Extracellular vesicle-mediated signaling in recipient cells (WP3161)
Bos taurus
Protein sorting during formation of multivesicular bodies results in packaging of key molecules in exosomes. Exosomes bound-signaling ligands once released from host cells interacts with the receptors on the recipient cells to induce downstream signaling cascades pivotal in the initiation and progression of cancer. This horizontal transfer of proteomic content of exosomes can mediate signaling pathways including Wnt, PI3K and TGF-beta in recipient cells.
Authors
Martina Summer-Kutmon and Susan CoortActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Bos taurusCommunities
Annotations
Disease Ontology
cancer nervous system diseasePathway Ontology
signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| SMAD4 | GeneProduct | ensembl:ENSBTAG00000006919 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4089 |
| SMAD2 | GeneProduct | ensembl:ENSBTAG00000039916 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4087 |
| SMAD3 | GeneProduct | ensembl:ENSBTAG00000012599 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4088 |
| WNT3A | GeneProduct | ensembl:ENSBTAG00000039397 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:89780 |
| WNT5A | GeneProduct | ensembl:ENSBTAG00000020221 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7474 |
| ERBB2 | GeneProduct | ensembl:ENSBTAG00000021798 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2064 |
| EGFR | GeneProduct | ensembl:ENSBTAG00000011628 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1956 |
| MFGE8 | GeneProduct | ensembl:ENSBTAG00000003300 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4240 |
| TSPAN8 | GeneProduct | ensembl:ENSBTAG00000019425 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7103 |
| DKK4 | GeneProduct | ensembl:ENSBTAG00000000226 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27121 |
| TGFA | GeneProduct | ensembl:ENSBTAG00000000783 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7039 |
| TGFB1 | GeneProduct | ensembl:ENSBTAG00000020457 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040 |
| PROM1 | GeneProduct | ensembl:ENSBTAG00000013736 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8842 |
| AKT1 | GeneProduct | ensembl:ENSBTAG00000017636 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207 |
| MTOR | GeneProduct | ensembl:ENSBTAG00000015325 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475 |
| HGF | GeneProduct | ensembl:ENSBTAG00000017664 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3082 |
| C-MET | GeneProduct | ensembl:ENSBTAG00000006161 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4233 |
| PIK3R5 | GeneProduct | ensembl:ENSBTAG00000005978 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23533 |
| HRAS | GeneProduct | ensembl:ENSBTAG00000046644 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265 |
| RAF1 | GeneProduct | ensembl:ENSBTAG00000045748 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894 |
| TGFBR1 | GeneProduct | ensembl:ENSBTAG00000018035 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7046 |
| TGFBR3 | GeneProduct | ensembl:ENSBTAG00000024269 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7049 |
| TGFB1 | GeneProduct | ensembl:ENSBTAG00000020457 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040 |
| TGFB2 | GeneProduct | ensembl:ENSBTAG00000005359 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7042 |
| TGFB3 | GeneProduct | ensembl:ENSBTAG00000012004 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7043 |
| APC | GeneProduct | ensembl:ENSBTAG00000018852 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:324 |
| AXIN1 | GeneProduct | ensembl:ENSBTAG00000016577 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8312 |
| CTNNB1 | GeneProduct | ensembl:ENSBTAG00000016420 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1499 |
| AKT1 | GeneProduct | ensembl:ENSBTAG00000017636 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207 |
| NRAS | Protein | ensembl:ENSBTAG00000046797 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4893 |
| TGFBR2 | Protein | ensembl:ENSBTAG00000019832 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7048 |
References
- Extracellular vesicles including exosomes are mediators of signal transduction: are they protective or pathogenic? Gangoda L, Boukouris S, Liem M, Kalra H, Mathivanan S. Proteomics. 2015 Jan;15(2–3):260–71. PubMed Europe PMC Scholia