Hematopoietic stem cell differentiation (WP3174)

Bos taurus

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Growth factors and miRNA regulating differentiation of hematopoietic stem cells (HSC) to various blood-related cell types. Note that myeloblasts branch off separately from erythrocytes and megakaryocytes. Adapted from an open access image attributed to ZooFari and Mikael Häggström (http://en.wikipedia.org/wiki/User:Mikael_H%C3%A4ggstr%C3%B6m/Gallery#Medical_collaborations) and augmented from literature and NHLBI Progenitor Cell Biology Consortium (PCBC) collaborators.

Authors

Martina Summer-Kutmon and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

Interleukin mediated signaling pathway

Cell Type Ontology

peripheral blood stem cell

Participants

Label Type Compact URI Comment
NFATC2 GeneProduct ensembl:ENSBTAG00000018270 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101096
KCNH2 GeneProduct ensembl:ENSBTAG00000004078 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000055118
IKZF1 GeneProduct ensembl:ENSBTAG00000014016 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185811
LYL1 GeneProduct ensembl:ENSBTAG00000019329 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104903
STAT5A GeneProduct ensembl:ENSBTAG00000009496 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000126561
MYB GeneProduct ensembl:ENSBTAG00000012074 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118513
SPI1 GeneProduct ensembl:ENSBTAG00000021709 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000066336
VAV1 GeneProduct ensembl:ENSBTAG00000039160 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141968
CBFA2T3 GeneProduct ensembl:ENSBTAG00000010927 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000129993
KLF1 GeneProduct ensembl:ENSBTAG00000006083 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105610
FOS GeneProduct ensembl:ENSBTAG00000004322 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170345
TRIM29 GeneProduct ensembl:ENSBTAG00000009419 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137699
LMO2 GeneProduct ensembl:ENSBTAG00000006951 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135363
NCKAP1L GeneProduct ensembl:ENSBTAG00000019686 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123338
CSF3 GeneProduct ensembl:ENSBTAG00000021462 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108342
IL5 GeneProduct ensembl:ENSBTAG00000031235 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113525
CSF1 GeneProduct ensembl:ENSBTAG00000000283 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184371
GATA1 GeneProduct ensembl:ENSBTAG00000003184 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102145
KITLG GeneProduct ensembl:ENSBTAG00000017549 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000049130
EPO GeneProduct ensembl:ENSBTAG00000003430 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130427
IL6 GeneProduct ensembl:ENSBTAG00000014921 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136244
IL1A GeneProduct ensembl:ENSBTAG00000010349 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115008
CSF2 GeneProduct ensembl:ENSBTAG00000001570 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164400
IL1B GeneProduct ensembl:ENSBTAG00000001321 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125538
CXCR4 GeneProduct ensembl:ENSBTAG00000001060 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000121966
MXI1 GeneProduct ensembl:ENSBTAG00000017263 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000119950
RIOK3 GeneProduct ensembl:ENSBTAG00000010042 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101782
ACVR1B GeneProduct ensembl:ENSBTAG00000013555 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135503
bta-mir-16a GeneProduct ensembl:ENSBTAG00000036389 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000208006
ABO GeneProduct ensembl:ENSBTAG00000012525 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175164
ITGA2B GeneProduct ensembl:ENSBTAG00000008165 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000005961
GP9 GeneProduct ensembl:ENSBTAG00000014666 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169704
RUNX1 GeneProduct ensembl:ENSBTAG00000004742 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159216
NOTCH1 GeneProduct ensembl:ENSBTAG00000022799 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148400
GATA2 GeneProduct ensembl:ENSBTAG00000019707 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000179348
NFE2 GeneProduct ensembl:ENSBTAG00000001562 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123405
INTB3 GeneProduct ensembl:ENSBTAG00000009987 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3690

References

  1. The role of micro-ribonucleic acids in normal hematopoiesis and leukemic T-lymphogenesis. Slavov SN, Gimenes Teixeira HL, Rego EM. Braz J Med Biol Res. 2010 Jul;43(7):619–26. PubMed Europe PMC Scholia
  2. MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment. Zhang L, Sankaran VG, Lodish HF. Leukemia. 2012 Nov;26(11):2310–6. PubMed Europe PMC Scholia
  3. Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Riddell J, Gazit R, Garrison BS, Guo G, Saadatpour A, Mandal PK, et al. Cell. 2014 Apr 24;157(3):549–64. PubMed Europe PMC Scholia