Interleukin-1 (IL-1) structural pathway (WP3178)

Bos taurus

Pathway published in http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1003470 IL-1 signaling pathway reconstructed by combining related pathways and information from the literature. This detailed map of IL-1 signaling presents the protein-protein interactions and the resulting cellular events. The colored nodes represent proteins having experimentally identified 3D structures and the white nodes are the proteins without 3D structures. The edges represent protein-protein interactions (straight/dashed arrows relate to available/unavailable 3D structures of proteins) or associations leading to cellular events such as cell cycle or gene expression (dashed arrows beginning with circular heads). doi:10.1371/journal.pcbi.1003470.g002

Authors

Martina Summer-Kutmon , Marianthi Kalafati , and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

signaling pathway interleukin-1 signaling pathway

Participants

Label Type Compact URI Comment
IL1A GeneProduct ensembl:ENSBTAG00000010349 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115008
IL1R1 GeneProduct ensembl:ENSBTAG00000005273 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115594
IRAK1 GeneProduct ensembl:ENSBTAG00000016085 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184216
IRAK2 GeneProduct ensembl:ENSBTAG00000006193 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134070
MYD88 GeneProduct ensembl:ENSBTAG00000000563 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172936
IRAK4 GeneProduct ensembl:ENSBTAG00000021105 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198001
TOLLIP GeneProduct ensembl:ENSBTAG00000008237 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000078902
TRAF6 GeneProduct ensembl:ENSBTAG00000036009 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175104
IRF7 GeneProduct ensembl:ENSBTAG00000047680 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185507
MAP3K1 GeneProduct ensembl:ENSBTAG00000013790 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000095015
MAP3K7IP1 GeneProduct ensembl:ENSBTAG00000019828 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100324
MAP3K7 GeneProduct ensembl:ENSBTAG00000002625 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135341
NFKB1 GeneProduct ensembl:ENSBTAG00000020270 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P19838
MAP2K3 GeneProduct ensembl:ENSBTAG00000010576 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000034152
MAP3K14 GeneProduct ensembl:ENSBTAG00000007084 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000006062
CHUK GeneProduct ensembl:ENSBTAG00000007591 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000213341
MAPK11 GeneProduct ensembl:ENSBTAG00000030182 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185386
MAPK8 GeneProduct ensembl:ENSBTAG00000007876 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P45983
MAPK3 GeneProduct ensembl:ENSBTAG00000016156 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102882
BIKBA GeneProduct ensembl:ENSBTAG00000016683 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P25963
MAP3K8 GeneProduct ensembl:ENSBTAG00000011600 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107968
MAPKAPK2 GeneProduct ensembl:ENSBTAG00000038107 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000162889
RPS6KA5 GeneProduct ensembl:ENSBTAG00000010906 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100784
ELK1 GeneProduct ensembl:ENSBTAG00000015817 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000126767
MBP GeneProduct ensembl:ENSBTAG00000022890 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197971
HSP27 GeneProduct ensembl:ENSBTAG00000035584 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160633
RELA GeneProduct ensembl:ENSBTAG00000013895 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000173039
IL1RAP GeneProduct ensembl:ENSBTAG00000013205 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196083
TAB2 GeneProduct ensembl:ENSBTAG00000013454 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000055208
TAB3 GeneProduct ensembl:ENSBTAG00000048159 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157625
MAP2K6 GeneProduct ensembl:ENSBTAG00000001609 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108984
MAP2K4 GeneProduct ensembl:ENSBTAG00000012103 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000065559
MAP2K7 GeneProduct ensembl:ENSBTAG00000010639 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000076984
MAP2K1 GeneProduct ensembl:ENSBTAG00000033983 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169032
MAP2K2 GeneProduct ensembl:ENSBTAG00000024450 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000126934
TANK GeneProduct ensembl:ENSBTAG00000006654 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136560
IKBKB GeneProduct ensembl:ENSBTAG00000007599 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104365
MAPK14 GeneProduct ensembl:ENSBTAG00000020783 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112062
MAPK9 GeneProduct ensembl:ENSBTAG00000004709 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P45984
MAPK10 GeneProduct ensembl:ENSBTAG00000020048 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P53779
MAPK1 GeneProduct ensembl:ENSBTAG00000010312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100030
NFKBIB GeneProduct ensembl:ENSBTAG00000001778 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q15653
ATF2 GeneProduct ensembl:ENSBTAG00000002295 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115966
MKNK1 GeneProduct ensembl:ENSBTAG00000019933 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079277
MAPK9 GeneProduct ensembl:ENSBTAG00000004709 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000050748
FOS GeneProduct ensembl:ENSBTAG00000004322 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170345
MKNK2 GeneProduct ensembl:ENSBTAG00000018049 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099875
EIF4E GeneProduct ensembl:ENSBTAG00000009522 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151247

References

  1. Mammalian MAP kinase signalling cascades. Chang L, Karin M. Nature. 2001 Mar 1;410(6824):37–40. PubMed Europe PMC Scholia
  2. Annotating genes with potential roles in the immune system: six new members of the IL-1 family. Dunn E, Sims JE, Nicklin MJ, O’Neill LA. Trends Immunol. 2001 Oct;22(10):533–6. PubMed Europe PMC Scholia
  3. A new nomenclature for IL-1-family genes. Sims JE, Nicklin MJ, Bazan JF, Barton JL, Busfield SJ, Ford JE, et al. Trends Immunol. 2001 Oct;22(10):536–7. PubMed Europe PMC Scholia
  4. Increased expression of interleukin-1 receptor type 1 in active endometriotic lesions. Lawson C, Al-Akoum M, Maheux R, Akoum A. Reproduction. 2007 Jan;133(1):265–74. PubMed Europe PMC Scholia
  5. Cloning IL-1 and the birth of a new era in cytokine biology. Pizarro TT, Cominelli F. J Immunol. 2007 May 1;178(9):5411–2. PubMed Europe PMC Scholia
  6. The inflammasomes: guardians of the body. Martinon F, Mayor A, Tschopp J. Annu Rev Immunol. 2009;27:229–65. PubMed Europe PMC Scholia
  7. O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release. Pathak S, Borodkin VS, Albarbarawi O, Campbell DG, Ibrahim A, van Aalten DM. EMBO J. 2012 Mar 21;31(6):1394–404. PubMed Europe PMC Scholia
  8. The structural pathway of interleukin 1 (IL-1) initiated signaling reveals mechanisms of oncogenic mutations and SNPs in inflammation and cancer. Acuner Ozbabacan SE, Gursoy A, Nussinov R, Keskin O. PLoS Comput Biol. 2014 Feb 13;10(2):e1003470. PubMed Europe PMC Scholia