RalA downstream regulated genes (WP3268)

Bos taurus

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Downstream genes of RalA signaling pathways, including the Rac-family GTPase-activating protein RLIP (also known as RLIP76 and ralA binding protein 1 (RALBP1)), CDC42(cell division cycle 42), RAC1 (ras-related C3 botulinum toxin substrate 1), RAC2, RAC3, the Y-box transcription factor ZO-1-associated nucleic acidbinding protein (ZONAB, also known as cold shock domain protein A (CSDA)), and two subunits of the exocyst complex, SEC5 (also known as exocyst complex component 2 (EXOC2)) and EXO84 (also known as EXOC8), which are involved in regulating cell proliferation, apoptosis and migration

Authors

Martina Summer-Kutmon

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

Ras family mediated signaling pathway

Disease Ontology

chronic myeloid leukemia

Participants

Label Type Compact URI Comment
CSDA GeneProduct ensembl:ENSBTAG00000009663 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8531
EXOC2 GeneProduct ensembl:ENSBTAG00000020215 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55770
EXOC8 GeneProduct ensembl:ENSBTAG00000006111 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:149371
RALBP1 GeneProduct ensembl:ENSBTAG00000021250 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10928
CDC42 GeneProduct ensembl:ENSBTAG00000001700 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:998
RAC3 GeneProduct ensembl:ENSBTAG00000022927 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5881
RAC2 GeneProduct ensembl:ENSBTAG00000011043 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5880
RAC1 GeneProduct ensembl:ENSBTAG00000009233 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5879
HRAS GeneProduct ensembl:ENSBTAG00000046644 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
NRAS GeneProduct ensembl:ENSBTAG00000046797 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4893
RALA GeneProduct ensembl:ENSBTAG00000006661 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5898

References

  1. miR-181a post-transcriptionally downregulates oncogenic RalA and contributes to growth inhibition and apoptosis in chronic myelogenous leukemia (CML). Fei J, Li Y, Zhu X, Luo X. PLoS One. 2012;7(3):e32834. PubMed Europe PMC Scholia