Felbamate metabolism (WP3189)

Bos taurus

CYP metabolism of felbamate.

Authors

Martina Summer-Kutmon and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

nervous system drug pathway

Participants

Label Type Compact URI Comment
atropaldehyde Metabolite pubchem.compound:10312
3-Hydroxy-2-phenylpropylcarbamate Metabolite chemspider:184751
3-carbamoyl-2-phenylpropionic acid Metabolite pubchem.compound:3025746
3-carbamoyl-2-phenylpropionaldehyde Metabolite pubchem.compound:21350391
p-hydroxyfelbamate Metabolite chemspider:8096945
Felbamate Metabolite hmdb:HMDB0015084
2-hydroxyfelbamate Metabolite chemspider:8575477
CYP3A4 GeneProduct ensembl:ENSBTAG00000047379 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160868
CYP2E1 GeneProduct ensembl:ENSBTAG00000018365 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130649

References

  1. Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation. Glue P, Banfield CR, Perhach JL, Mather GG, Racha JK, Levy RH. Clin Pharmacokinet. 1997 Sep;33(3):214–24. PubMed Europe PMC Scholia
  2. Felbamate-induced apoptosis of hematopoietic cells is mediated by redox-sensitive and redox-independent pathways. Husain Z, Pinto C, Sofia RD, Yunis EJ. Epilepsy Res. 2002 Jan;48(1–2):57–69. PubMed Europe PMC Scholia