Pentose phosphate pathway (WP1231)
Anopheles gambiae
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. This metabolic pathway is parallel to glycolysis. It generates NADPH and pentoses (5-carbon sugars) as well as ribose 5-phosphate, the last one a precursor for the synthesis of nucleotides. While it does involve oxidation of glucose, its primary role is anabolic rather than catabolic. The pathway is especially important in erythrocytes. There are two distinct phases in the pathway. The first is the oxidative phase, in which NADPH is generated, and the second is the non-oxidative synthesis of 5-carbon sugars.
Authors
Friederike Ehrhart , Dan Lawson , Lotte Sevenich , Martina Summer-Kutmon , and Eric WeitzActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Anopheles gambiaeCommunities
Annotations
Pathway Ontology
pentose phosphate pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Sedoheptulose-7-Phosphate | Metabolite | cas:2646-35-7 | |
| Fructose-6-Phosphate | Metabolite | cas:643-13-0 | |
| Xylulose-5-Phosphate | Metabolite | cas:60802-29-1 | |
| Glyceraldehyde-3-phosphate | Metabolite | hmdb:HMDB0001112 | |
| Ribose-5-Phosphate | Metabolite | cas:3615-55-2 | |
| 6-Phosphogluconate | Metabolite | hmdb:HMDB0001316 | |
| Erythrose-4-Phosphate | Metabolite | hmdb:HMDB0001321 | |
| Ribulose-5-Phosphate | Metabolite | cas:4151-19-3 | |
| Glucose-6-Phosphate | Metabolite | cas:59-56-3 | |
| 6-Phosphonoglucono-delta-lactone | Metabolite | hmdb:HMDB0001127 | |
| Fructose-6-Phosphate | Metabolite | hmdb:HMDB0000124 | |
| G6PD | GeneProduct | ensembl:AGAP012678 | |
| AgaP_AGAP010866 | GeneProduct | ncbigene:1271093 | |
| AgaP_AGAP005080 | GeneProduct | ncbigene:1274761 | |
| AgaP_AGAP011800 | GeneProduct | ncbigene:1280848 | |
| AgaP_AGAP011457 | GeneProduct | ncbigene:3291340 | |
| AgaP_AGAP004197 | GeneProduct | ncbigene:1274031 |