Adipogenesis (WP155)

Rattus norvegicus

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The different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, composed of white and brown adipose tissue, is composed of adipocytes. This pathway is primarily studied to understand factors that contribute to obesity and diabetes. Transcriptional and hormonal regulators of adipocyte formation are indicated.

Authors

Mary-Elizabeth Patti , Martijn Van Iersel , and Martina Summer-Kutmon

Activity

last edited

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Cited In

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

signaling pathway pertinent to development

Participants

Label Type Compact URI Comment
Igf1 GeneProduct ncbigene:24482
Ptgis GeneProduct ncbigene:25527
Ppard GeneProduct ncbigene:25682
Creb1 GeneProduct ncbigene:81646
Mixl1 GeneProduct ncbigene:289311
GH1 GeneProduct ncbigene:24391
Id3 GeneProduct ncbigene:25585
Wnt10b GeneProduct ncbigene:315294
Stat5a GeneProduct ncbigene:24918
Stat5b GeneProduct ncbigene:25126
Dlk1 GeneProduct ncbigene:114587
Nr3c1 GeneProduct ncbigene:24413
Ddit3 GeneProduct ncbigene:29467
Lif GeneProduct ncbigene:60584
Cebpb GeneProduct ncbigene:24253
Cyp26a1 GeneProduct ncbigene:154985
Cyp26b1 GeneProduct ncbigene:312495
Rxra GeneProduct ncbigene:25271
Rara GeneProduct ncbigene:24705
Nr1h3 GeneProduct ncbigene:58852
Lpl GeneProduct ncbigene:24539
Srebf1 GeneProduct ncbigene:78968
Fas GeneProduct ncbigene:246097
Rbl1 GeneProduct ncbigene:680111
Gata3 GeneProduct ncbigene:85471
Gata2 GeneProduct ncbigene:25159
Pparg GeneProduct ncbigene:25664
MEF2A GeneProduct ncbigene:309957
MEF2B GeneProduct ncbigene:498607
Mef2c GeneProduct ncbigene:499497
Mef2d GeneProduct ncbigene:81518
Asip GeneProduct ncbigene:24152
Tnf GeneProduct ncbigene:24835
Mif GeneProduct ncbigene:81683
Tgfb1 GeneProduct ncbigene:59086
Serpine1 GeneProduct ncbigene:24617
Slc2a4 GeneProduct ncbigene:25139
Scd1 GeneProduct ncbigene:246074
Twist1 GeneProduct ncbigene:85489
Lep GeneProduct ncbigene:25608
Retn GeneProduct ncbigene:246250
Cfd GeneProduct ncbigene:54249
GTF3A GeneProduct ncbigene:246299
Rb1 GeneProduct ncbigene:24708
Rbl2 GeneProduct ncbigene:81758
Adipoq GeneProduct ncbigene:246253
Adfp GeneProduct ncbigene:298199
Agt GeneProduct ncbigene:24179
Cdkn1a GeneProduct ncbigene:114851
E2f1 GeneProduct ncbigene:399489
Sp1 GeneProduct ncbigene:24790
Hmga1 GeneProduct ncbigene:117062
Plin GeneProduct ncbigene:25629
Il6 GeneProduct ncbigene:24498
Gadd45a GeneProduct ncbigene:25112
Gadd45b GeneProduct ncbigene:299626
CEBPD GeneProduct ncbigene:25695
Bmp1 GeneProduct ncbigene:83470
Bmp2 GeneProduct ncbigene:29373
Bmp3 GeneProduct ncbigene:25667
Bmp4 GeneProduct ncbigene:25296
Ndn GeneProduct ncbigene:308690
Foxo1 GeneProduct ncbigene:84482
Klf5 GeneProduct ncbigene:84410
FOXC2 GeneProduct ncbigene:171356
Ppargc1a GeneProduct ncbigene:83516
Ncoa1 GeneProduct ncbigene:313929
Ncoa2 GeneProduct ncbigene:83724
Ppara GeneProduct ncbigene:25747
Stat3 GeneProduct ncbigene:25125
Stat2 GeneProduct ncbigene:288774
Stat1 GeneProduct ncbigene:25124
Stat6 GeneProduct ncbigene:362896
Socs1 GeneProduct ncbigene:252971
Socs3 GeneProduct ncbigene:89829
Cntfr GeneProduct ncbigene:313173
Lifr GeneProduct ncbigene:81680
Il6st GeneProduct ncbigene:25205
Mbnl1 GeneProduct ncbigene:282635
Osm GeneProduct ncbigene:289747
Ctnnb1 GeneProduct ncbigene:84353
Ucp1 GeneProduct ncbigene:24860
Wnt5b GeneProduct ncbigene:282582
Wnt1 GeneProduct ncbigene:24881
Smad3 GeneProduct ncbigene:25631
Fzd1 GeneProduct ncbigene:58868
Dvl1 GeneProduct ncbigene:83721
Hnf1a GeneProduct ncbigene:24817
Rxrg GeneProduct ncbigene:83574
Frzb GeneProduct ncbigene:295691
Ins2 GeneProduct ncbigene:24506
Nampt GeneProduct ncbigene:297508
Spock1 GeneProduct ncbigene:306759
Trib3 GeneProduct ncbigene:246273
Gata4 GeneProduct ncbigene:54254
Nr2f1 GeneProduct ncbigene:81808
Nrip1 GeneProduct ncbigene:304157
Rora GeneProduct ncbigene:300807
Prlr GeneProduct ncbigene:24684
Pnpla3 GeneProduct ncbigene:362972
Cugbp1 GeneProduct ncbigene:362160
Hif1a GeneProduct ncbigene:29560
Klf6 GeneProduct ncbigene:58954
Klf7 GeneProduct ncbigene:363243
Sfrp4 GeneProduct ncbigene:89803
NCOR1 GeneProduct ncbigene:54299
Ncor2 GeneProduct ncbigene:360801
Klf15 GeneProduct ncbigene:85497
Egr2 GeneProduct ncbigene:114090
Ebf1 GeneProduct ncbigene:116543
Epas1 GeneProduct ncbigene:29452
Ahr GeneProduct ncbigene:25690
Cisd1 GeneProduct ncbigene:294362
Wwtr1 GeneProduct ncbigene:295062
Gdf10 GeneProduct ncbigene:79216
Irs1 GeneProduct ncbigene:25467
IRS4 GeneProduct ncbigene:315350
Bscl2 GeneProduct ncbigene:361722
Lmna GeneProduct ncbigene:60374
Agpat2 GeneProduct ncbigene:311821
Zmpste24 GeneProduct ncbigene:313564
Lpin1 GeneProduct ncbigene:313977
Lpin2 GeneProduct ncbigene:316737
Lipe GeneProduct ncbigene:25330
Pck1 GeneProduct ncbigene:362282
Pck2 GeneProduct ncbigene:361042
Cebpa GeneProduct ncbigene:24252
Irs2 GeneProduct ncbigene:29376
Lpin3 GeneProduct ncbigene:362261
E2F4 GeneProduct ncbigene:307794

References

  1. Molecular regulation of adipogenesis. Rosen ED, Spiegelman BM. Annu Rev Cell Dev Biol. 2000;16:145–71. PubMed Europe PMC Scholia