Metastatic brain tumor (WP3259)

Bos taurus

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Interaction between microRNAs (miRNAs) and abnormal methylation to control metastasis. Tumor growth and metastasis formation through down regulation of their oncogenic targets such as MYC ,E2F3 and cyclin-dependent kinase(CDK6).

Authors

Martina Summer-Kutmon and Elisa Cirillo

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

disease pathway

Disease Ontology

disease of cellular proliferation

Participants

Label Type Compact URI Comment
E2F3 GeneProduct ensembl:ENSBTAG00000021045 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112242
TP53 GeneProduct ensembl:ENSBTAG00000001069 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141510
CDC42 GeneProduct ensembl:ENSBTAG00000001700 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000070831
CDK6 GeneProduct ensembl:ENSBTAG00000044023 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105810
MYC GeneProduct ensembl:ENSBTAG00000008409 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136997
PIK3R1 Protein ensembl:ENSBTAG00000010989 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P27986

References

  1. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Park SY, Lee JH, Ha M, Nam JW, Kim VN. Nat Struct Mol Biol. 2009 Jan;16(1):23–9. PubMed Europe PMC Scholia
  2. The miR-34 family in cancer and apoptosis. Hermeking H. Cell Death Differ. 2010 Feb;17(2):193–9. PubMed Europe PMC Scholia
  3. p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. Christoffersen NR, Shalgi R, Frankel LB, Leucci E, Lees M, Klausen M, et al. Cell Death Differ. 2010 Feb;17(2):236–45. PubMed Europe PMC Scholia
  4. Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, et al. Cell. 2010 Apr 2;141(1):129–41. PubMed Europe PMC Scholia