Estrogen signaling (WP1244)

Mus musculus

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Estrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.

Authors

Kristina Hanspers , Christine Chichester , and Finterly Hu

Activity

last edited

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

estrogen signaling pathway

Participants

Label Type Compact URI Comment
Estradiol Metabolite hmdb:HMDB0000151
Cyclic AMP Metabolite hmdb:HMDB0000058
Hdac2 GeneProduct ncbigene:15182 HDAC2; histone deacetylase 2
Mapk9 GeneProduct ncbigene:26420
Ercc2 GeneProduct ncbigene:13871
Taf7 GeneProduct ncbigene:24074
Taf13 GeneProduct ncbigene:99730
Sin3a GeneProduct ncbigene:20466
Mapk1 GeneProduct ensembl:ENSMUSG00000063358
Mnat1 GeneProduct ncbigene:17420
Ccnd1 GeneProduct ncbigene:12443
Gtf2b GeneProduct ncbigene:229906
Bcl2 GeneProduct ncbigene:12043
Polr2i GeneProduct ncbigene:69920
Hdac3 GeneProduct ncbigene:15183 HDAC3; histone deacetylase 3
Ercc3 GeneProduct ncbigene:13872
Esr1 GeneProduct ncbigene:13982
Creb1 GeneProduct ncbigene:12912
Pik3ca GeneProduct ncbigene:18706
Ep300 GeneProduct ncbigene:328572
Ikbkb GeneProduct ensembl:ENSMUSG00000031537
Ncor1 GeneProduct ncbigene:20185
Polr2h GeneProduct ncbigene:245841
Polr2b GeneProduct ncbigene:231329
Prkaca GeneProduct ncbigene:18747
Polr2c GeneProduct ncbigene:20021
Taf12 GeneProduct ncbigene:66464
Cdk7 GeneProduct ncbigene:12572
Jun GeneProduct ncbigene:16476
Gnas GeneProduct ncbigene:14683
Hdac7 GeneProduct ncbigene:56233 HDAC7A; histone deacetylase 7
Brca1 GeneProduct ncbigene:12189
Akt1 GeneProduct ncbigene:11651
Gtf2e1 GeneProduct ncbigene:74197
Hdac6 GeneProduct ncbigene:15185 HDAC6; histone deacetylase 6
Taf9 GeneProduct ncbigene:108143
Polr2e GeneProduct ncbigene:66420
Gtf2h4 GeneProduct ncbigene:14885
Gtf2h1 GeneProduct ncbigene:14884
Gnb1 GeneProduct ncbigene:14688
Gtf2a2 GeneProduct ncbigene:235459
Gtf2e2 GeneProduct ncbigene:68153
Src GeneProduct ncbigene:20779
Hras1 GeneProduct ensembl:ENSMUSG00000025499
Gtf2f2 GeneProduct ncbigene:68705
Ikbkg GeneProduct ensembl:ENSMUSG00000004221
Polr2j GeneProduct ncbigene:20022
Sos1 GeneProduct ncbigene:20662
Braf GeneProduct ncbigene:109880
Map2k1 GeneProduct ensembl:ENSMUSG00000004936
Mapk14 GeneProduct ncbigene:26416
Nfkb1 GeneProduct ncbigene:18033
Elk1 GeneProduct ncbigene:13712
Shc2 GeneProduct ncbigene:216148
Hdac1 GeneProduct ncbigene:433759 HDAC1; histone deacetylase 1
Taf6 GeneProduct ncbigene:21343
Tbp GeneProduct ncbigene:21374
Polr2k GeneProduct ncbigene:17749
Crebbp GeneProduct ncbigene:12914
Gper GeneProduct ncbigene:76854
Fos GeneProduct ncbigene:14281
Polr2f GeneProduct ncbigene:69833
Grb2 GeneProduct ncbigene:14784
Ilk GeneProduct ncbigene:16202
Gtf2h2 GeneProduct ncbigene:23894
Taf5 GeneProduct ncbigene:226182
Gngt1 GeneProduct ncbigene:14699
Polr2g GeneProduct ncbigene:67710
Hdac5 GeneProduct ncbigene:15184 HDAC5; histone deacetylase 5
Hdac8 GeneProduct ncbigene:70315 HDAC8; histone deacetylase
Hdac4 GeneProduct ncbigene:208727 HDAC4; histone deacetylase 4
Gtf2h3 GeneProduct ncbigene:209357
Polr2a GeneProduct ncbigene:20020
Ccnh GeneProduct ncbigene:66671
Sp1 GeneProduct ncbigene:20683
Chuk GeneProduct ensembl:ENSMUSG00000025199

References