EPO receptor signaling (WP1336)

Danio rerio

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. ''Source: [[wikipedia:Erythropoietin_receptor|Wikipedia]]'' This pathway is based on ScienceSlides.

Authors

Thomas Kelder , Christine Chichester , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Danio rerio

Communities

Annotations

Pathway Ontology

erythropoietin signaling pathway

Participants

Label Type Compact URI Comment
epor GeneProduct ncbigene:751109
jak2b GeneProduct ncbigene:30298
src GeneProduct ncbigene:325084
stat1a GeneProduct ncbigene:30768
LOC563639 GeneProduct ncbigene:563639
grb2 GeneProduct ncbigene:406308
map2k1 GeneProduct ncbigene:406728
mapk3 GeneProduct ncbigene:399480
mapk1 GeneProduct ncbigene:360144
zgc:172250 GeneProduct ncbigene:100002225
LOC555840 GeneProduct ncbigene:555840
LOC792354 GeneProduct ncbigene:792354
zgc:77033 GeneProduct ncbigene:406598
EPO GeneProduct ncbigene:100004455
socs1 GeneProduct ncbigene:445073
cish GeneProduct ncbigene:767678
stat3 GeneProduct ncbigene:30767
ptpru GeneProduct ncbigene:335096
raf1 GeneProduct ncbigene:30716
LOC559281 GeneProduct ncbigene:559281
rasa1 GeneProduct ncbigene:100002155

References

  1. The molecular physiology of erythropoietin and the erythropoietin receptor. Zhu Y, D’Andrea AD. Curr Opin Hematol. 1994 Mar;1(2):113–8. PubMed Europe PMC Scholia
  2. The molecular biology of erythropoietin. Lacombe C, Mayeux P. Nephrol Dial Transplant. 1999;14 Suppl 2:22–8. PubMed Europe PMC Scholia