Non-homologous end joining (WP1277)

Rattus norvegicus

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(From http://en.wikipedia.org/wiki/Non-homologous_end_joining) Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.

Authors

Martijn Van Iersel and Daniela Digles

Activity

last edited

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

non-homologous end joining pathway of double-strand break repair

Participants

Label Type Compact URI Comment
NP_001101797.1 GeneProduct ensembl:ENSRNOG00000025028
Xrcc5 GeneProduct ensembl:ENSRNOG00000016105
Xrcc6 GeneProduct ensembl:ENSRNOG00000006392
Xrcc4 GeneProduct ensembl:ENSRNOG00000029966
Nhej1 GeneProduct ncbigene:363251
Rad50 GeneProduct ensembl:ENSRNOG00000033065
Mre11a GeneProduct ensembl:ENSRNOG00000009506
LOC363251 GeneProduct ensembl:ENSRNOG00000018162

References