Sphingolipid metabolism (WP3232)

Bos taurus

The sphingolipid metabolites and genes (with the gene abbreviations shown in boxes, or enzyme names where gene names are ambiguous) are given for the condensation of serine and palmitoyl-CoA to form 3-ketosphinganine (3-ketoSa) by serine palmitoyltransferase, which is reduced to sphinganine (Sa), acylated to dihydroceramides, DHCer, by (DH)Cer synthases, and incorporated into more complex DH-sphingolipids (the 1-phosphate, DHCerP, sphingomyelins, DHSM, glucosylceramides, DHGlcCer, galactosylceramides, DHGalCer, lactosylceramides, DHLacCer, and sulfatides, or desaturated to Cer followed by headgroup addition. Also included are a number of the catabolic genes, e.g., sphingomyelinases, SMases, ceramidases, ASAH, sphingosine kinases, for the formation of sphinganine 1-phosphate (Sa1P) and sphingosine 1-phosphate (So1P), and phosphatases for the reverse reaction and the lyase that cleaves sphingoid base 1-phosphates to ethanolamine phosphate (EP), hexadecanal (C16:0al) and hexadecenal (C16:1al).

Authors

Martina Summer-Kutmon and Eric Weitz

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

sphingolipid metabolic pathway

Participants

Label Type Compact URI Comment
Palmityl-CoA Metabolite hmdb:HMDB0001338
Sphinganine Metabolite hmdb:HMDB0000269
Sphingosine Metabolite hmdb:HMDB0000252
Dihydroceramide Metabolite hmdb:HMDB0006752
Ceramides Metabolite hmdb:HMDB0004949
Ethanolamine phosphate Metabolite chebi:17553
Sa 1-phosphate Metabolite hmdb:HMDB0001383
Serine Metabolite hmdb:HMDB0000187
Sphingosine 1-phosphate Metabolite hmdb:HMDB0000277
GalCer Metabolite hmdb:HMDB0000140
Sphingomyelin Metabolite hmdb:HMDB0001348
GlcCer Metabolite hmdb:HMDB0000140
Lactosylceramide Metabolite hmdb:HMDB0006750
Sulfatide Metabolite hmdb:HMDB0000024
SERINC1 GeneProduct ensembl:ENSBTAG00000000019 2.3.1.24
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57515
ASAH2 GeneProduct ensembl:ENSBTAG00000003529 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:56624
CERS6 GeneProduct ensembl:ENSBTAG00000044179 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:253782
SGPP2 GeneProduct ensembl:ENSBTAG00000046649 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:130367
LASS5 GeneProduct ensembl:ENSBTAG00000017395 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:91012
CERS4 GeneProduct ensembl:ENSBTAG00000003434 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:79603
SPTLC2 GeneProduct ensembl:ENSBTAG00000020480 2.3.1.50
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9517
GAL3ST1 GeneProduct ensembl:ENSBTAG00000014232 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9514
KDSR GeneProduct ensembl:ENSBTAG00000007723 1.1.1.102
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2531
SPTLC3 GeneProduct ensembl:ENSBTAG00000014252 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55304
B4GALT6 GeneProduct ensembl:ENSBTAG00000044063 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9331
ASAH1 GeneProduct ensembl:ENSBTAG00000011257 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:427
CERK GeneProduct ensembl:ENSBTAG00000046654 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64781
SPHK2 GeneProduct ensembl:ENSBTAG00000009872 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:56848
LASS3 GeneProduct ensembl:ENSBTAG00000006987 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:204219
PPAP2A GeneProduct ensembl:ENSBTAG00000010526 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8611
CERS2 GeneProduct ensembl:ENSBTAG00000000099 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:29956
SPHK1 GeneProduct ensembl:ENSBTAG00000008507 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8877
SPTLC1 GeneProduct ensembl:ENSBTAG00000002220 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10558
CERK GeneProduct ensembl:ENSBTAG00000046654 2.7.1.138
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64781
SGMS1 Protein ensembl:ENSBTAG00000011748 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q86VZ5
SGMS2 Protein ensembl:ENSBTAG00000016805 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q8NHU3
SGMS2 Protein ensembl:ENSBTAG00000016805 2.7.8.3
HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q8NHU3
SGMS1 Protein ensembl:ENSBTAG00000011748 2.7.8.3
HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q86VZ5

References

  1. (Glyco)sphingolipidology: an amazing challenge and opportunity for systems biology. Merrill AH Jr, Wang MD, Park M, Sullards MC. Trends Biochem Sci. 2007 Oct;32(10):457–68. PubMed Europe PMC Scholia
  2. Sphingolipidomics: a valuable tool for understanding the roles of sphingolipids in biology and disease. Merrill AH Jr, Stokes TH, Momin A, Park H, Portz BJ, Kelly S, et al. J Lipid Res. 2009 Apr;50 Suppl(Suppl):S97-102. PubMed Europe PMC Scholia