Type II interferon signaling (IFNG) (WP1289)
Rattus norvegicus
Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]
Authors
Daniela Digles and Martina Summer-KutmonActivity
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Organisms
Rattus norvegicusCommunities
Annotations
Pathway Ontology
type II interferon signaling pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
Ifng | GeneProduct | ncbigene:25712 | |
Ifngr1 | GeneProduct | ncbigene:116465 | |
Ifngr2 | GeneProduct | ncbigene:360697 | |
Jak1 | GeneProduct | ncbigene:84598 | |
Jak2 | GeneProduct | ncbigene:24514 |
References
- A logic-based diagram of signalling pathways central to macrophage activation. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, et al. BMC Syst Biol. 2008 Apr 23;2:36. PubMed Europe PMC Scholia