Type II interferon signaling (IFNG) (WP1289)

Rattus norvegicus

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]

Authors

Daniela Digles and Martina Summer-Kutmon

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

type II interferon signaling pathway

Participants

Label Type Compact URI Comment
Ifng GeneProduct ncbigene:25712
Ifngr1 GeneProduct ncbigene:116465
Ifngr2 GeneProduct ncbigene:360697
Jak1 GeneProduct ncbigene:84598
Jak2 GeneProduct ncbigene:24514
Socs3 GeneProduct ncbigene:89829
Socs1 GeneProduct ncbigene:252971
Ptpn11 GeneProduct ncbigene:25622
Stat1 GeneProduct ncbigene:25124
Stat2 GeneProduct ncbigene:288774
Irf9 GeneProduct ncbigene:305896
Prkcd GeneProduct ncbigene:170538
Reg1a GeneProduct ncbigene:24714
Irf4 GeneProduct ncbigene:291100
Sfpi1 GeneProduct ncbigene:366126
Ifnb1 GeneProduct ncbigene:24481
Nos2 GeneProduct ncbigene:24599
Gbp1 GeneProduct ncbigene:304266
HIST2H4 GeneProduct ncbigene:295277
Psmb9 GeneProduct ncbigene:24967
Tap1 GeneProduct ncbigene:24811
Oas1a GeneProduct ncbigene:192281
Cxcl10 GeneProduct ncbigene:245920
Ciita GeneProduct ncbigene:85483
Cybb GeneProduct ncbigene:66021
Il1b GeneProduct ncbigene:24494
Ifit2 GeneProduct ncbigene:294091
Eif2ak2 GeneProduct ncbigene:54287
Irf1 GeneProduct ncbigene:24508
Icam1 GeneProduct ncbigene:25464
Cxcl9 GeneProduct ncbigene:246759
G1p2 GeneProduct ncbigene:298693
Irf8 GeneProduct ncbigene:292060
Irf2 GeneProduct ncbigene:290749

References

  1. A logic-based diagram of signalling pathways central to macrophage activation. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, et al. BMC Syst Biol. 2008 Apr 23;2:36. PubMed Europe PMC Scholia