IL-3 signaling pathway (WP373)

Mus musculus

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads

Interleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common beta chain, which is shared between all members of this cytokine family. Binding of IL-3 to IL3RA recruits the beta chain to the complex, which activates the JAK/STAT, MAPK and PI 3-kinase signaling modules. Source: NetPath

For a description of pathway objects, see the WikiPathways Legend.

Authors

Akhilesh Pandey , Christine Chichester , Eric Weitz , and Egon Willighagen

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

interleukin-3 signaling pathway

Participants

Label Type Compact URI Comment
IL3 GeneProduct ncbigene:16187
Stat1 GeneProduct ncbigene:20846
Raf1 GeneProduct ncbigene:110157
Stat5a GeneProduct ncbigene:20850
Fcer2a GeneProduct ncbigene:14128
Slc2a1 GeneProduct ncbigene:20525
Kcnip3 GeneProduct ncbigene:56461
Cbl GeneProduct ncbigene:12402
Ptpn6 GeneProduct ncbigene:15170
Atf2 GeneProduct ncbigene:11909
Shc1 GeneProduct ncbigene:20416
Mapk7 GeneProduct ncbigene:23939
Jak2 GeneProduct ncbigene:16452
Pxn GeneProduct ncbigene:19303
Ywhaz GeneProduct ncbigene:22631
Vcl GeneProduct ncbigene:22330
Stat6 GeneProduct ncbigene:20852
Gab1 GeneProduct ncbigene:14388
Tec GeneProduct ncbigene:21682
Tyk2 GeneProduct ncbigene:54721
Matk GeneProduct ncbigene:17179
Mapk1 GeneProduct ncbigene:26413
Ptk2 GeneProduct ncbigene:14083
Pik3cd GeneProduct ncbigene:18707
Gata2 GeneProduct ncbigene:14461
Pik3r1 GeneProduct ncbigene:18708
Lyn GeneProduct ncbigene:17096
Bad GeneProduct ncbigene:12015
Bcl2l11 GeneProduct ncbigene:12125
Grb2 GeneProduct ncbigene:14784
CSF2RB GeneProduct ncbigene:12983
Sos1 GeneProduct ncbigene:20662
ATF1 GeneProduct ncbigene:11908
Vav1 GeneProduct ncbigene:22324
Chek1 GeneProduct ncbigene:12649
Crk GeneProduct ncbigene:12928
Jak1 GeneProduct ncbigene:16451
Stat3 GeneProduct ncbigene:20848
Prkca GeneProduct ncbigene:18750
Id1 GeneProduct ncbigene:15901
Gnb2l1 GeneProduct ncbigene:14694
Mapk8 GeneProduct ncbigene:26419
Gab2 GeneProduct ncbigene:14389
Stat5b GeneProduct ncbigene:20851
Prkaca GeneProduct ncbigene:18747
Bmx GeneProduct ncbigene:12169
Lck GeneProduct ncbigene:16818
Ywhab GeneProduct ncbigene:54401
Mapk3 GeneProduct ncbigene:26417
Gm2423 GeneProduct ncbigene:100039786
Dnm1 GeneProduct ncbigene:13429
Birc5 GeneProduct ncbigene:11799
Mapk14 GeneProduct ncbigene:26416
Il3ra GeneProduct ncbigene:16188
Ppp2ca GeneProduct ncbigene:19052
Akt1 GeneProduct ncbigene:11651
Nfkb1 GeneProduct ncbigene:18033
Rps6kb2 GeneProduct ncbigene:58988
Gsk3b GeneProduct ncbigene:56637
Tnfrsf1b GeneProduct ncbigene:21938
Bcl2 GeneProduct ncbigene:12043
Sfpi1 GeneProduct ncbigene:20375
Prkcb GeneProduct ncbigene:18751
Gata1 GeneProduct ncbigene:14460
Mras GeneProduct ncbigene:17532
Kras GeneProduct ncbigene:16653
Mmp9 GeneProduct ncbigene:17395
Ptpn11 GeneProduct ncbigene:19247
Creb1 GeneProduct ncbigene:12912
Rap1a GeneProduct ncbigene:109905
Rara GeneProduct ncbigene:19401
Syk GeneProduct ncbigene:20963
Src GeneProduct ncbigene:20779
Pik3ca GeneProduct ncbigene:18706
Bax GeneProduct ncbigene:12028
Mapkapk2 GeneProduct ncbigene:17164
Cish GeneProduct ncbigene:12700
Pik3r2 GeneProduct ncbigene:18709
Mapk9 GeneProduct ncbigene:26420
Hspb1 GeneProduct ncbigene:15507
Inpp5d GeneProduct ncbigene:16331
Crkl GeneProduct ncbigene:12929
Fes GeneProduct ncbigene:14159
Hras1 GeneProduct ncbigene:15461
Rac2 GeneProduct ncbigene:19354
Rapgef1 GeneProduct ncbigene:107746
Selp GeneProduct ncbigene:20344
Gsk3a GeneProduct ncbigene:606496
Foxo1 GeneProduct ncbigene:56458
Pak1 GeneProduct ncbigene:18479
SOCS2 GeneProduct ncbigene:216233
Rxra GeneProduct ncbigene:20181
Map2k1 GeneProduct ncbigene:26395
Hck GeneProduct ncbigene:15162
Mmp2 GeneProduct ncbigene:17390
Socs3 GeneProduct ncbigene:12702
Rac1 GeneProduct ncbigene:19353
Bcl2l1 GeneProduct ncbigene:12048
CDC42 GeneProduct ncbigene:12540
Fyn GeneProduct ncbigene:14360

References