G1 to S cell cycle control (WP1078)
Bos taurus
In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&
Authors
Kristina Hanspers , Christine Chichester , and Martina Summer-KutmonActivity
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Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
cell cycle checkpoint pathway G1/S DNA damage checkpoint pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| RB1 | GeneProduct | ensembl:ENSBTAG00000006640 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5925 |
| E2F2 | GeneProduct | ensembl:ENSBTAG00000014400 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1870 |
| E2F1 | GeneProduct | ensembl:ENSBTAG00000003971 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1869 |
| POLE | GeneProduct | ensembl:ENSBTAG00000000590 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5426 |
| CDKN1B | GeneProduct | ensembl:ENSBTAG00000018254 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1027 |
| CDK6 | GeneProduct | ensembl:ENSBTAG00000044023 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1021 |
| PCNA | GeneProduct | ensembl:ENSBTAG00000006065 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5111 |
| CDK4 | GeneProduct | ensembl:ENSBTAG00000046091 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1019 |
| CDKN1A | GeneProduct | ensembl:ENSBTAG00000008353 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1026 |
| CDC45 | GeneProduct | ensembl:ENSBTAG00000004286 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8318 |
| CDKN2A | GeneProduct | ensembl:ENSBTAG00000034220 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1029 |
| CDK1 | GeneProduct | ensembl:ENSBTAG00000010109 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:983 |
| TP53 | GeneProduct | ensembl:ENSBTAG00000001069 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7157 |
| PRIM2 | GeneProduct | ensembl:ENSBTAG00000007937 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5558 |
| CDKN1C | GeneProduct | ensembl:ENSBTAG00000031184 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1028 |
| CCND2 | GeneProduct | ensembl:ENSBTAG00000016649 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:894 |
| E2F5 | GeneProduct | ensembl:ENSBTAG00000009378 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1875 |
| CCNE1 | GeneProduct | ensembl:ENSBTAG00000004735 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:898 |
| CREB3L4 | GeneProduct | ensembl:ENSBTAG00000014692 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:148327 |
| CDKN2B | GeneProduct | ensembl:ENSBTAG00000016412 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1030 |
| MDM2 | GeneProduct | ensembl:ENSBTAG00000010422 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4193 |
| CDK7 | GeneProduct | ensembl:ENSBTAG00000011046 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1022 |
| CCNG2 | GeneProduct | ensembl:ENSBTAG00000021768 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:901 |
| RPA2 | GeneProduct | ensembl:ENSBTAG00000006225 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6118 |
| CDK2 | GeneProduct | ensembl:ENSBTAG00000004021 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1017 |
| E2F4 | GeneProduct | ensembl:ENSBTAG00000012063 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1874 |
| CDKN2D | GeneProduct | ensembl:ENSBTAG00000010731 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1032 |
| CREB3 | GeneProduct | ensembl:ENSBTAG00000011429 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:10488 |
| CREB3L3 | GeneProduct | ensembl:ENSBTAG00000010215 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:84699 |
| MYT1 | GeneProduct | ensembl:ENSBTAG00000006352 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4661 |
| TFDP2 | GeneProduct | ensembl:ENSBTAG00000006222 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7029 |
| CCNB1 | GeneProduct | ensembl:ENSBTAG00000014239 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:891 |
| CCND3 | GeneProduct | ensembl:ENSBTAG00000010106 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:896 |
| CCND1 | GeneProduct | ensembl:ENSBTAG00000017514 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:595 |
| CCNH | GeneProduct | ensembl:ENSBTAG00000011650 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:902 |
| MYC | GeneProduct | ensembl:ENSBTAG00000008409 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4609 |
| RPA3 | GeneProduct | ensembl:ENSBTAG00000013168 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6119 |
| MCM4 | GeneProduct | ensembl:ENSBTAG00000046325 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4173 |
| MCM3 | GeneProduct | ensembl:ENSBTAG00000010721 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4172 |
| ATF6B | GeneProduct | ensembl:ENSBTAG00000008794 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1388 |
| ORC1 | GeneProduct | ensembl:ENSBTAG00000002719 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4998 |
| MCM6 | GeneProduct | ensembl:ENSBTAG00000015172 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4175 |
| MCM7 | GeneProduct | ensembl:ENSBTAG00000030965 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4176 |
| MCM2 | GeneProduct | ensembl:ENSBTAG00000014380 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4171 |
| ORC3 | GeneProduct | ensembl:ENSBTAG00000016969 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:23595 |
| CDKN2C | GeneProduct | ensembl:ENSBTAG00000011059 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1031 |
| POLE2 | GeneProduct | ensembl:ENSBTAG00000004931 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5427 |
| MNAT1 | GeneProduct | ensembl:ENSBTAG00000030801 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4331 |
| ORC6 | GeneProduct | ensembl:ENSBTAG00000001872 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:23594 |
| MCM5 | GeneProduct | ensembl:ENSBTAG00000015595 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4174 |
| E2F6 | GeneProduct | ensembl:ENSBTAG00000048286 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1876 |
| ORC2 | GeneProduct | ensembl:ENSBTAG00000031473 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:4999 |
| E2F3 | GeneProduct | ensembl:ENSBTAG00000021045 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1871 |
| TFDP1 | GeneProduct | ensembl:ENSBTAG00000019645 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7027 |
| RPA1 | GeneProduct | ensembl:ENSBTAG00000009711 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:6117 |
| CREB1 | GeneProduct | ensembl:ENSBTAG00000005474 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1385 |
| RBL1 | GeneProduct | ensembl:ENSBTAG00000011541 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5933 |
| WEE1 | GeneProduct | ensembl:ENSBTAG00000005278 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:7465 |
| ATM | GeneProduct | ensembl:ENSBTAG00000003111 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:472 |
| CREB3L1 | GeneProduct | ensembl:ENSBTAG00000006143 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:90993 |
| GADD45A | GeneProduct | ensembl:ENSBTAG00000013860 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:1647 |
| POLA2 | GeneProduct | ensembl:ENSBTAG00000011455 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:23649 |
| ORC4 | GeneProduct | ensembl:ENSBTAG00000015291 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5000 |
| PRIM1 | GeneProduct | ensembl:ENSBTAG00000044000 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5557 |
| CDC25A | GeneProduct | ensembl:ENSBTAG00000009586 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:993 |
| CCNA1 | GeneProduct | ensembl:ENSBTAG00000007284 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:8900 |
| ORC5 | GeneProduct | ensembl:ENSBTAG00000040058 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:5001 |
| CCNE2 | GeneProduct | ensembl:ENSBTAG00000004906 | Homology Mapping from Homo sapiens to Bos taurus: Original ID = L:9134 |
References
- GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA. J Invest Dermatol. 2002 Jul;119(1):22–6. PubMed Europe PMC Scholia