Diclofenac metabolic pathway (WP3152)

Bos taurus

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
CYP metabolism of the diclofenac drug.

Authors

Martina Summer-Kutmon and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

phase I biotransformation pathway via cytochrome P450

Participants

Label Type Compact URI Comment
diclofenac Metabolite pubchem.compound:3033
3'-Hydroxydiclofenac Metabolite pubchem.compound:112230
4'-hydroxydiclofenac Metabolite pubchem.compound:116545
5-hydroxydiclofenac Metabolite pubchem.compound:3052566
Metabolite Metabolite pubchem.compound:10065052
4',5-Dihydroxydiclofenac Metabolite pubchem.compound:3052567
CYP2B6 Protein ensembl:ENSBTAG00000003871 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P20813
CYP2C8 Protein ensembl:ENSBTAG00000020375 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P10632
CYP2C18 Protein ensembl:ENSBTAG00000020375 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P33260
CYP2C19 Protein ensembl:ENSBTAG00000020375 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P33261

References

  1. Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways. Bort R, Macé K, Boobis A, Gómez-Lechón MJ, Pfeifer A, Castell J. Biochem Pharmacol. 1999 Sep 1;58(5):787–96. PubMed Europe PMC Scholia