Selenium metabolism selenoproteins (WP1293)

Rattus norvegicus

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* Comments belonging to specific genes on the Selenoprotein pathway ** TRXND3 gene: Although the geneID is correct, the sequence of this gene was guessed by analogy. ** Cystathionine gamma-lyase is the mammalian form of bacterial methionine gamma-lyase ** A selenoprotein database exists at: http://www.selenodb.org.

Authors

Daniela Digles and Eric Weitz

Activity

last edited

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

selenoamino acid metabolic pathway

Participants

Label Type Compact URI Comment
SeC Metabolite hmdb:HMDB0003288
SeMet Metabolite hmdb:HMDB0003966
Selenophosphate Metabolite hmdb:HMDB0006407
SelM GeneProduct ncbigene:498398
Nfkb1 GeneProduct ncbigene:81736
TXNRD3 GeneProduct ncbigene:297437
Selenbp1 GeneProduct ncbigene:140927
SEPN1 GeneProduct ncbigene:362624
Txnrd1 GeneProduct ncbigene:58819
Seli GeneProduct ncbigene:362713
Secp43 GeneProduct ncbigene:65241
Nfe2l2 GeneProduct ncbigene:83619
Sep15 GeneProduct ncbigene:113922
Gpx2 GeneProduct ncbigene:29326
Gpx4 GeneProduct ncbigene:29328
Gpx1 GeneProduct ncbigene:24404
Sepx1 GeneProduct ncbigene:685059
Jun GeneProduct ensembl:ENSRNOG00000026293
Sars2 GeneProduct ncbigene:292759
Sephs2 GeneProduct ncbigene:308993
Sels GeneProduct ncbigene:286900
SelT GeneProduct ncbigene:365802
Scly GeneProduct ncbigene:363285
Dio3 GeneProduct ncbigene:29475
Sepp1 GeneProduct ncbigene:29360
Rela GeneProduct ncbigene:309165
Sepw1 GeneProduct ncbigene:25545
Selk GeneProduct ncbigene:290549
Txnrd2 GeneProduct ncbigene:50551
Fos GeneProduct ensembl:ENSRNOG00000008015
Dio1 GeneProduct ncbigene:25430
Gpx3 GeneProduct ncbigene:64317
Crem GeneProduct ncbigene:25620
Gpx6 GeneProduct ncbigene:259233
Sephs1 GeneProduct ncbigene:291314
Sars GeneProduct ncbigene:266975
Eefsec GeneProduct ncbigene:500255
SelV GeneProduct ncbigene:499113
Selo GeneProduct ncbigene:315216
Sp1 GeneProduct ncbigene:24790
Rpl30 GeneProduct ncbigene:64640
Sp3 GeneProduct ncbigene:367846
Sla GeneProduct ncbigene:338477
Dio2 GeneProduct ncbigene:65162
Fabp1 GeneProduct ncbigene:24360

References

  1. Temporal changes in tissue glutathione in response to chemical form, dose, and duration of selenium treatment. Relevance to cancer chemoprevention by selenium. Thompson HJ, Clement IP. Biol Trace Elem Res. 1991 Aug;30(2):163–73. PubMed Europe PMC Scholia
  2. Tissue selenium levels in selenium-supplemented rats and their relevance in mammary cancer protection. Ip C, Hayes C. Carcinogenesis. 1989 May;10(5):921–5. PubMed Europe PMC Scholia
  3. Vitamin B6 enzymes participating in selenium amino acid metabolism. Soda K, Oikawa T, Esaki N. Biofactors. 1999;10(2–3):257–62. PubMed Europe PMC Scholia
  4. Bioactivation of selenocysteine Se-conjugates by a highly purified rat renal cysteine conjugate beta-lyase/glutamine transaminase K. Commandeur JN, Andreadou I, Rooseboom M, Out M, de Leur LJ, Groot E, et al. J Pharmacol Exp Ther. 2000 Aug;294(2):753–61. PubMed Europe PMC Scholia
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  6. Human selenoproteins at a glance. Gromer S, Eubel JK, Lee BL, Jacob J. Cell Mol Life Sci. 2005 Nov;62(21):2414–37. PubMed Europe PMC Scholia
  7. Unique features of selenocysteine incorporation function within the context of general eukaryotic translational processes. Small-Howard AL, Berry MJ. Biochem Soc Trans. 2005 Dec;33(Pt 6):1493–7. PubMed Europe PMC Scholia
  8. Biosynthesis of selenocysteine on its tRNA in eukaryotes. Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, et al. PLoS Biol. 2007 Jan;5(1):e4. PubMed Europe PMC Scholia
  9. Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice. Wang H, Zhang J, Yu H. Free Radic Biol Med. 2007 May 15;42(10):1524–33. PubMed Europe PMC Scholia
  10. From selenium to selenoproteins: synthesis, identity, and their role in human health. Papp LV, Lu J, Holmgren A, Khanna KK. Antioxid Redox Signal. 2007 Jul;9(7):775–806. PubMed Europe PMC Scholia
  11. The role of selenium in chronic disease. Boosalis MG. Nutr Clin Pract. 2008;23(2):152–60. PubMed Europe PMC Scholia