Integrin-mediated cell adhesion (WP1069)

Bos taurus

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Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: Wikipedia

Authors

Thomas Kelder , Daniela Digles , Martina Summer-Kutmon , Eric Weitz , and Kristina Hanspers

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

integrin mediated signaling pathway

Participants

Label Type Compact URI Comment
ITGA4 GeneProduct ensembl:ENSBTAG00000009256 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3676
ILK GeneProduct ensembl:ENSBTAG00000000696 ILK; integrin-linked kinase [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3611
PTK2 GeneProduct ensembl:ENSBTAG00000009578 PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5747
INTB3 GeneProduct ensembl:ENSBTAG00000009987 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3690
ITGAE GeneProduct ensembl:ENSBTAG00000015264 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3682
SOS1 GeneProduct ensembl:ENSBTAG00000011643 SOS1; son of sevenless homolog 1 (Drosophila)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6654
ZYX GeneProduct ensembl:ENSBTAG00000017970 ZYX; zyxin
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7791
RAP1A GeneProduct ensembl:ENSBTAG00000014710 RAP1A; RAP1A member of RAS oncogene family
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5906
ITGAM GeneProduct ensembl:ENSBTAG00000047238 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3684
CRK GeneProduct ensembl:ENSBTAG00000005665 CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1398
ITGA7 GeneProduct ensembl:ENSBTAG00000012897 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3679
bta-mir-34c GeneProduct ensembl:ENSBTAG00000029991 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207562
ITGB7 GeneProduct ensembl:ENSBTAG00000018993 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3695
MYPN GeneProduct ensembl:ENSBTAG00000017509 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138347
CAPN5 GeneProduct ensembl:ENSBTAG00000005034 CAPN5; calpain
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:726
ITGAD GeneProduct ensembl:ENSBTAG00000019524 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3681
ROCK1 GeneProduct ensembl:ENSBTAG00000008403 ROCK1; Rho-associated coiled-coil containing protein kinase
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6093
ITGAV GeneProduct ensembl:ENSBTAG00000019929 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3685
ITGA3 GeneProduct ensembl:ENSBTAG00000019498 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3675
VCL GeneProduct ensembl:ENSBTAG00000021879 VCL; vinculin
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7414
RAPGEF1 GeneProduct ensembl:ENSBTAG00000020791 GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2889
ITGA2B GeneProduct ensembl:ENSBTAG00000008165 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3674
CAPN6 GeneProduct ensembl:ENSBTAG00000000828 CAPN6; calpain 6 [EC:3.4.22.17]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:827
RAC2 GeneProduct ensembl:ENSBTAG00000011043 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5880
PXN GeneProduct ensembl:ENSBTAG00000018108 PXN; paxillin
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5829
PAK6 GeneProduct ensembl:ENSBTAG00000019076 PAK6; p21(CDKN1A)-activated kinase
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:56924
MAP2K1 GeneProduct ensembl:ENSBTAG00000033983 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
BCAR1 GeneProduct ensembl:ENSBTAG00000012002 BCAR1; breast cancer anti-estrogen resistance 1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9564
ITGB4 GeneProduct ensembl:ENSBTAG00000018169 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3691
ITGB8 GeneProduct ensembl:ENSBTAG00000003709 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3696
PDPK1 GeneProduct ensembl:ENSBTAG00000034436 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.1.37]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5170
CAPN3 GeneProduct ensembl:ENSBTAG00000008868 CAPN3; calpain 3 (p94) [EC:3.4.22.17]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:825
SRC GeneProduct ensembl:ENSBTAG00000008938 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
DOCK1 GeneProduct ensembl:ENSBTAG00000031890 DOCK1; dedicator of cyto-kinesis
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1793
VAV3 GeneProduct ensembl:ENSBTAG00000031575 VAV3; vav 3 oncogene
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10451
BRAF GeneProduct ensembl:ENSBTAG00000021761 BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:673
CAV2 GeneProduct ensembl:ENSBTAG00000045584 CAV2; caveolin 2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:858
ITGAL GeneProduct ensembl:ENSBTAG00000007103 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3683
ARAF GeneProduct ensembl:ENSBTAG00000005039 ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:369
CAPN11 GeneProduct ensembl:ENSBTAG00000021066 CAPN11; calpain 11 [EC:3.4.22.17]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11131
CAPN10 GeneProduct ensembl:ENSBTAG00000002809 CAPN10; calpain 10 [EC:3.4.22.17
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11132
ITGA1 GeneProduct ensembl:ENSBTAG00000016525 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3672
FYN GeneProduct ensembl:ENSBTAG00000011851 FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2534
MAPK10 GeneProduct ensembl:ENSBTAG00000020048 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5602
CSK GeneProduct ensembl:ENSBTAG00000021424 CSK; c-src tyrosine kinase [EC:2.7.1.112]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1445
CAV3 GeneProduct ensembl:ENSBTAG00000022699 CAV3; caveolin 3
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:859
RHO GeneProduct ensembl:ENSBTAG00000001310 RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6010
HRAS GeneProduct ensembl:ENSBTAG00000046644 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
MAPK7 GeneProduct ensembl:ENSBTAG00000001014 MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5598
CAV1 GeneProduct ensembl:ENSBTAG00000017869 CAV1; caveolin 1 caveolae protein 22kD
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:857
ITGB6 GeneProduct ensembl:ENSBTAG00000009080 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3694
MAPK6 GeneProduct ensembl:ENSBTAG00000005865 MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5597
SHC1 GeneProduct ensembl:ENSBTAG00000019838 SHC1; SHC (Src homology 2 domain containing) transforming protein 1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6464
ITGB1 GeneProduct ensembl:ENSBTAG00000015910 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3688
CAPN2 GeneProduct ensembl:ENSBTAG00000012778 CAPN2; calpain 2 (m/II) large subunit [EC:3.4.22.17]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:824
AKT3 GeneProduct ensembl:ENSBTAG00000017788 AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10000
MAP2K2 GeneProduct ensembl:ENSBTAG00000024450 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
ITGA9 GeneProduct ensembl:ENSBTAG00000016566 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3680
TNS1 GeneProduct ensembl:ENSBTAG00000002485 TNS; tensi
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7145
CAPN7 GeneProduct ensembl:ENSBTAG00000006479 CAPN7; calpain 7 [EC:3.4.22.17
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23473
ITGA5 GeneProduct ensembl:ENSBTAG00000013745 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3678
ITGA10 GeneProduct ensembl:ENSBTAG00000008373 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8515
RAF1 GeneProduct ensembl:ENSBTAG00000045748 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
VAV2 GeneProduct ensembl:ENSBTAG00000004511 VAV2; vav 2 oncogene
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7410
CDC42 GeneProduct ensembl:ENSBTAG00000001700 CDC42; cell division cycle 42 (GTP binding protein 25kD)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:998
MAP2K5 GeneProduct ensembl:ENSBTAG00000000218 MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5607
CAPNS1 GeneProduct ensembl:ENSBTAG00000014872 CAPNS1; calpain small subunit 1 [EC:3.4.22.17]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:826
ITGB2 GeneProduct ensembl:ENSBTAG00000017060 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3689
PAK2 GeneProduct ensembl:ENSBTAG00000047856 PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5062
MAP2K3 GeneProduct ensembl:ENSBTAG00000010576 MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606
MAPK1 GeneProduct ensembl:ENSBTAG00000010312 MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
SORBS1 GeneProduct ensembl:ENSBTAG00000002880 SH3D5; SH3-domain protein 5 (ponsin
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10580
RAP1B GeneProduct ensembl:ENSBTAG00000008967 RAP1B; RAP1B member of RAS oncogene family
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5908
MAP2K6 GeneProduct ensembl:ENSBTAG00000001609 MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5608
PAK3 GeneProduct ensembl:ENSBTAG00000015670 PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5063
ITGA2 GeneProduct ensembl:ENSBTAG00000019289 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3673
AKT2 GeneProduct ensembl:ENSBTAG00000001400 AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:208
CAPN1 GeneProduct ensembl:ENSBTAG00000010230 CAPN1; calpain 1 (mu/I) large subunit [EC:3.4.22.17]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:823
RAC1 GeneProduct ensembl:ENSBTAG00000009233 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879
ROCK2 GeneProduct ensembl:ENSBTAG00000005847 ROCK2; Rho-associated coiled-coil containing protein kinase
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9475
GIT2 GeneProduct ensembl:ENSBTAG00000006506 GIT2; G protein-coupled receptor kinase-interactor 2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9815
VASP GeneProduct ensembl:ENSBTAG00000019604 VASP; vasodilator-stimulated phosphoprotein
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7408
ITGA6 GeneProduct ensembl:ENSBTAG00000017266 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3655
PAK1 GeneProduct ensembl:ENSBTAG00000010191 PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5058
AKT1 GeneProduct ensembl:ENSBTAG00000017636 AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
GRB2 GeneProduct ensembl:ENSBTAG00000004736 GRB2; growth factor receptor-bound protein 2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2885
ITGB5 GeneProduct ensembl:ENSBTAG00000013755 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3693
ITGA8 GeneProduct ensembl:ENSBTAG00000007602 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8516
ITGA11 GeneProduct ensembl:ENSBTAG00000008380 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:22801
ARHGEF7 GeneProduct ensembl:ENSBTAG00000020726 ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8874
MYLK2 GeneProduct ensembl:ENSBTAG00000014930 MYLK2; myosin light chain kinase 2 skeletal muscle [EC:2.7.1.117
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:85366
PAK4 GeneProduct ensembl:ENSBTAG00000013958 PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10298
MAPK4 GeneProduct ensembl:ENSBTAG00000009907 MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5596
MAPK12 GeneProduct ensembl:ENSBTAG00000019574 MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6300
RAC3 GeneProduct ensembl:ENSBTAG00000022927 RAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5881
TLN1 GeneProduct ensembl:ENSBTAG00000025868 TLN1; talin 1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7094
SHC3 GeneProduct ensembl:ENSBTAG00000011375 SHC3; neuronal Sh
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:53358

References

  1. Assembly and signaling of adhesion complexes. Sepulveda JL, Gkretsi V, Wu C. Curr Top Dev Biol. 2005;68:183–225. PubMed Europe PMC Scholia
  2. The miR-34 family in cancer and apoptosis. Hermeking H. Cell Death Differ. 2010 Feb;17(2):193–9. PubMed Europe PMC Scholia