Non-homologous end joining (WP1242)

Mus musculus

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
(From http://en.wikipedia.org/wiki/Non-homologous_end_joining) Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells.

Authors

Martijn Van Iersel and Daniela Digles

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

non-homologous end joining pathway of double-strand break repair

Participants

Label Type Compact URI Comment
Prkdc GeneProduct ensembl:ENSMUSG00000022672
Xrcc5 GeneProduct ensembl:ENSMUSG00000026187
Xrcc6 GeneProduct ensembl:ENSMUSG00000022471
Xrcc4 GeneProduct ensembl:ENSMUSG00000021615
Nhej1 GeneProduct ncbigene:75570
Rad50 GeneProduct ensembl:ENSMUSG00000020380
Mre11a GeneProduct ensembl:ENSMUSG00000031928
Nhej1 GeneProduct ensembl:ENSMUSG00000026162

References