Matrix metalloproteinases (WP1060)

Bos taurus

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Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily. Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense. Source: Wikipedia

Authors

Thomas Kelder , Daniela Digles , Martina Summer-Kutmon , Eric Weitz , and Kristina Hanspers

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

protein degradation pathway cell-extracellular matrix signaling pathway

Participants

Label Type Compact URI Comment
MMP23B GeneProduct ensembl:ENSBTAG00000010732 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8510
MMP27 GeneProduct ensembl:ENSBTAG00000040567 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64066
MMP2 GeneProduct ensembl:ENSBTAG00000019267 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4313
MMP11 GeneProduct ensembl:ENSBTAG00000006108 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4320
MMP15 GeneProduct ensembl:ENSBTAG00000012919 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4324
MMP25 GeneProduct ensembl:ENSBTAG00000016424 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64386
MMP9 GeneProduct ensembl:ENSBTAG00000020676 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4318
MMP3 GeneProduct ensembl:ENSBTAG00000037768 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4314
MMP28 GeneProduct ensembl:ENSBTAG00000006086 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:79148
TIMP2 GeneProduct ensembl:ENSBTAG00000010899 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7077
MMP7 GeneProduct ensembl:ENSBTAG00000004594 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4316
MMP10 GeneProduct ensembl:ENSBTAG00000037768 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4319
MMP17 GeneProduct ensembl:ENSBTAG00000002145 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4326
MMP19 GeneProduct ensembl:ENSBTAG00000009051 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4327
BSG GeneProduct ensembl:ENSBTAG00000016648 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:682
MMP-16 GeneProduct ensembl:ENSBTAG00000006877 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4325
TCF20 GeneProduct ensembl:ENSBTAG00000000662 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6942
MMP14 GeneProduct ensembl:ENSBTAG00000014824 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4323
MMP20 GeneProduct ensembl:ENSBTAG00000014251 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9313
TIMP1 GeneProduct ensembl:ENSBTAG00000005043 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7076
MMP8 GeneProduct ensembl:ENSBTAG00000046732 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4317
MMP13 GeneProduct ensembl:ENSBTAG00000015059 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4322
TIMP3 GeneProduct ensembl:ENSBTAG00000020638 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7078
MMP24 GeneProduct ensembl:ENSBTAG00000010024 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10893
TNF GeneProduct ensembl:ENSBTAG00000025471 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7124
MMP1 GeneProduct ensembl:ENSBTAG00000048029 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4312
TIMP4 GeneProduct ensembl:ENSBTAG00000020263 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7079

References

  1. Matrix metalloproteinases: effectors of development and normal physiology. Vu TH, Werb Z. Genes Dev. 2000 Sep 1;14(17):2123–33. PubMed Europe PMC Scholia