Angiogenesis (WP3184)

Bos taurus

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This pathway is a concise and simplified version of the basic proteins involved in angiogenesis. The proces is regulated by hyopoxia, which results in the transcription of eg. VEGF1, FGF2, PDGFbeta, MMP9, MMP2 and Ang1. These proteins bind to their receptors and by doing this they initiate different pathways that result in vessel formation.

Authors

Martina Summer-Kutmon and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

signaling pathway pertinent to development

Participants

Label Type Compact URI Comment
MAPK1 GeneProduct ensembl:ENSBTAG00000010312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100030
ARNT GeneProduct ensembl:ENSBTAG00000021037 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:405
PIK3CA GeneProduct ensembl:ENSBTAG00000009232 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290
TEK GeneProduct ensembl:ENSBTAG00000020148 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7010
NOS3 GeneProduct ensembl:ENSBTAG00000017680 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164867
ANGPT1 GeneProduct ensembl:ENSBTAG00000014051 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q15389
SMAD1 GeneProduct ensembl:ENSBTAG00000002835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170365
PLCG1 GeneProduct ensembl:ENSBTAG00000017584 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124181
MMP9 GeneProduct ensembl:ENSBTAG00000020676 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100985
FGF2 GeneProduct ensembl:ENSBTAG00000005691 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685
CREBBP GeneProduct ensembl:ENSBTAG00000026403 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1387
PDGFB GeneProduct ensembl:ENSBTAG00000021697 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100311
MAPK14 GeneProduct ensembl:ENSBTAG00000020783 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
PTK2 GeneProduct ensembl:ENSBTAG00000009578 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q05397
PDGFRA GeneProduct ensembl:ENSBTAG00000007173 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P16234
VEGFA GeneProduct ensembl:ENSBTAG00000047561 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P15692
HIF1A GeneProduct ensembl:ENSBTAG00000020935 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3091
TIMP2 GeneProduct ensembl:ENSBTAG00000010899 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000035862
SRC GeneProduct ensembl:ENSBTAG00000008938 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197122
FLT1 GeneProduct ensembl:ENSBTAG00000016915 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102755
KDR GeneProduct ensembl:ENSBTAG00000000782 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3791
FGFR2 GeneProduct ensembl:ENSBTAG00000014064 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2263
AKT1 GeneProduct ensembl:ENSBTAG00000017636 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142208
TIMP3 Protein ensembl:ENSBTAG00000020638 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100234

References

  1. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Millauer B, Wizigmann-Voos S, Schnürch H, Martinez R, Møller NP, Risau W, et al. Cell. 1993 Mar 26;72(6):835–46. PubMed Europe PMC Scholia
  2. Angiopoietin-1 induces sprouting angiogenesis in vitro. Koblizek TI, Weiss C, Yancopoulos GD, Deutsch U, Risau W. Curr Biol. 1998 Apr 23;8(9):529–32. PubMed Europe PMC Scholia
  3. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, et al. Nat Cell Biol. 2000 Oct;2(10):737–44. PubMed Europe PMC Scholia
  4. Vascular endothelial growth factor and basic fibroblast growth factor differentially modulate early postnatal coronary angiogenesis. Tomanek RJ, Sandra A, Zheng W, Brock T, Bjercke RJ, Holifield JS. Circ Res. 2001 Jun 8;88(11):1135–41. PubMed Europe PMC Scholia
  5. Angiogenesis of the heart. Kutryk MJB, Stewart DJ. Microsc Res Tech. 2003 Feb 1;60(2):138–58. PubMed Europe PMC Scholia
  6. The role of the matrix metalloproteinases during in vitro vessel formation. Burbridge MF, Cogé F, Galizzi JP, Boutin JA, West DC, Tucker GC. Angiogenesis. 2002;5(3):215–26. PubMed Europe PMC Scholia
  7. Growth factor activation in myocardial vascularization: therapeutic implications. Tomanek RJ, Zheng W, Yue X. Mol Cell Biochem. 2004 Sep;264(1–2):3–11. PubMed Europe PMC Scholia
  8. Therapeutic angiogenesis and vasculogenesis for tissue regeneration. Madeddu P. Exp Physiol. 2005 May;90(3):315–26. PubMed Europe PMC Scholia
  9. The matrix revolutions: matrix metalloproteinase, vasculogenesis, and ischemic tissue repair. Renault MA, Losordo DW. Circ Res. 2007 Mar 30;100(6):749–50. PubMed Europe PMC Scholia
  10. Angiopoietin-1 in the treatment of ischemia and sepsis. Novotny NM, Lahm T, Markel TA, Crisostomo PR, Wang M, Wang Y, et al. Shock. 2009 Apr;31(4):335–41. PubMed Europe PMC Scholia
  11. PDGF and vessel maturation. Hellberg C, Ostman A, Heldin CH. Recent Results Cancer Res. 2010;180:103–14. PubMed Europe PMC Scholia
  12. Synergistic effects of FGF-2 and PDGF-BB on angiogenesis and muscle regeneration in rabbit hindlimb ischemia model. Li J, Wei Y, Liu K, Yuan C, Tang Y, Quan Q, et al. Microvasc Res. 2010 Jul;80(1):10–7. PubMed Europe PMC Scholia