Heart development (WP3280)

Bos taurus

This pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impact the regional specificity of the human heart. Activating signals are indicated by arrows while inhibitory signals are indicated by T-bars. Special thanks to Kim Cordes for her assistance in revising this pathway, based on recent heart development research.

Authors

Martina Summer-Kutmon , Jonathan Mélius , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Cell Type Ontology

smooth muscle cell neural crest derived vascular associated smooth muscle cell

Disease Ontology

heart disease

Pathway Ontology

regulatory pathway

Participants

Label Type Compact URI Comment
TBX20 GeneProduct ensembl:ENSBTAG00000017541 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57057
TBX2 GeneProduct ensembl:ENSBTAG00000014278 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6909
NKX2-5 GeneProduct ensembl:ENSBTAG00000020568 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1482
TBX5 GeneProduct ensembl:ENSBTAG00000011384 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6910
BMP10 GeneProduct ensembl:ENSBTAG00000000992 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27302
HAND1 GeneProduct ensembl:ENSBTAG00000002335 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9421
IRX4 GeneProduct ensembl:ENSBTAG00000015907 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:50805
NKX2-5 GeneProduct ensembl:ENSBTAG00000020568 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1482
FOXH1 GeneProduct ensembl:ENSBTAG00000004761 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8928
MEF2C GeneProduct ensembl:ENSBTAG00000020701 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4208
SMYD1 GeneProduct ensembl:ENSBTAG00000021120 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:150572
TBX20 GeneProduct ensembl:ENSBTAG00000017541 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57057
HAND2 GeneProduct ensembl:ENSBTAG00000044123 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9464
NOTCH1 GeneProduct ensembl:ENSBTAG00000022799 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4851
HEY1 GeneProduct ensembl:ENSBTAG00000015717 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23462
SRF GeneProduct ensembl:ENSBTAG00000012777 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6722
GATA4 GeneProduct ensembl:ENSBTAG00000005425 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2626
ISL1 GeneProduct ensembl:ENSBTAG00000001241 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3670
bta-mir-1-1 GeneProduct ensembl:ENSBTAG00000029790 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000199017
HEY2 GeneProduct ensembl:ENSBTAG00000000919 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23493
SHH GeneProduct ensembl:ENSBTAG00000024552 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6469
FOXA2 GeneProduct ensembl:ENSBTAG00000012407 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3170
FOXC2 GeneProduct ensembl:ENSBTAG00000012465 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2303
NKX2-5 GeneProduct ensembl:ENSBTAG00000020568 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1482
PITX2 GeneProduct ensembl:ENSBTAG00000009059 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5308
FGF8 GeneProduct ensembl:ENSBTAG00000001530 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2253
TBX5 GeneProduct ensembl:ENSBTAG00000011384 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6910
BMP2 GeneProduct ensembl:ENSBTAG00000005111 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:650
TBX2 GeneProduct ensembl:ENSBTAG00000014278 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6909
PTPN11 GeneProduct ensembl:ENSBTAG00000002048 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781
NFATC1 GeneProduct ensembl:ENSBTAG00000000656 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4772
VEGFA GeneProduct ensembl:ENSBTAG00000047561 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7422
NFATC2 GeneProduct ensembl:ENSBTAG00000018270 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4773
NFATC3 GeneProduct ensembl:ENSBTAG00000004368 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4775
NFATC4 GeneProduct ensembl:ENSBTAG00000006366 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4776
VEGFB GeneProduct ensembl:ENSBTAG00000047567 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7423
VEGFC GeneProduct ensembl:ENSBTAG00000014737 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7424
NKX2-5 GeneProduct ensembl:ENSBTAG00000020568 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1482
TBX5 GeneProduct ensembl:ENSBTAG00000011384 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6910
GATA4 GeneProduct ensembl:ENSBTAG00000005425 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2626
CTNNB1 GeneProduct ensembl:ENSBTAG00000016420 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1499
NOTCH1 GeneProduct ensembl:ENSBTAG00000022799 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4851
BHLHE40 GeneProduct ensembl:ENSBTAG00000009863 In other species, this is BHLHB2
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8553
SMAD1 GeneProduct ensembl:ENSBTAG00000002835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4086
SMAD4 GeneProduct ensembl:ENSBTAG00000006919 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4089
BMP4 GeneProduct ensembl:ENSBTAG00000003835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:652
BMPR-IA GeneProduct ensembl:ENSBTAG00000000231 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:657
BMPRII GeneProduct ensembl:ENSBTAG00000006420 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:659
BMP2 GeneProduct ensembl:ENSBTAG00000005111 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:650
GATA6 GeneProduct ensembl:ENSBTAG00000005734 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2627
MEF2C GeneProduct ensembl:ENSBTAG00000020701 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4208
SRF GeneProduct ensembl:ENSBTAG00000012777 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6722
NKX2-5 GeneProduct ensembl:ENSBTAG00000020568 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1482
bta-mir-143 GeneProduct ensembl:ENSBTAG00000030114 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000208035
GATA4 GeneProduct ensembl:ENSBTAG00000005425 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2626
ERBB3 GeneProduct ensembl:ENSBTAG00000010444 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2065
MAPK1 GeneProduct ensembl:ENSBTAG00000010312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
TBX5 GeneProduct ensembl:ENSBTAG00000011384 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6910
MEF2C GeneProduct ensembl:ENSBTAG00000020701 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4208
GATA4 GeneProduct ensembl:ENSBTAG00000005425 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2626

References

  1. Development of heart valves requires Gata4 expression in endothelial-derived cells. Rivera-Feliciano J, Lee KH, Kong SW, Rajagopal S, Ma Q, Springer Z, et al. Development. 2006 Sep;133(18):3607–18. PubMed Europe PMC Scholia
  2. Making or breaking the heart: from lineage determination to morphogenesis. Srivastava D. Cell. 2006 Sep 22;126(6):1037–48. PubMed Europe PMC Scholia
  3. An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Prall OWJ, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, et al. Cell. 2007 Mar 9;128(5):947–59. PubMed Europe PMC Scholia
  4. BMP and BMP receptor expression during murine organogenesis. Danesh SM, Villasenor A, Chong D, Soukup C, Cleaver O. Gene Expr Patterns. 2009 Jun;9(5):255–65. PubMed Europe PMC Scholia
  5. Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner. Fulcoli FG, Huynh T, Scambler PJ, Baldini A. PLoS One. 2009 Jun 25;4(6):e6049. PubMed Europe PMC Scholia
  6. miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, et al. Nature. 2009 Aug 6;460(7256):705–10. PubMed Europe PMC Scholia
  7. A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Kwon C, Qian L, Cheng P, Nigam V, Arnold J, Srivastava D. Nat Cell Biol. 2009 Aug;11(8):951–7. PubMed Europe PMC Scholia