Non-homologous end joining (WP1242)

Mus musculus

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Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is referred to as “non-homologous” because the break ends are directly ligated without the need for a homologous template, in contrast to homologous recombination, which requires a homologous sequence to guide repair. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant double-strand break repair pathway in mammalian cells. Source Wikipedia.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Martijn Van Iersel , Daniela Digles , and Egon Willighagen

Activity

last edited

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

non-homologous end joining pathway of double-strand break repair

Participants

Label Type Compact URI Comment
Xrcc5 GeneProduct ensembl:ENSMUSG00000026187
Xrcc6 GeneProduct ensembl:ENSMUSG00000022471
Prkdc GeneProduct ensembl:ENSMUSG00000022672
Mre11a GeneProduct ensembl:ENSMUSG00000031928
Xrcc4 GeneProduct ensembl:ENSMUSG00000021615
Nhej1 GeneProduct ncbigene:75570
Rad50 GeneProduct ensembl:ENSMUSG00000020380
Nhej1 GeneProduct ensembl:ENSMUSG00000026162

References