Type II interferon signaling (IFNG) (WP1289)

Rattus norvegicus

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Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]

Authors

Daniela Digles and Martina Summer-Kutmon

Activity

last edited

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Cited In

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

type II interferon signaling pathway

Participants

Label Type Compact URI Comment
Ifng GeneProduct ncbigene:25712
Ifng GeneProduct ncbigene:25712
Ifng GeneProduct ncbigene:25712
Ifngr1 GeneProduct ncbigene:116465
Ifngr2 GeneProduct ncbigene:360697
Jak1 GeneProduct ncbigene:84598
Jak2 GeneProduct ncbigene:24514
Jak2 GeneProduct ncbigene:24514
Ifngr2 GeneProduct ncbigene:360697
Ifngr1 GeneProduct ncbigene:116465
Jak1 GeneProduct ncbigene:84598
Ifng GeneProduct ncbigene:25712
Jak2 GeneProduct ncbigene:24514
Ifngr2 GeneProduct ncbigene:360697
Ifngr1 GeneProduct ncbigene:116465
Jak1 GeneProduct ncbigene:84598
Ifngr2 GeneProduct ncbigene:360697
Ifng GeneProduct ncbigene:25712
Jak1 GeneProduct ncbigene:84598
Jak2 GeneProduct ncbigene:24514
Ifngr1 GeneProduct ncbigene:116465
Socs3 GeneProduct ncbigene:89829
Socs1 GeneProduct ncbigene:252971
Ptpn11 GeneProduct ncbigene:25622
Stat1 GeneProduct ncbigene:25124
Stat1 GeneProduct ncbigene:25124
Stat2 GeneProduct ncbigene:288774
Stat2 GeneProduct ncbigene:288774
Stat1 GeneProduct ncbigene:25124
Stat2 GeneProduct ncbigene:288774
Stat1 GeneProduct ncbigene:25124
Irf9 GeneProduct ncbigene:305896
Irf9 GeneProduct ncbigene:305896
Irf9 GeneProduct ncbigene:305896
Stat1 GeneProduct ncbigene:25124
Stat1 GeneProduct ncbigene:25124
Irf9 GeneProduct ncbigene:305896
Stat1 GeneProduct ncbigene:25124
Stat1 GeneProduct ncbigene:25124
Stat1 GeneProduct ncbigene:25124
Stat1 GeneProduct ncbigene:25124
Prkcd GeneProduct ncbigene:170538
Reg1a GeneProduct ncbigene:24714
Irf4 GeneProduct ncbigene:291100
Sfpi1 GeneProduct ncbigene:366126
Stat1 GeneProduct ncbigene:25124
Stat1 GeneProduct ncbigene:25124
Stat1 GeneProduct ncbigene:25124
Stat1 GeneProduct ncbigene:25124
Stat2 GeneProduct ncbigene:288774
Stat1 GeneProduct ncbigene:25124
Irf9 GeneProduct ncbigene:305896
Irf9 GeneProduct ncbigene:305896
Stat1 GeneProduct ncbigene:25124
Stat1 GeneProduct ncbigene:25124
Irf9 GeneProduct ncbigene:305896
Ifnb1 GeneProduct ncbigene:24481
Nos2 GeneProduct ncbigene:24599
Gbp1 GeneProduct ncbigene:304266
HIST2H4 GeneProduct ncbigene:295277
Psmb9 GeneProduct ncbigene:24967
Tap1 GeneProduct ncbigene:24811
Oas1a GeneProduct ncbigene:192281
Cxcl10 GeneProduct ncbigene:245920
Ciita GeneProduct ncbigene:85483
Cybb GeneProduct ncbigene:66021
Il1b GeneProduct ncbigene:24494
Ifit2 GeneProduct ncbigene:294091
Eif2ak2 GeneProduct ncbigene:54287
Irf1 GeneProduct ncbigene:24508
Icam1 GeneProduct ncbigene:25464
Cxcl9 GeneProduct ncbigene:246759
G1p2 GeneProduct ncbigene:298693
Irf8 GeneProduct ncbigene:292060
Irf8 GeneProduct ncbigene:292060
Irf2 GeneProduct ncbigene:290749

References

  1. A logic-based diagram of signalling pathways central to macrophage activation. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, et al. BMC Syst Biol. 2008 Apr 23;2:36. PubMed Europe PMC Scholia