EPO receptor signaling (WP1112)

Canis familiaris

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. ''Source: [[wikipedia:Erythropoietin_receptor|Wikipedia]]'' This pathway is based on ScienceSlides.

Authors

Thomas Kelder , Christine Chichester , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Canis familiaris

Communities

Annotations

Pathway Ontology

erythropoietin signaling pathway

Participants

Label Type Compact URI Comment
EPOR GeneProduct ncbigene:484943
JAK2 GeneProduct ncbigene:484185
SRC GeneProduct ncbigene:485864
STAT1 GeneProduct ncbigene:488449
SHC1 GeneProduct ncbigene:490439
GRB2 GeneProduct ncbigene:483312
MAP2K1 GeneProduct ncbigene:478347
MAPK3 GeneProduct ncbigene:486758
MAPK1 GeneProduct ncbigene:477575
MAP2K2 GeneProduct ncbigene:611939
PDK1 GeneProduct ncbigene:476828
AKT1 GeneProduct ncbigene:490878
PIK3CG GeneProduct ncbigene:483266
EPO GeneProduct ncbigene:404002
SOCS1 GeneProduct ncbigene:490006
STAT5B GeneProduct ncbigene:490969
CISH GeneProduct ncbigene:484757
STAT5A GeneProduct ncbigene:490968
STAT3 GeneProduct ncbigene:490967
PTPRC GeneProduct ncbigene:490255
PTPRU GeneProduct ncbigene:487328
RAF1 GeneProduct ncbigene:484648
SOS1 GeneProduct ncbigene:483042
IRS2 GeneProduct ncbigene:485548
IRS1 GeneProduct ncbigene:486148
RASA1 GeneProduct ncbigene:479158

References

  1. The molecular physiology of erythropoietin and the erythropoietin receptor. Zhu Y, D’Andrea AD. Curr Opin Hematol. 1994 Mar;1(2):113–8. PubMed Europe PMC Scholia
  2. The molecular biology of erythropoietin. Lacombe C, Mayeux P. Nephrol Dial Transplant. 1999;14 Suppl 2:22–8. PubMed Europe PMC Scholia