Trans-sulfuration pathway (WP3145)

Bos taurus

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Trans-sulfuration pathway, the pathway of production of GSH from S-adenosylmethionine (SAMe). Evidences have been showed that this pathway was perturbed in liver toxicity studies.

Authors

Martina Summer-Kutmon

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

glutathione metabolic pathway

Participants

Label Type Compact URI Comment
Tetrahydrofolate (THF) Metabolite kegg.compound:C00101
L-Methionine Metabolite kegg.compound:C00073
5-Methyl-THF Metabolite kegg.compound:C00440
L-Homocysteine Metabolite kegg.compound:C00155
S-Adenosylmethionine (SAMe) Metabolite kegg.compound:C00019
S-Adenosylhomocysteine (SAH) Metabolite kegg.compound:C00021
L-Cysteine Metabolite kegg.compound:C00097
Glutathione Metabolite kegg.compound:C00051
Taurine Metabolite kegg.compound:C00245
L-Glutamate Metabolite kegg.compound:C00025
Pyruvate Metabolite kegg.compound:C00022
ATP Metabolite kegg.compound:C00002
ADP Metabolite kegg.compound:C00008
Phosphate Metabolite kegg.compound:C00009
MTR GeneProduct ensembl:ENSBTAG00000012251 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4548
MAT2B GeneProduct ensembl:ENSBTAG00000012350 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27430
DNMT1 GeneProduct ensembl:ENSBTAG00000002736 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1786
AHCY GeneProduct ensembl:ENSBTAG00000018101 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:191
CBS GeneProduct ensembl:ENSBTAG00000000160 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:875
CTH GeneProduct ensembl:ENSBTAG00000014791 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1491
GOT1 GeneProduct ensembl:ENSBTAG00000011960 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2805
MPST GeneProduct ensembl:ENSBTAG00000030648 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4357
GCLM GeneProduct ensembl:ENSBTAG00000007842 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2730
CSAD GeneProduct ensembl:ENSBTAG00000007829 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51380

References

  1. Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity. Beger RD, Sun J, Schnackenberg LK. Toxicol Appl Pharmacol. 2010 Mar 1;243(2):154–66. PubMed Europe PMC Scholia