Ectoderm differentiation (WP3208)

Bos taurus

Model depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lines, following differentiation to multiple lineages (ectoderm, mesoderm, endoderm, embryoid body). The underlying genomic data can be obtained from: https://www.synapse.org/#!Synapse:syn1773109

Authors

Martina Summer-Kutmon , Susan Coort , and Eric Weitz

Activity

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

regulatory pathway

Participants

Label Type Compact URI Comment
GRAMD1B GeneProduct ensembl:ENSBTAG00000001410 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000023171
NLK GeneProduct ensembl:ENSBTAG00000014825 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087095
ZFHX4 GeneProduct ensembl:ENSBTAG00000033268 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091656
KCNK10 GeneProduct ensembl:ENSBTAG00000019355 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100433
TOX3 GeneProduct ensembl:ENSBTAG00000000418 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103460
ELOVL4 GeneProduct ensembl:ENSBTAG00000015498 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118402
NARS2 GeneProduct ensembl:ENSBTAG00000039943 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137513
ASTN1 GeneProduct ensembl:ENSBTAG00000012953 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152092
GLB1 GeneProduct ensembl:ENSBTAG00000015254 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170266
CLVS1 GeneProduct ensembl:ENSBTAG00000043978 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000177182
RGMA GeneProduct ensembl:ENSBTAG00000018603 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182175
DMD GeneProduct ensembl:ENSBTAG00000008248 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198947
PI4KA GeneProduct ensembl:ENSBTAG00000013971 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000241973
PRKAG2 GeneProduct ensembl:ENSBTAG00000002917 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106617
CAP2 GeneProduct ensembl:ENSBTAG00000016924 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112186
STX16 GeneProduct ensembl:ENSBTAG00000003872 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124222
BCAS3 GeneProduct ensembl:ENSBTAG00000002663 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141376
CELSR2 GeneProduct ensembl:ENSBTAG00000018804 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143126
RHPN1 GeneProduct ensembl:ENSBTAG00000002104 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000158106
GREB1 GeneProduct ensembl:ENSBTAG00000015402 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196208
ARHGDIG GeneProduct ensembl:ENSBTAG00000027854 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000242173
CLDN11 GeneProduct ensembl:ENSBTAG00000019060 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000013297
EDA GeneProduct ensembl:ENSBTAG00000012543 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000158813
FZD5 GeneProduct ensembl:ENSBTAG00000020957 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163251
FZD8 GeneProduct ensembl:ENSBTAG00000015072 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000177283
GATA6 GeneProduct ensembl:ENSBTAG00000005734 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141448
JAKMIP1 GeneProduct ensembl:ENSBTAG00000011170 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152969
PLXNA2 GeneProduct ensembl:ENSBTAG00000001173 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000076356
PPFIBP2 GeneProduct ensembl:ENSBTAG00000016140 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166387
SOCS2 GeneProduct ensembl:ENSBTAG00000012007 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120833
SPRY2 GeneProduct ensembl:ENSBTAG00000001774 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136158
STC1 GeneProduct ensembl:ENSBTAG00000001687 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159167
TRPM2 GeneProduct ensembl:ENSBTAG00000021901 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142185
ABCC4 GeneProduct ensembl:ENSBTAG00000046611 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125257
AES GeneProduct ensembl:ENSBTAG00000031363 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104964
ANKS1B GeneProduct ensembl:ENSBTAG00000013979 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185046
ARHGDIG GeneProduct ensembl:ENSBTAG00000027854 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000242173
C1GALT1 GeneProduct ensembl:ENSBTAG00000004995 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106392
CCL2 GeneProduct ensembl:ENSBTAG00000037811 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108691
ELOVL2 GeneProduct ensembl:ENSBTAG00000002497 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197977
FZD4 GeneProduct ensembl:ENSBTAG00000040128 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174804
GAS2L1 GeneProduct ensembl:ENSBTAG00000012504 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185340
KIFC3 GeneProduct ensembl:ENSBTAG00000007181 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140859
LY6E GeneProduct ensembl:ENSBTAG00000017040 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160932
NFATC1 GeneProduct ensembl:ENSBTAG00000000656 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131196
PGM1 GeneProduct ensembl:ENSBTAG00000019011 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079739
PLCXD3 GeneProduct ensembl:ENSBTAG00000010822 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182836
PODXL GeneProduct ensembl:ENSBTAG00000010452 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000128567
POU2F2 GeneProduct ensembl:ENSBTAG00000008556 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000028277
PTPRB GeneProduct ensembl:ENSBTAG00000015296 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127329
ROR2 GeneProduct ensembl:ENSBTAG00000005092 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169071
RRBP1 GeneProduct ensembl:ENSBTAG00000015438 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125844
SERPINB6 GeneProduct ensembl:ENSBTAG00000025280 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124570
SORCS1 GeneProduct ensembl:ENSBTAG00000007948 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108018
ST8SIA4 GeneProduct ensembl:ENSBTAG00000021445 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113532
TNFRSF11B GeneProduct ensembl:ENSBTAG00000007423 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164761
TSKU GeneProduct ensembl:ENSBTAG00000001537 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182704
WDR44 GeneProduct ensembl:ENSBTAG00000018697 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131725
bta-mir-34c GeneProduct ensembl:ENSBTAG00000029991 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207562
PHF8 GeneProduct ensembl:ENSBTAG00000013289 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172943
MECP2 GeneProduct ensembl:ENSBTAG00000047855 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169057
ZNF219 GeneProduct ensembl:ENSBTAG00000021008 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165804
MZF1 GeneProduct ensembl:ENSBTAG00000037581 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099326
bta-mir-361 GeneProduct ensembl:ENSBTAG00000029810 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000199051
bta-mir-15b GeneProduct ensembl:ENSBTAG00000029929 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207779
BAZ1A GeneProduct ensembl:ENSBTAG00000020164 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11177
SKIL GeneProduct ensembl:ENSBTAG00000004154 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6498
ZBTB2 GeneProduct ensembl:ENSBTAG00000014790 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57621
PIM1 GeneProduct ensembl:ENSBTAG00000000396 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5292
MYC GeneProduct ensembl:ENSBTAG00000008409 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
ZBTB2 GeneProduct ensembl:ENSBTAG00000014790 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57621
LDB2 GeneProduct ensembl:ENSBTAG00000014058 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9079
UBF GeneProduct ensembl:ENSBTAG00000005067 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7343
MYC GeneProduct ensembl:ENSBTAG00000008409 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4609
ZBTB2 GeneProduct ensembl:ENSBTAG00000014790 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57621
TRIM33 GeneProduct ensembl:ENSBTAG00000001499 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197323
SMAD4 GeneProduct ensembl:ENSBTAG00000006919 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141646
FOXL1 GeneProduct ensembl:ENSBTAG00000040605 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000176678
TCF7L1 GeneProduct ensembl:ENSBTAG00000010111 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152284
HESX1 GeneProduct ensembl:ENSBTAG00000001439 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163666
SIX6 GeneProduct ensembl:ENSBTAG00000013035 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184302
MAFB GeneProduct ensembl:ENSBTAG00000003396 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204103
TFAP2C GeneProduct ensembl:ENSBTAG00000002065 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087510
SOX2 GeneProduct ensembl:ENSBTAG00000011598 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181449
TFAP2A GeneProduct ensembl:ENSBTAG00000001250 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137203
ZBTB2 GeneProduct ensembl:ENSBTAG00000014790 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:57621
FHL2 GeneProduct ensembl:ENSBTAG00000001086 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2274
SKIL GeneProduct ensembl:ENSBTAG00000004154 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6498
BCOR GeneProduct ensembl:ENSBTAG00000047339 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:54880

References

  1. Expression of avian C-terminal binding proteins (Ctbp1 and Ctbp2) during embryonic development. Van Hateren N, Shenton T, Borycki AG. Dev Dyn. 2006 Feb;235(2):490–5. PubMed Europe PMC Scholia
  2. Smurf1 regulates neural patterning and folding in Xenopus embryos by antagonizing the BMP/Smad1 pathway. Alexandrova EM, Thomsen GH. Dev Biol. 2006 Nov 15;299(2):398–410. PubMed Europe PMC Scholia
  3. Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis. Smith AN, Miller LA, Radice G, Ashery-Padan R, Lang RA. Development. 2009 Sep;136(17):2977–85. PubMed Europe PMC Scholia
  4. Chemical genetics identifies c-Src as an activator of primitive ectoderm formation in murine embryonic stem cells. Meyn MA 3rd, Smithgall TE. Sci Signal. 2009 Oct 13;2(92):ra64. PubMed Europe PMC Scholia
  5. HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain. Andoniadou CL, Signore M, Young RM, Gaston-Massuet C, Wilson SW, Fuchs E, et al. Development. 2011 Nov;138(22):4931–42. PubMed Europe PMC Scholia
  6. Beyond cell adhesion: the role of armadillo proteins in the heart. Swope D, Li J, Radice GL. Cell Signal. 2013 Jan;25(1):93–100. PubMed Europe PMC Scholia
  7. Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development. Mukhopadhyay A, Krishnaswami SR, Cowing-Zitron C, Hung NJ, Reilly-Rhoten H, Burns J, et al. Dev Biol. 2013 Jan 15;373(2):373–82. PubMed Europe PMC Scholia
  8. Differential BMP signaling controls formation and differentiation of multipotent preplacodal ectoderm progenitors from human embryonic stem cells. Leung AW, Kent Morest D, Li JYH. Dev Biol. 2013 Jul 15;379(2):208–20. PubMed Europe PMC Scholia
  9. Hedgehog and Gli signaling in embryonic mammary gland development. Lee MY, Sun L, Veltmaat JM. J Mammary Gland Biol Neoplasia. 2013 Jun;18(2):133–8. PubMed Europe PMC Scholia