ACE inhibitor pathway (WP1151)

Canis familiaris

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists. Source: PharmGKB (http://www.pharmgkb.org/do/serve?objId=PA2023&objCls=Pathway)

Authors

Thomas Kelder , Egon Willighagen , Christine Chichester , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Canis familiaris

Communities

Annotations

Pathway Ontology

ACE inhibitor drug pathway

Participants

Label Type Compact URI Comment
Angiotensin I Metabolite pubchem.compound:3081372
ACE Inhibitor Metabolite chebi:35457
Aldosterone Metabolite kegg.compound:C01780
Bradykinin Metabolite hmdb:HMDB0004246
Angiotensin II Metabolite hmdb:HMDB0001035
AGT GeneProduct ncbigene:403783
ACE GeneProduct ncbigene:610668
KNG1 GeneProduct ncbigene:478666
AGTR1 GeneProduct ncbigene:403836
NOS3 GeneProduct ncbigene:403784
AGTR2 GeneProduct ncbigene:403835
REN GeneProduct ncbigene:403838
BDKRB2 GeneProduct ncbigene:403658

References

  1. The emerging role of ACE2 in physiology and disease. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus ADME, et al. J Pathol. 2007 May;212(1):1–11. PubMed Europe PMC Scholia