Apoptosis (WP1351)

Danio rerio

Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.

Authors

Martijn Van Iersel , Kristina Hanspers , Martina Summer-Kutmon , and Levi Wackers

Activity

last edited

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Organisms

Danio rerio

Communities

Annotations

Pathway Ontology

regulatory pathway

Participants

Label Type Compact URI Comment
casp9 GeneProduct ensembl:ENSDARG00000004325 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:842
mdm2 GeneProduct ensembl:ENSDARG00000033443 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4193
traf3 GeneProduct ensembl:ENSDARG00000022000 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7187
txndc15 GeneProduct ensembl:ENSDARG00000043249 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3659
nfkb1 GeneProduct ensembl:ENSDARG00000105261 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4790
fas GeneProduct ensembl:ENSDARG00000043586 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:355
birc2 GeneProduct ensembl:ENSDARG00000044619 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:329
diabloa GeneProduct ensembl:ENSDARG00000104172 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:56616
akt1 GeneProduct ensembl:ENSDARG00000099657 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:207
si:ch211-165b19.5 GeneProduct ensembl:ENSDARG00000055986 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3002
tnfrsf21 GeneProduct ensembl:ENSDARG00000001807 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:27242
bada GeneProduct ensembl:ENSDARG00000087993 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:572
nfkbiab GeneProduct ensembl:ENSDARG00000007693 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4792
zgc:171731 GeneProduct ensembl:ENSDARG00000014657 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:834
ripk1l GeneProduct ensembl:ENSDARG00000006677 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8737
irf2a GeneProduct ensembl:ENSDARG00000007387 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3660
nfkbib GeneProduct ensembl:ENSDARG00000030087 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4793
tnfb GeneProduct ensembl:ENSDARG00000013598 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4049
zgc:171731 GeneProduct ensembl:ENSDARG00000014657 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:837
irf6 GeneProduct ensembl:ENSDARG00000101986 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3664
casp3b GeneProduct ensembl:ENSDARG00000055045 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:836
prf1.2 GeneProduct ensembl:ENSDARG00000021444 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5551
tnfrsf1a GeneProduct ensembl:ENSDARG00000018569 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7132
igf1ra GeneProduct ensembl:ENSDARG00000027423 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3480
rela GeneProduct ensembl:ENSDARG00000098696 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5970
chuk GeneProduct ensembl:ENSDARG00000011662 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1147
BX511080.1 GeneProduct ensembl:ENSDARG00000089995 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:581
apaf1 GeneProduct ensembl:ENSDARG00000021239 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:317
tnfrsf1b GeneProduct ensembl:ENSDARG00000070165 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7133
birc2 GeneProduct ensembl:ENSDARG00000044619 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:330
si:ch211-112c15.8 GeneProduct ensembl:ENSDARG00000089868 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8718
mapk10 GeneProduct ensembl:ENSDARG00000102730 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5602
traf1 GeneProduct ensembl:ENSDARG00000069482 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7185
ikbkb GeneProduct ensembl:ENSDARG00000079123 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3551
irf5 GeneProduct ensembl:ENSDARG00000045681 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3663
dffa GeneProduct ensembl:ENSDARG00000055770 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1676
cycsa GeneProduct ensembl:ENSDARG00000095636 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:54205
irf3 GeneProduct ensembl:ENSDARG00000076251 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3661
casp2 GeneProduct ensembl:ENSDARG00000062052 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:835
tp73 GeneProduct ensembl:ENSDARG00000017953 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7161
scaf11 GeneProduct ensembl:ENSDARG00000045885 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9169
casp7 GeneProduct ensembl:ENSDARG00000091836 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:840
myca GeneProduct ensembl:ENSDARG00000045695 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4609
tnfb GeneProduct ensembl:ENSDARG00000013598 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7124
igf2a GeneProduct ensembl:ENSDARG00000018643 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3481
cradd GeneProduct ensembl:ENSDARG00000028192 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8738
ikbkg GeneProduct ensembl:ENSDARG00000017037 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8517
boka GeneProduct ensembl:ENSDARG00000052129 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:666
unm_sa808 GeneProduct ensembl:ENSDARG00000078378 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7186
cflara GeneProduct ensembl:ENSDARG00000055966 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8837
pik3r1 GeneProduct ensembl:ENSDARG00000038524 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5295
tradd GeneProduct ensembl:ENSDARG00000036057 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8717
birc5a GeneProduct ensembl:ENSDARG00000075621 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:332
igf1 GeneProduct ensembl:ENSDARG00000094132 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3479
tnfrsfa GeneProduct ensembl:ENSDARG00000004451 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8795
jun GeneProduct ensembl:ENSDARG00000043531 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3725
bnip3la GeneProduct ensembl:ENSDARG00000025468 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:665
dffb GeneProduct ensembl:ENSDARG00000009748 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1677
bcl2a GeneProduct ensembl:ENSDARG00000094704 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:596
irf7 GeneProduct ensembl:ENSDARG00000045661 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3665
bcl2l1 GeneProduct ensembl:ENSDARG00000008434 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:598
irf4b GeneProduct ensembl:ENSDARG00000055374 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3662
nfkbie GeneProduct ensembl:ENSDARG00000068367 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4794
tp53 GeneProduct ensembl:ENSDARG00000035559 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7157
map2k4a GeneProduct ensembl:ENSDARG00000063583 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6416
cdkn2a/b GeneProduct ensembl:ENSDARG00000037262 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1029
casp8l1 GeneProduct ensembl:ENSDARG00000058341 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:841
xiap GeneProduct ensembl:ENSDARG00000016143 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:331
faslg GeneProduct ensembl:ENSDARG00000098913 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:356
tnfsf10 GeneProduct ensembl:ENSDARG00000057241 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8743
hells GeneProduct ensembl:ENSDARG00000057738 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3070
fadd GeneProduct ensembl:ENSDARG00000103021 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8772
mcl1a GeneProduct ensembl:ENSDARG00000009779 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4170
casp6 GeneProduct ensembl:ENSDARG00000093405 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:839
map3k1 GeneProduct ensembl:ENSDARG00000098405 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4214
tp63 GeneProduct ensembl:ENSDARG00000044356 Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8626

References

  1. Regulation of p53 in response to DNA damage. Lakin ND, Jackson SP. Oncogene. 1999 Dec 13;18(53):7644–55. PubMed Europe PMC Scholia
  2. mir-29 regulates Mcl-1 protein expression and apoptosis. Mott JL, Kobayashi S, Bronk SF, Gores GJ. Oncogene. 2007 Sep 13;26(42):6133–40. PubMed Europe PMC Scholia
  3. The p53-MDM2 network: from oscillations to apoptosis. Bose I, Ghosh B. J Biosci. 2007 Aug;32(5):991–7. PubMed Europe PMC Scholia
  4. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Park SY, Lee JH, Ha M, Nam JW, Kim VN. Nat Struct Mol Biol. 2009 Jan;16(1):23–9. PubMed Europe PMC Scholia