EPO receptor signaling (WP1249)
Mus musculus
The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. ''Source: [[wikipedia:Erythropoietin_receptor|Wikipedia]]'' This pathway is based on ScienceSlides.
Authors
Thomas Kelder , Christine Chichester , and Eric WeitzActivity
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Cited In
- Hematopoietic stem-cell senescence and myocardial repair - Coronary artery disease genotype/phenotype analysis of post-MI myocardial regeneration response induced by CABG/CD133+ bone marrow hematopoietic stem cell treatment in RCT PERFECT Phase 3 (2020).
- Proteomic profiling of salivary gland after nonviral gene transfer mediated by conventional plasmids and minicircles (2014).
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Organisms
Mus musculusCommunities
Annotations
Pathway Ontology
erythropoietin signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Epor | GeneProduct | ncbigene:13857 | |
| Jak2 | GeneProduct | ncbigene:16452 | |
| Src | GeneProduct | ncbigene:20779 | |
| Stat1 | GeneProduct | ncbigene:20846 | |
| Shc1 | GeneProduct | ncbigene:20416 | |
| Grb2 | GeneProduct | ncbigene:14784 | |
| Map2k1 | GeneProduct | ncbigene:26395 | |
| Mapk3 | GeneProduct | ncbigene:26417 | |
| Mapk1 | GeneProduct | ncbigene:26413 | |
| Map2k2 | GeneProduct | ncbigene:26396 | |
| Pdk1 | GeneProduct | ncbigene:228026 | |
| Akt1 | GeneProduct | ncbigene:11651 | |
| Pik3cg | GeneProduct | ncbigene:30955 | |
| Epo | GeneProduct | ncbigene:13856 | |
| Socs1 | GeneProduct | ncbigene:12703 | |
| Stat5b | GeneProduct | ncbigene:20851 | |
| Cish | GeneProduct | ncbigene:12700 | |
| Stat5a | GeneProduct | ncbigene:20850 | |
| Stat3 | GeneProduct | ncbigene:20848 | |
| Ptprc | GeneProduct | ncbigene:19264 | |
| Ptpru | GeneProduct | ncbigene:19273 | |
| Raf1 | GeneProduct | ncbigene:110157 | |
| Sos1 | GeneProduct | ncbigene:20662 | |
| Irs2 | GeneProduct | ncbigene:384783 | |
| Irs1 | GeneProduct | ncbigene:16367 | |
| Rasa1 | GeneProduct | ncbigene:218397 |
References
- The molecular physiology of erythropoietin and the erythropoietin receptor. Zhu Y, D’Andrea AD. Curr Opin Hematol. 1994 Mar;1(2):113–8. PubMed Europe PMC Scholia
- The molecular biology of erythropoietin. Lacombe C, Mayeux P. Nephrol Dial Transplant. 1999;14 Suppl 2:22–8. PubMed Europe PMC Scholia