Estrogen receptor pathway (WP3163)

Bos taurus

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The estrogen receptor is a nuclear receptor that is activated upon ligand binding and subsequently translocates to the nuclear. There, it activates transcription of target genes involved in essential cellular processes. The ER receptor has been implicated in a multitude of diseases, most notably cancer (breast/ovarian)

Authors

Martina Summer-Kutmon and Eric Weitz

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

estrogen signaling pathway

Participants

Label Type Compact URI Comment
Ligand Metabolite chebi:48705
SP1 GeneProduct ensembl:ENSBTAG00000003021 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185591
ESR1 GeneProduct ensembl:ENSBTAG00000007159 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091831
JUN GeneProduct ensembl:ENSBTAG00000004037 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000177606
PDK4 GeneProduct ensembl:ENSBTAG00000014069 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000004799
STAT3 GeneProduct ensembl:ENSBTAG00000021523 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168610
ACOX1 GeneProduct ensembl:ENSBTAG00000030174 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000161533
GPAM GeneProduct ensembl:ENSBTAG00000011917 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000119927
PCK1 GeneProduct ensembl:ENSBTAG00000001936 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124253
CYP1A1 GeneProduct ensembl:ENSBTAG00000001021 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140465
PPARA GeneProduct ensembl:ENSBTAG00000008063 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186951
CYP1A2 GeneProduct ensembl:ENSBTAG00000000085 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140505
NR0B2 GeneProduct ensembl:ENSBTAG00000014848 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131910
CYP1B1 GeneProduct ensembl:ENSBTAG00000010531 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138061

References

  1. Estrogen receptors: therapies targeted to receptor subtypes. Nilsson S, Gustafsson JÅ. Clin Pharmacol Ther. 2011 Jan;89(1):44–55. PubMed Europe PMC Scholia
  2. Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Fijten RRR, Jennen DGJ, van Delft JHM. Curr Drug Metab. 2013 Dec;14(10):1022–8. PubMed Europe PMC Scholia