Insulin signaling (WP1313)
Danio rerio
Insulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose from the blood. Other branches of the signal cascade lead to cell growth and differentation.
Authors
Kristina Hanspers , Martina Summer-Kutmon , and Eric WeitzActivity
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Cited In
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Organisms
Danio rerioCommunities
Annotations
Pathway Ontology
insulin signaling pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
stxbp2 | GeneProduct | ensembl:ENSDARG00000007603 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6813 |
pik3cd | GeneProduct | ensembl:ENSDARG00000003250 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5293 |
pik3c3 | GeneProduct | ensembl:ENSDARG00000054829 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5289 |
cyth3a | GeneProduct | ensembl:ENSDARG00000007807 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9265 |
ptprfa | GeneProduct | ensembl:ENSDARG00000103479 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5792 |
rac1b | GeneProduct | ensembl:ENSDARG00000087954 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5879 |
gsk3b | GeneProduct | ensembl:ENSDARG00000017803 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2932 |
mink1 | GeneProduct | ensembl:ENSDARG00000035360 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:50488 |
grb2a | GeneProduct | ensembl:ENSDARG00000105276 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2885 |
SHC3 | GeneProduct | ensembl:ENSDARG00000098909 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:53358 |
irs1 | GeneProduct | ensembl:ENSDARG00000054087 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3667 |
slc2a1b | GeneProduct | ensembl:ENSDARG00000007412 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6513 |
rps6ka4 | GeneProduct | ensembl:ENSDARG00000044436 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8986 |
ikbkb | GeneProduct | ensembl:ENSDARG00000079123 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3551 |
socs3a | GeneProduct | ensembl:ENSDARG00000104400 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9021 |
prkchb | GeneProduct | ensembl:ENSDARG00000043243 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5583 |
kif5bb | GeneProduct | ensembl:ENSDARG00000103394 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3799 |
ehd2a | GeneProduct | ensembl:ENSDARG00000035137 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:30846 |
arf6b | GeneProduct | ensembl:ENSDARG00000052928 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:382 |
gyg1a | GeneProduct | ensembl:ENSDARG00000011934 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2992 |
akt2 | GeneProduct | ensembl:ENSDARG00000011219 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:208 |
srfa | GeneProduct | ensembl:ENSDARG00000053918 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6722 |
map3k2 | GeneProduct | ensembl:ENSDARG00000062884 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:10746 |
rab4a | GeneProduct | ensembl:ENSDARG00000019144 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5867 |
prkcdb | GeneProduct | ensembl:ENSDARG00000070651 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5580 |
akt1 | GeneProduct | ensembl:ENSDARG00000099657 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:207 |
cap1 | GeneProduct | ensembl:ENSDARG00000016350 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:10487 |
rheb | GeneProduct | ensembl:ENSDARG00000090213 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6009 |
pfkma | GeneProduct | ensembl:ENSDARG00000014179 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5213 |
stxbp1a | GeneProduct | ensembl:ENSDARG00000001994 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6812 |
mapk12b | GeneProduct | ensembl:ENSDARG00000006409 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6300 |
pik3r1 | GeneProduct | ensembl:ENSDARG00000038524 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5295 |
map3k5 | GeneProduct | ensembl:ENSDARG00000005416 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4217 |
irs2a | GeneProduct | ensembl:ENSDARG00000037099 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8660 |
pik3c2g | GeneProduct | ensembl:ENSDARG00000099803 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5288 |
pik3r2 | GeneProduct | ensembl:ENSDARG00000018060 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5296 |
mapk10 | GeneProduct | ensembl:ENSDARG00000102730 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5602 |
map3k3 | GeneProduct | ensembl:ENSDARG00000060348 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4215 |
mapk3 | GeneProduct | ensembl:ENSDARG00000070573 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5595 |
ptenb | GeneProduct | ensembl:ENSDARG00000056623 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5728 |
elk1 | GeneProduct | ensembl:ENSDARG00000078066 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2002 |
shc1 | GeneProduct | ensembl:ENSDARG00000075437 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6464 |
crk | GeneProduct | ensembl:ENSDARG00000055635 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1398 |
trib3 | GeneProduct | ensembl:ENSDARG00000016200 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:57761 |
stxbp4 | GeneProduct | ensembl:ENSDARG00000076997 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:252983 |
rps6kal | GeneProduct | ensembl:ENSDARG00000037574 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:27330 |
insrb | GeneProduct | ensembl:ENSDARG00000071524 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3643 |
xbp1 | GeneProduct | ensembl:ENSDARG00000035622 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7494 |
foxo1b | GeneProduct | ensembl:ENSDARG00000061549 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2308 |
tbc1d4 | GeneProduct | ensembl:ENSDARG00000075156 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9882 |
prkcbb | GeneProduct | ensembl:ENSDARG00000022254 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5579 |
map2k7 | GeneProduct | ensembl:ENSDARG00000008279 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5609 |
sos1 | GeneProduct | ensembl:ENSDARG00000100503 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6654 |
rac2 | GeneProduct | ensembl:ENSDARG00000038010 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5880 |
fosab | GeneProduct | ensembl:ENSDARG00000031683 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2353 |
pik3cg | GeneProduct | ensembl:ENSDARG00000017757 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5294 |
rrad | GeneProduct | ensembl:ENSDARG00000052011 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6236 |
pik3ca | GeneProduct | ensembl:ENSDARG00000075456 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = En:ENSG00000121879 |
sgk3 | GeneProduct | ensembl:ENSDARG00000062460 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:23678 |
SH2B2 | GeneProduct | ensembl:ENSDARG00000090421 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:10603 |
mapk13 | GeneProduct | ensembl:ENSDARG00000058470 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5603 |
gys1 | GeneProduct | ensembl:ENSDARG00000016875 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2997 |
TSC2 | GeneProduct | ensembl:ENSDARG00000103125 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7249 |
pik3cb | GeneProduct | ensembl:ENSDARG00000075253 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5291 |
map3k1 | GeneProduct | ensembl:ENSDARG00000098405 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4214 |
map4k3b | GeneProduct | ensembl:ENSDARG00000071357 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8491 |
enpp1 | GeneProduct | ensembl:ENSDARG00000005789 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5167 |
map2k6 | GeneProduct | ensembl:ENSDARG00000099184 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5608 |
arhgap33 | GeneProduct | ensembl:ENSDARG00000011333 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:115703 |
map3k8 | GeneProduct | ensembl:ENSDARG00000061710 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1326 |
pfklb | GeneProduct | ensembl:ENSDARG00000099755 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5211 |
tsc1a | GeneProduct | ensembl:ENSDARG00000026048 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7248 |
map3k12 | GeneProduct | ensembl:ENSDARG00000103651 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:7786 |
rps6ka5 | GeneProduct | ensembl:ENSDARG00000060551 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9252 |
stx4 | GeneProduct | ensembl:ENSDARG00000052518 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6810 |
igf1ra | GeneProduct | ensembl:ENSDARG00000027423 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3480 |
prkcz | GeneProduct | ensembl:ENSDARG00000043332 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5590 |
snap25b | GeneProduct | ensembl:ENSDARG00000058117 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6616 |
map2k4a | GeneProduct | ensembl:ENSDARG00000063583 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6416 |
GRB14 | GeneProduct | ensembl:ENSDARG00000068280 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2888 |
prkcq | GeneProduct | ensembl:ENSDARG00000034173 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5588 |
rps6ka1 | GeneProduct | ensembl:ENSDARG00000033437 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6195 |
mapk7 | GeneProduct | ensembl:ENSDARG00000023110 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5598 |
rps6ka2 | GeneProduct | ensembl:ENSDARG00000028469 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6196 |
mapk14a | GeneProduct | ensembl:ENSDARG00000000857 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1432 |
rps6kb1a | GeneProduct | ensembl:ENSDARG00000018399 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6198 |
rhoq | GeneProduct | ensembl:ENSDARG00000025953 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:23433 |
MAP3K11 | GeneProduct | ensembl:ENSDARG00000091521 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4296 |
prkaa2 | GeneProduct | ensembl:ENSDARG00000060641 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5563 |
snap23.1 | GeneProduct | ensembl:ENSDARG00000012874 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8773 |
ptpn1 | GeneProduct | ensembl:ENSDARG00000007923 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5770 |
mapk8a | GeneProduct | ensembl:ENSDARG00000031888 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5599 |
inppl1a | GeneProduct | ensembl:ENSDARG00000104222 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3636 |
cblb | GeneProduct | ensembl:ENSDARG00000015199 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:868 |
map3k7 | GeneProduct | ensembl:ENSDARG00000020469 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6885 |
stxbp3 | GeneProduct | ensembl:ENSDARG00000008142 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6814 |
inpp4ab | GeneProduct | ensembl:ENSDARG00000070995 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3631 |
sgk1 | GeneProduct | ensembl:ENSDARG00000025522 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6446 |
cbl | GeneProduct | ensembl:ENSDARG00000009958 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:867 |
pik3r4 | GeneProduct | ensembl:ENSDARG00000060469 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:30849 |
mapk11 | GeneProduct | ensembl:ENSDARG00000045836 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5600 |
mapk9 | GeneProduct | ensembl:ENSDARG00000077364 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5601 |
ptpn11a | GeneProduct | ensembl:ENSDARG00000020334 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5781 |
gys2 | GeneProduct | ensembl:ENSDARG00000004904 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2998 |
jun | GeneProduct | ensembl:ENSDARG00000043531 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3725 |
socs1a | GeneProduct | ensembl:ENSDARG00000038095 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:8651 |
mapk6 | GeneProduct | ensembl:ENSDARG00000032103 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5597 |
eif4ea | GeneProduct | ensembl:ENSDARG00000077012 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1977 |
shc2 | GeneProduct | ensembl:ENSDARG00000062080 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:25759 |
flot2b | GeneProduct | ensembl:ENSDARG00000069774 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2319 |
cblc | GeneProduct | ensembl:ENSDARG00000078217 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:23624 |
myo1cb | GeneProduct | ensembl:ENSDARG00000061579 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4641 |
gab1 | GeneProduct | ensembl:ENSDARG00000037018 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2549 |
rhoj | GeneProduct | ensembl:ENSDARG00000020250 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:57381 |
gsk3ab | GeneProduct | ensembl:ENSDARG00000015681 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2931 |
prkci | GeneProduct | ensembl:ENSDARG00000021225 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5584 |
prkaa1 | GeneProduct | ensembl:ENSDARG00000060596 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5562 |
sorbs1 | GeneProduct | ensembl:ENSDARG00000103435 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:10580 |
sos2 | GeneProduct | ensembl:ENSDARG00000060506 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6655 |
MAP3K13 | GeneProduct | ensembl:ENSDARG00000009493 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9175 |
ppp1r3ab | GeneProduct | ensembl:ENSDARG00000088813 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5506 |
raf1a | GeneProduct | ensembl:ENSDARG00000096415 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5894 |
mtor | GeneProduct | ensembl:ENSDARG00000053196 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2475 |
PRKCA | GeneProduct | ensembl:ENSDARG00000099841 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5578 |
lipeb | GeneProduct | ensembl:ENSDARG00000101145 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3991 |
mapk4 | GeneProduct | ensembl:ENSDARG00000017681 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5596 |
map4k6 | GeneProduct | ensembl:ENSDARG00000033444 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5871 |
pdpk1a | GeneProduct | ensembl:ENSDARG00000062304 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5170 |
hrasa | GeneProduct | ensembl:ENSDARG00000098497 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:3265 |
rapgef1a | GeneProduct | ensembl:ENSDARG00000043593 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2889 |
foxo3b | GeneProduct | ensembl:ENSDARG00000042904 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2309 |
map2k5 | GeneProduct | ensembl:ENSDARG00000011851 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5607 |
grb10a | GeneProduct | ensembl:ENSDARG00000002013 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:2887 |
egr1 | GeneProduct | ensembl:ENSDARG00000037421 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:1958 |
map3k10 | GeneProduct | ensembl:ENSDARG00000055672 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4294 |
vamp2 | GeneProduct | ensembl:ENSDARG00000056877 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:6844 |
pik3c2a | GeneProduct | ensembl:ENSDARG00000060841 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5286 |
mapk1 | GeneProduct | ensembl:ENSDARG00000027552 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5594 |
flot1b | GeneProduct | ensembl:ENSDARG00000037998 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:10211 |
pik3ca | GeneProduct | ensembl:ENSDARG00000075456 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5290 |
map2k1 | GeneProduct | ensembl:ENSDARG00000007825 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5604 |
MAP3K6 | GeneProduct | ensembl:ENSDARG00000104760 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9064 |
sgk2a | GeneProduct | ensembl:ENSDARG00000063370 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:10110 |
map3k4 | GeneProduct | ensembl:ENSDARG00000104835 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4216 |
map3k9 | GeneProduct | ensembl:ENSDARG00000013491 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:4293 |
kif3a | GeneProduct | ensembl:ENSDARG00000087538 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:11127 |
map4k5 | GeneProduct | ensembl:ENSDARG00000039125 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:11183 |
map2k2a | GeneProduct | ensembl:ENSDARG00000006609 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:5605 |
map3k14a | GeneProduct | ensembl:ENSDARG00000074060 | Homology Mapping from Homo sapiens to Danio rerio: Original ID = L:9020 |
References
- A mathematical model and computer simulation study of insulin sensitive glucose transporter regulation. Quon MJ, Campfield LA. J Theor Biol. 1991 May 7;150(1):93–107. PubMed Europe PMC Scholia
- Insulin signalling. Bevan P. J Cell Sci. 2001 Apr;114(Pt 8):1429–30. PubMed Europe PMC Scholia
- Insulin signalling and the regulation of glucose and lipid metabolism. Saltiel AR, Kahn CR. Nature. 2001 Dec 13;414(6865):799–806. PubMed Europe PMC Scholia