EPO receptor signaling (WP1112)

Canis familiaris

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The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. ''Source: [[wikipedia:Erythropoietin_receptor|Wikipedia]]'' This pathway is based on ScienceSlides.

Authors

Thomas Kelder , Christine Chichester , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Canis familiaris

Communities

Annotations

Pathway Ontology

erythropoietin signaling pathway

Participants

Label Type Compact URI Comment
EPOR GeneProduct ncbigene:484943
JAK2 GeneProduct ncbigene:484185
SRC GeneProduct ncbigene:485864
EPOR GeneProduct ncbigene:484943
STAT1 GeneProduct ncbigene:488449
SHC1 GeneProduct ncbigene:490439
GRB2 GeneProduct ncbigene:483312
MAP2K1 GeneProduct ncbigene:478347
MAPK3 GeneProduct ncbigene:486758
MAPK1 GeneProduct ncbigene:477575
MAP2K2 GeneProduct ncbigene:611939
PDK1 GeneProduct ncbigene:476828
AKT1 GeneProduct ncbigene:490878
PIK3CG GeneProduct ncbigene:483266
EPO GeneProduct ncbigene:404002
EPO GeneProduct ncbigene:404002
SOCS1 GeneProduct ncbigene:490006
STAT5B GeneProduct ncbigene:490969
CISH GeneProduct ncbigene:484757
STAT5A GeneProduct ncbigene:490968
STAT3 GeneProduct ncbigene:490967
STAT3 GeneProduct ncbigene:490967
STAT1 GeneProduct ncbigene:488449
PTPRC GeneProduct ncbigene:490255
PTPRU GeneProduct ncbigene:487328
GRB2 GeneProduct ncbigene:483312
RAF1 GeneProduct ncbigene:484648
SOS1 GeneProduct ncbigene:483042
IRS2 GeneProduct ncbigene:485548
JAK2 GeneProduct ncbigene:484185
IRS1 GeneProduct ncbigene:486148
RASA1 GeneProduct ncbigene:479158
RAF1 GeneProduct ncbigene:484648
SOS1 GeneProduct ncbigene:483042
RASA1 GeneProduct ncbigene:479158

References

  1. The molecular physiology of erythropoietin and the erythropoietin receptor. Zhu Y, D’Andrea AD. Curr Opin Hematol. 1994 Mar;1(2):113–8. PubMed Europe PMC Scholia
  2. The molecular biology of erythropoietin. Lacombe C, Mayeux P. Nephrol Dial Transplant. 1999;14 Suppl 2:22–8. PubMed Europe PMC Scholia