Hedgehog signaling pathway (WP1141)

Canis familiaris

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The Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, prevents inhibition of a 7 transmembrane receptor called Smoothened. This leads to activation of GLI family of transcription factors (GLI1-3). Signaling through the Hedgehog pathway is essential for development of many tissues and organs. This pathway is highly conserved among metazoans. Aberrant activation of this pathway has been associated with a number of human malignancies including carcinoma of lung, esophagus, pancreas and prostate. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_10

Authors

Alex Pico , Christine Chichester , and Eric Weitz

Activity

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Organisms

Canis familiaris

Communities

Annotations

Pathway Ontology

Hedgehog signaling pathway

Participants

Label Type Compact URI Comment
PTCH2 GeneProduct ncbigene:482519
SHH GeneProduct ncbigene:608860
CDC2 GeneProduct ncbigene:488997
SMO GeneProduct ncbigene:482262
IHH GeneProduct ncbigene:488533
GLI3 GeneProduct ncbigene:483244
SKI GeneProduct ncbigene:489610
SUFU GeneProduct ncbigene:608531
SAP18 GeneProduct ncbigene:609404
SIN3A GeneProduct ncbigene:478372
GLI1 GeneProduct ncbigene:481126
GAS1 GeneProduct ncbigene:607496
CREBBP GeneProduct ncbigene:479866
DYRK1A GeneProduct ncbigene:487755
STK36 GeneProduct ncbigene:478913
RAB23 GeneProduct ncbigene:481854
IGF2 GeneProduct ncbigene:483664
HHIP GeneProduct ncbigene:475452

References

  1. Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila. Mohler J. Genetics. 1988 Dec;120(4):1061–72. PubMed Europe PMC Scholia
  2. The Hedgehog response network: sensors, switches, and routers. Lum L, Beachy PA. Science. 2004 Jun 18;304(5678):1755–9. PubMed Europe PMC Scholia