Effects of nitric oxide (WP3182)

Bos taurus

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NO (Nitric oxide) is an important signalling molecule with vasodilatory and anti-inflammatory effects, indicating a postive role in reducing hypertension and cardiovascular disease. At the same time, NO is also associated with health risks such as increased risk in carcinogenesis, and hypoxia in infants. It has been suggested that NO can also increase mitochondrial efficiency. NO can be formed from L-Arginine through the classic Arginine-NO-Synthase pathway, or it can be formed directly from dietary nitrite by deoxiginated globins.

Authors

Martina Summer-Kutmon and Eric Weitz

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

cardiovascular system homeostasis pathway

Participants

Label Type Compact URI Comment
Nitric oxide Metabolite hmdb:HMDB0003378
Nitrate Metabolite hmdb:HMDB0002878
Citrulline Metabolite hmdb:HMDB0000904
VItamin C Metabolite hmdb:HMDB0000044
Nitrite Metabolite hmdb:HMDB0002786
L-Arginine Metabolite hmdb:HMDB0000517
Oxygen Metabolite hmdb:HMDB0001377
NOS3 GeneProduct ensembl:ENSBTAG00000017680 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4846
HBA GeneProduct ensembl:ENSBTAG00000026417 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000206172
MB GeneProduct ensembl:ENSBTAG00000005333 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4151
NOS1 GeneProduct ensembl:ENSBTAG00000002023 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4842
COX1 GeneProduct ensembl:ENSBTAG00000043561 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4512
INOS GeneProduct ensembl:ENSBTAG00000006894 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4843
XDH GeneProduct ensembl:ENSBTAG00000012519 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000158125
AOX1 Protein ensembl:ENSBTAG00000009725 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138356

References

  1. Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Hord NG, Tang Y, Bryan NS. Am J Clin Nutr. 2009 Jul;90(1):1–10. PubMed Europe PMC Scholia
  2. Nitrate and nitrite in biology, nutrition and therapeutics. Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, et al. Nat Chem Biol. 2009 Dec;5(12):865–9. PubMed Europe PMC Scholia
  3. Dietary inorganic nitrate improves mitochondrial efficiency in humans. Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, et al. Cell Metab. 2011 Feb 2;13(2):149–59. PubMed Europe PMC Scholia