EPO receptor signaling (WP1336)

Danio rerio

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The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. ''Source: [[wikipedia:Erythropoietin_receptor|Wikipedia]]'' This pathway is based on ScienceSlides.

Authors

Thomas Kelder , Christine Chichester , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Danio rerio

Communities

Annotations

Pathway Ontology

erythropoietin signaling pathway

Participants

Label Type Compact URI Comment
epor GeneProduct ncbigene:751109
jak2b GeneProduct ncbigene:30298
src GeneProduct ncbigene:325084
epor GeneProduct ncbigene:751109
stat1a GeneProduct ncbigene:30768
LOC563639 GeneProduct ncbigene:563639
grb2 GeneProduct ncbigene:406308
map2k1 GeneProduct ncbigene:406728
mapk3 GeneProduct ncbigene:399480
mapk1 GeneProduct ncbigene:360144
zgc:172250 GeneProduct ncbigene:100002225
LOC555840 GeneProduct ncbigene:555840
LOC792354 GeneProduct ncbigene:792354
zgc:77033 GeneProduct ncbigene:406598
EPO GeneProduct ncbigene:100004455
EPO GeneProduct ncbigene:100004455
socs1 GeneProduct ncbigene:445073
cish GeneProduct ncbigene:767678
stat3 GeneProduct ncbigene:30767
stat3 GeneProduct ncbigene:30767
stat1a GeneProduct ncbigene:30768
ptpru GeneProduct ncbigene:335096
grb2 GeneProduct ncbigene:406308
raf1 GeneProduct ncbigene:30716
jak2b GeneProduct ncbigene:30298
LOC559281 GeneProduct ncbigene:559281
rasa1 GeneProduct ncbigene:100002155
raf1 GeneProduct ncbigene:30716
rasa1 GeneProduct ncbigene:100002155

References

  1. The molecular physiology of erythropoietin and the erythropoietin receptor. Zhu Y, D’Andrea AD. Curr Opin Hematol. 1994 Mar;1(2):113–8. PubMed Europe PMC Scholia
  2. The molecular biology of erythropoietin. Lacombe C, Mayeux P. Nephrol Dial Transplant. 1999;14 Suppl 2:22–8. PubMed Europe PMC Scholia