncbigene:404565 «208727[L] »
Hdac4; histone deacetylase 4
Cdkn2a GeneProduct ncbigene:12578
Trp53 GeneProduct ncbigene:22059
E2f1 GeneProduct ncbigene:13555 E2F1; E2F transcription factor 1
Ccnb1 GeneProduct ncbigene:268697
Atm GeneProduct ncbigene:11920 ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
Smad4 GeneProduct ncbigene:17128 MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
Plk1 GeneProduct ncbigene:18817 PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
Cdc14A GeneProduct ncbigene:229776 CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
E2f5 GeneProduct ncbigene:13559 E2F5; E2F transcription factor 5 p130-binding
Mcm7 GeneProduct ncbigene:17220 MCM7; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
Mpeg1 GeneProduct ncbigene:17476
Cdc20 GeneProduct ncbigene:107995 CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
Orc5l GeneProduct ncbigene:26429 ORC5L; origin recognition complex subunit 5-like (yeast)
Cdc6 GeneProduct ncbigene:23834 CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
Atr GeneProduct ncbigene:245000 ATR; ataxia telangiectasia and Rad3 related

References