wikipathways-collection

WikiPathways WP5094

• WikiPathways: WP5094 (classic)
• Species: Homo sapiens
• Scholia: WP5094

  Tests

• CASMetabolitesTests: all 2 tests OK!
• ChEBIMetabolitesTests: all 5 tests OK!
• ChemSpiderTests: all 2 tests OK!
• DataNodesTests
  • dataNodesWithoutIdentifier: .x we found 1 problem(s):
    • The following DataNodes have no identifier: 2
  • unknownTypes_knownDatasource: .. all OK!
  • unknownTypes: .. all OK!
  • unknownTypes_Reactome: .. all OK!
  • otherDataSource: .. all OK!
• EnsemblTests: all 4 tests OK!
• GeneTests: all 4 tests OK!
• GeneralTests: all 15 tests OK!
• HMDBSecMetabolitesTests: all 3 tests OK!
• InteractionTests
  • noMetaboliteToNonMetaboliteConversions: .. all OK!
  • noNonMetaboliteToMetaboliteConversions: .. all OK!
  • noGeneProteinConversions: .. all OK!
  • nonNumericIDs: .. all OK!
  • interactionsWithLabels: .x we found 1 problem(s):
    • Interactions found that involve Labels: 27
  • possibleTranslocations: .x we found 1 problem(s):
    • Interactions between identical nodes: 9
  • noProteinProteinConversions: .. all OK!
  • incorrectKEGGIdentifiers: .. all OK!
• KEGGMetaboliteTests: all 2 tests OK!
• LIPIDMAPSTests: all 1 tests OK!
• MetaboliteStructureTests: all 1 tests OK!
• MetabolitesTests: all 14 tests OK!
• OudatedDataSourcesTests: all 24 tests OK!
• PathwayTests: all 7 tests OK!
• ProteinsTests: all 2 tests OK!
• PubChemMetabolitesTests: all 3 tests OK!
• ReferencesTests: all 6 tests OK!
• UniProtTests: all 5 tests OK!
• WikidataTests: all 4 tests OK!

Summary

• Number of test classes: 20
• Number of tests: 117
• Number of assertions: 235
• Number of fails: 3

Fails

Data nodes without an identifier

The following DataNodes have no identifier: 2

• http://classic.wikipathways.org/instance/WP5094_r135195 http://rdf.wikipathways.org/Pathway/WP5094_r135195/DataNode/be77e (Glucose metabolism)
• http://classic.wikipathways.org/instance/WP5094_r135195 http://rdf.wikipathways.org/Pathway/WP5094_r135195/DataNode/b3c43 (IP1)

More details at https://www.wikipathways.org/WikiPathwaysCurator/DataNodesTests/dataNodesWithoutIdentifier

InteractionTests.interactionsWithLabels

Interactions found that involve Labels: 27

http://classic.wikipathways.org/instance/WP5094_r135195 "SRC 
family" with graphId fc1c7
http://classic.wikipathways.org/instance/WP5094_r135195 "In pre- and
differentiated 
3T3-L1 adipocytes" with graphId e4818
http://classic.wikipathways.org/instance/WP5094_r135195 "Cell death
in HCRTR1-
transfected
CHO-K1 cells
" with graphId eb13a
http://classic.wikipathways.org/instance/WP5094_r135195 "Anti-inflammatory
response of orexin
in Intracerebral
hemorrhage" with graphId f7a0a
http://classic.wikipathways.org/instance/WP5094_r135195 "Regulation of
Mesenchymal
Stem Cell
Differentiation" with graphId b2372
http://classic.wikipathways.org/instance/WP5094_r135195 "In subcutaneous
HCRTR1 and R2
mRNA expressing
adipose tissue
explants" with graphId b3688
http://classic.wikipathways.org/instance/WP5094_r135195 "Adenylate
cyclase" with graphId cff6b
http://classic.wikipathways.org/instance/WP5094_r135195 "Orexin B" with graphId fa3e7
http://classic.wikipathways.org/instance/WP5094_r135195 "In cortical
neurons" with graphId dd1ff
http://classic.wikipathways.org/instance/WP5094_r135195 "Increased
glucose
utilization in
hypothalamic
neurons" with graphId a1342
http://classic.wikipathways.org/instance/WP5094_r135195 "Catecholamine
biosynthesis
in adrenal
medullary cells" with graphId e6e90
http://classic.wikipathways.org/instance/WP5094_r135195 "Activation
of PDH and
Mitochondrial
glucose
oxidation in
Hep3B/G2 cells" with graphId f1b93
http://classic.wikipathways.org/instance/WP5094_r135195 "Promotes
osteogenic
differentiation
& mineralization" with graphId f456c
http://classic.wikipathways.org/instance/WP5094_r135195 "In differentiated 
3T3-L1 adipocytes" with graphId d166a
http://classic.wikipathways.org/instance/WP5094_r135195 " Apoptosis in
 OX1R+ HT29-D4, 
 SK-N-MC, C6 &
 CHO cell lines" with graphId e6121
http://classic.wikipathways.org/instance/WP5094_r135195 "Regulation of
expression of
HCRTR1 in
INS-1 cells" with graphId e2a87
http://classic.wikipathways.org/instance/WP5094_r135195 "Activation
of PDH and 
Suppresion
of lactate 
production
in adipocytes" with graphId fe496
http://classic.wikipathways.org/instance/WP5094_r135195 "In anoxia /
hypoglycemic
astrocytes" with graphId a6dd7
http://classic.wikipathways.org/instance/WP5094_r135195 "In anoxia /
hypoglycemic
astrocytes" with graphId bd78b
http://classic.wikipathways.org/instance/WP5094_r135195 " Sustained 
 HCRTR1-ARRB2
 interaction 
 prolonged
 MAPK1/3
 activation
 in HEK-293T
 HCRTR1+ cells" with graphId d3ae3
http://classic.wikipathways.org/instance/WP5094_r135195 " Regulation
 of receptor
 internalization" with graphId d26fd
http://classic.wikipathways.org/instance/WP5094_r135195 "Potential
regulation of
hypothalamic-
pituitary-
gonadal axis" with graphId f3274
http://classic.wikipathways.org/instance/WP5094_r135195 "Orexin A" with graphId c303e
http://classic.wikipathways.org/instance/WP5094_r135195 "Neuro-
protective
effect" with graphId ee1d7
http://classic.wikipathways.org/instance/WP5094_r135195 "Increased HCRTR1
expression 
counteracts
testosterone-
induced nuclear
transloaction of
Androgen Receptor
in LnCaP cells" with graphId e3094
http://classic.wikipathways.org/instance/WP5094_r135195 "Regulation of
expression of
HCRTR1/2 in
leuteal cells" with graphId ed19b
http://classic.wikipathways.org/instance/WP5094_r135195 "Regulation of
expression of
HCRTR1/2 in
Primary anterior
pituatory cells" with graphId d8fe3

Possible MIM translocation

Interactions between identical nodes: 9

http://classic.wikipathways.org/instance/WP5094_r135195 http://rdf.wikipathways.org/Pathway/WP5094_r135195/WP/Interaction/e194f "Ca2+" (https://identifiers.org/kegg.compound/C00076) and 
Ca2+" (https://identifiers.org/kegg.compound/C00076)
http://classic.wikipathways.org/instance/WP5094_r135195 http://rdf.wikipathways.org/Pathway/WP5094_r135195/WP/Interaction/dcd76 "Glucose" (https://identifiers.org/kegg.compound/C00031) and 
Glucose" (https://identifiers.org/kegg.compound/C00031)
http://classic.wikipathways.org/instance/WP5094_r135195 http://rdf.wikipathways.org/Pathway/WP5094_r135195/WP/Interaction/c3d6f "Glutamic acid" (https://identifiers.org/kegg.compound/C00025) and 
Glutamic acid" (https://identifiers.org/kegg.compound/C00025)
http://classic.wikipathways.org/instance/WP5094_r135195 http://rdf.wikipathways.org/Pathway/WP5094_r135195/WP/Interaction/c3d6f "Glutamic acid" (https://identifiers.org/kegg.compound/C00025) and 
Glutamic acid  uptake" (https://identifiers.org/kegg.compound/C00025)
http://classic.wikipathways.org/instance/WP5094_r135195 http://rdf.wikipathways.org/Pathway/WP5094_r135195/WP/Interaction/c3d6f "Glutamic acid  uptake" (https://identifiers.org/kegg.compound/C00025) and 
Glutamic acid" (https://identifiers.org/kegg.compound/C00025)
http://classic.wikipathways.org/instance/WP5094_r135195 http://rdf.wikipathways.org/Pathway/WP5094_r135195/WP/Interaction/c3d6f "Glutamic acid  uptake" (https://identifiers.org/kegg.compound/C00025) and 
Glutamic acid  uptake" (https://identifiers.org/kegg.compound/C00025)
http://classic.wikipathways.org/instance/WP5094_r135195 http://rdf.wikipathways.org/Pathway/WP5094_r135195/WP/Interaction/a55b0 "Cytochrome C" (https://identifiers.org/kegg.compound/C00125) and 
Cytochrome C" (https://identifiers.org/kegg.compound/C00125)
http://classic.wikipathways.org/instance/WP5094_r135195 http://rdf.wikipathways.org/Pathway/WP5094_r135195/WP/Interaction/a76e3 "Glucose" (https://identifiers.org/kegg.compound/C00031) and 
Glucose" (https://identifiers.org/kegg.compound/C00031)
http://classic.wikipathways.org/instance/WP5094_r135195 http://rdf.wikipathways.org/Pathway/WP5094_r135195/WP/Interaction/aeb21 "Ca2+" (https://identifiers.org/kegg.compound/C00076) and 
Ca2+" (https://identifiers.org/kegg.compound/C00076)

More details at https://www.wikipathways.org/WikiPathwaysCurator/InteractionTests/possibleTranslocations