NRF2 pathway (WP3190)
Bos taurus
NRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins.
Authors
Martina Summer-Kutmon and Elisa CirilloActivity
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Cited In
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Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
regulatory pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Ligand | Metabolite | chebi:48705 | |
| SLC2A1 | GeneProduct | ensembl:ENSBTAG00000009617 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117394 |
| CES3 | GeneProduct | ensembl:ENSBTAG00000040413 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172828 |
| ME1 | GeneProduct | ensembl:ENSBTAG00000005681 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000065833 |
| PRDX1 | GeneProduct | ensembl:ENSBTAG00000003642 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117450 |
| GSTA2 | GeneProduct | ensembl:ENSBTAG00000006546 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000243955 |
| SLC2A11 | GeneProduct | ensembl:ENSBTAG00000018647 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000133460 |
| GPX2 | GeneProduct | ensembl:ENSBTAG00000048112 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000176153 |
| HGF | GeneProduct | ensembl:ENSBTAG00000017664 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000019991 |
| UGT1A4 | GeneProduct | ensembl:ENSBTAG00000048275 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000244474 |
| FGF13 | GeneProduct | ensembl:ENSBTAG00000020194 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000129682 |
| BLVRB | GeneProduct | ensembl:ENSBTAG00000010508 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000090013 |
| GCLC | GeneProduct | ensembl:ENSBTAG00000015571 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000001084 |
| MGST3 | GeneProduct | ensembl:ENSBTAG00000010265 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143198 |
| SLC7A11 | GeneProduct | ensembl:ENSBTAG00000034075 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151012 |
| NFE2L2 | GeneProduct | ensembl:ENSBTAG00000019255 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116044 |
| GSTA2 | GeneProduct | ensembl:ENSBTAG00000006546 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174156 |
| SLC2A13 | GeneProduct | ensembl:ENSBTAG00000043962 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151229 |
| TXN | GeneProduct | ensembl:ENSBTAG00000002953 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136810 |
| ABCC4 | GeneProduct | ensembl:ENSBTAG00000046611 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125257 |
| ECSOD | GeneProduct | ensembl:ENSBTAG00000013980 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109610 |
| SLC2A9 | GeneProduct | ensembl:ENSBTAG00000039197 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109667 |
| GPX3 | GeneProduct | ensembl:ENSBTAG00000043553 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000211445 |
| ADH7 | GeneProduct | ensembl:ENSBTAG00000015729 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196344 |
| EPHA3 | GeneProduct | ensembl:ENSBTAG00000006811 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000044524 |
| GSR | GeneProduct | ensembl:ENSBTAG00000007115 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104687 |
| HSP90AB1 | GeneProduct | ensembl:ENSBTAG00000047699 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000096384 |
| SLC2A3 | GeneProduct | ensembl:ENSBTAG00000004556 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000173262 |
| PGD | GeneProduct | ensembl:ENSBTAG00000013527 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142657 |
| ALDH3A1 | GeneProduct | ensembl:ENSBTAG00000021113 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108602 |
| CYP2A6 | GeneProduct | ensembl:ENSBTAG00000047815 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000255974 |
| PPARD | GeneProduct | ensembl:ENSBTAG00000017542 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112033 |
| CBR3 | GeneProduct | ensembl:ENSBTAG00000018688 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159231 |
| TGFB1 | GeneProduct | ensembl:ENSBTAG00000020457 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105329 |
| G6PD | GeneProduct | ensembl:ENSBTAG00000019512 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160211 |
| TXNRD1 | GeneProduct | ensembl:ENSBTAG00000013912 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198431 |
| TGFB2 | GeneProduct | ensembl:ENSBTAG00000005359 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000092969 |
| GSTP1 | GeneProduct | ensembl:ENSBTAG00000003548 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000084207 |
| CES5A | GeneProduct | ensembl:ENSBTAG00000011164 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159398 |
| PTGR1 | GeneProduct | ensembl:ENSBTAG00000011027 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106853 |
| GSTA2 | GeneProduct | ensembl:ENSBTAG00000006546 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182793 |
| UGT1A1 | GeneProduct | ensembl:ENSBTAG00000026181 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000241635 |
| PRDX6 | GeneProduct | ensembl:ENSBTAG00000004855 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117592 |
| HSP90AA1 | GeneProduct | ensembl:ENSBTAG00000006270 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000080824 |
| GGT1 | GeneProduct | ensembl:ENSBTAG00000046900 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100031 |
| GSTA4 | GeneProduct | ensembl:ENSBTAG00000004288 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170899 |
| NQO1 | GeneProduct | ensembl:ENSBTAG00000020632 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181019 |
| DNAJB1 | GeneProduct | ensembl:ENSBTAG00000045858 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132002 |
| CES1 | GeneProduct | ensembl:ENSBTAG00000011021 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198848 |
| CES4A | GeneProduct | ensembl:ENSBTAG00000038325 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172824 |
| TGFA | GeneProduct | ensembl:ENSBTAG00000000783 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163235 |
| GSTT1 | GeneProduct | ensembl:ENSBTAG00000040298 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099984 |
| UGT2B7 | GeneProduct | ensembl:ENSBTAG00000040337 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171234 |
| SLC2A10 | GeneProduct | ensembl:ENSBTAG00000002942 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197496 |
| SLC2A12 | GeneProduct | ensembl:ENSBTAG00000019002 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000146411 |
| GSTA2 | GeneProduct | ensembl:ENSBTAG00000006546 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000244067 |
| GCLM | GeneProduct | ensembl:ENSBTAG00000007842 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000023909 |
| ABCC5 | GeneProduct | ensembl:ENSBTAG00000017666 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000114770 |
| MAFF | GeneProduct | ensembl:ENSBTAG00000021435 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185022 |
| GGFBPP5 | GeneProduct | ensembl:ENSBTAG00000004150 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157168 |
| SLC2A5 | GeneProduct | ensembl:ENSBTAG00000007302 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142583 |
| MGST2 | GeneProduct | ensembl:ENSBTAG00000021779 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000085871 |
| SERPINA1 | GeneProduct | ensembl:ENSBTAG00000018843 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197249 |
| SQSTM1 | GeneProduct | ensembl:ENSBTAG00000015591 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000161011 |
| EGR1 | GeneProduct | ensembl:ENSBTAG00000010069 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120738 |
| CES2 | GeneProduct | ensembl:ENSBTAG00000005093 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172831 |
| SLC2A4 | GeneProduct | ensembl:ENSBTAG00000009190 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181856 |
| SLC2A2 | GeneProduct | ensembl:ENSBTAG00000005386 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163581 |
| UGT1A3 | GeneProduct | ensembl:ENSBTAG00000048275 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000243135 |
| SLC2A6 | GeneProduct | ensembl:ENSBTAG00000001824 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160326 |
| SLC2A8 | GeneProduct | ensembl:ENSBTAG00000006957 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136856 |
| FTL | GeneProduct | ensembl:ENSBTAG00000019709 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087086 |
| EPHA2 | GeneProduct | ensembl:ENSBTAG00000000815 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142627 |
| HMOX1 | GeneProduct | ensembl:ENSBTAG00000015582 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100292 |
| MAFG | GeneProduct | ensembl:ENSBTAG00000000040 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197063 |
| HBEGF | GeneProduct | ensembl:ENSBTAG00000021766 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113070 |
| HSPA1A | GeneProduct | ensembl:ENSBTAG00000025441 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204389 |
| KEAP1 | GeneProduct | ensembl:ENSBTAG00000003543 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079999 |
| TGFBR2 | GeneProduct | ensembl:ENSBTAG00000019832 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163513 |
| SLC2A3 | GeneProduct | ensembl:ENSBTAG00000004556 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000059804 |
| PDGFB | GeneProduct | ensembl:ENSBTAG00000021697 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100311 |
| AGER | GeneProduct | ensembl:ENSBTAG00000014420 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204305 |
| CYP4A11 | GeneProduct | ensembl:ENSBTAG00000000229 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187048 |
| RXRA | GeneProduct | ensembl:ENSBTAG00000017851 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186350 |
| GSTM3 | GeneProduct | ensembl:ENSBTAG00000001842 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134202 |
| GSTM1 | GeneProduct | ensembl:ENSBTAG00000031788 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168765 |
| SLC5A2 | GeneProduct | ensembl:ENSBTAG00000010096 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140675 |
| SGLT1 | GeneProduct | ensembl:ENSBTAG00000012851 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100170 |
| SLC5A4 | GeneProduct | ensembl:ENSBTAG00000008117 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100191 |
| SLC5A10 | GeneProduct | ensembl:ENSBTAG00000003700 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154025 |
| SLC5A9 | GeneProduct | ensembl:ENSBTAG00000014225 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117834 |
| SLC5A6 | GeneProduct | ensembl:ENSBTAG00000006832 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138074 |
| SLC5A11 | GeneProduct | ensembl:ENSBTAG00000003467 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000158865 |
| SLC5A12 | GeneProduct | ensembl:ENSBTAG00000021858 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148942 |
| SLC5A7 | GeneProduct | ensembl:ENSBTAG00000004352 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115665 |
| SMCT1 | GeneProduct | ensembl:ENSBTAG00000011525 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000256870 |
| SLC5A5 | GeneProduct | ensembl:ENSBTAG00000015830 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105641 |
| SLC6A2 | GeneProduct | ensembl:ENSBTAG00000003353 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103546 |
| SLC6A1 | GeneProduct | ensembl:ENSBTAG00000005857 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157103 |
| SLC6A4 | GeneProduct | ensembl:ENSBTAG00000019349 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108576 |
| SLC6A11 | GeneProduct | ensembl:ENSBTAG00000038962 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132164 |
| SLC6A9 | GeneProduct | ensembl:ENSBTAG00000006043 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196517 |
| SLC6A6 | GeneProduct | ensembl:ENSBTAG00000011088 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131389 |
| SLC6A13 | GeneProduct | ensembl:ENSBTAG00000014525 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000010379 |
| SLC6A3 | GeneProduct | ensembl:ENSBTAG00000015843 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142319 |
| SLC6A7 | GeneProduct | ensembl:ENSBTAG00000000910 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000011083 |
| SLC6A8 | GeneProduct | ensembl:ENSBTAG00000009959 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130821 |
| SLC6A5 | GeneProduct | ensembl:ENSBTAG00000014300 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165970 |
| SLC6A16 | GeneProduct | ensembl:ENSBTAG00000030543 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000063127 |
| SLC6A15 | GeneProduct | ensembl:ENSBTAG00000018432 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000072041 |
| SLC6A18 | GeneProduct | ensembl:ENSBTAG00000012559 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164363 |
| SLC6A20 | GeneProduct | ensembl:ENSBTAG00000031340 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163817 |
| SLC6A17 | GeneProduct | ensembl:ENSBTAG00000001981 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197106 |
| SLC6A19 | GeneProduct | ensembl:ENSBTAG00000045695 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174358 |
| SLC39A2 | GeneProduct | ensembl:ENSBTAG00000000936 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165794 |
| SLC39A1 | GeneProduct | ensembl:ENSBTAG00000011284 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143570 |
| SLC39A4 | GeneProduct | ensembl:ENSBTAG00000046026 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000147804 |
| SLC39A10 | GeneProduct | ensembl:ENSBTAG00000016782 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196950 |
| SLC39A9 | GeneProduct | ensembl:ENSBTAG00000017811 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000029364 |
| SLC39A6 | GeneProduct | ensembl:ENSBTAG00000000998 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141424 |
| SLC39A11 | GeneProduct | ensembl:ENSBTAG00000018837 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000133195 |
| SLC39A12 | GeneProduct | ensembl:ENSBTAG00000015525 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148482 |
| SLC39A3 | GeneProduct | ensembl:ENSBTAG00000017706 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141873 |
| SLC39A7 | GeneProduct | ensembl:ENSBTAG00000008191 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112473 |
| SLC39A8 | GeneProduct | ensembl:ENSBTAG00000005668 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138821 |
| SLC39A5 | GeneProduct | ensembl:ENSBTAG00000002799 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139540 |
| SLC39A13 | GeneProduct | ensembl:ENSBTAG00000019436 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165915 |
| SLC39A14 | GeneProduct | ensembl:ENSBTAG00000019225 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104635 |
References
- The GI-GPx gene is a target for Nrf2. Banning A, Deubel S, Kluth D, Zhou Z, Brigelius-Flohé R. Mol Cell Biol. 2005 Jun;25(12):4914–23. PubMed Europe PMC Scholia
- NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Hayes JD, McMahon M. Trends Biochem Sci. 2009 Apr;34(4):176–88. PubMed Europe PMC Scholia
- Nrf2 target genes are induced under marginal selenium-deficiency. Müller M, Banning A, Brigelius-Flohé R, Kipp A. Genes Nutr. 2010 Dec;5(4):297–307. PubMed Europe PMC Scholia
- From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans. Bock KW. Biochem Pharmacol. 2011 Jul 1;82(1):9–16. PubMed Europe PMC Scholia
- Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Fijten RRR, Jennen DGJ, van Delft JHM. Curr Drug Metab. 2013 Dec;14(10):1022–8. PubMed Europe PMC Scholia