Histone modifications (WP3123)

Bos taurus

Histones can undergo many post-translational modifications that are involved in transcription regulation. This pathway provides an overview of various modifications for histones H3 and H4 and the enzymes that catalyze the modifications, where known.

Authors

Martina Summer-Kutmon and Eric Weitz

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

altered transcription pathway

Participants

Label Type Compact URI Comment
ASH1L GeneProduct ensembl:ENSBTAG00000003954 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116539
H3F3A GeneProduct ensembl:ENSBTAG00000024561 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163041
HIST1H3D GeneProduct ensembl:ENSBTAG00000031766 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197409
HIST1H3J GeneProduct ensembl:ENSBTAG00000031717 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197153
DOT1L GeneProduct ensembl:ENSBTAG00000009996 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104885
EHMT1 GeneProduct ensembl:ENSBTAG00000012148 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181090
BAT8 GeneProduct ensembl:ENSBTAG00000005676 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10919
EZH1 GeneProduct ensembl:ENSBTAG00000021918 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108799
EZH2 GeneProduct ensembl:ENSBTAG00000009426 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106462
KMT2A GeneProduct ensembl:ENSBTAG00000018093 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118058
KMT2D GeneProduct ensembl:ENSBTAG00000014429 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167548
KMT2C GeneProduct ensembl:ENSBTAG00000024199 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000055609
KMT2E GeneProduct ensembl:ENSBTAG00000009207 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000005483
NSD1 GeneProduct ensembl:ENSBTAG00000025426 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165671
PRDM2 GeneProduct ensembl:ENSBTAG00000020552 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116731
SET GeneProduct ensembl:ENSBTAG00000020959 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000119335
SETBP1 GeneProduct ensembl:ENSBTAG00000018088 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152217
SETD1A GeneProduct ensembl:ENSBTAG00000002345 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099381
SETD1B GeneProduct ensembl:ENSBTAG00000004172 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139718
SETD2 GeneProduct ensembl:ENSBTAG00000002948 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181555
SETD3 GeneProduct ensembl:ENSBTAG00000018310 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183576
SETD4 GeneProduct ensembl:ENSBTAG00000018682 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185917
SETD5 GeneProduct ensembl:ENSBTAG00000019193 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168137
SETD6 GeneProduct ensembl:ENSBTAG00000020781 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103037
SETD7 GeneProduct ensembl:ENSBTAG00000003581 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000145391
SETD8 GeneProduct ensembl:ENSBTAG00000000139 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000183955
SETD9 GeneProduct ensembl:ENSBTAG00000013426 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000155542
SETDB1 GeneProduct ensembl:ENSBTAG00000000098 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143379
SETDB2 GeneProduct ensembl:ENSBTAG00000007329 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136169
SETMAR GeneProduct ensembl:ENSBTAG00000018935 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170364
SMYD1 GeneProduct ensembl:ENSBTAG00000021120 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115593
SMYD2 GeneProduct ensembl:ENSBTAG00000013166 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143499
SMYD3 GeneProduct ensembl:ENSBTAG00000033180 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185420
SMYD4 GeneProduct ensembl:ENSBTAG00000009708 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186532
SMYD5 GeneProduct ensembl:ENSBTAG00000008764 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135632
SUV39H1 GeneProduct ensembl:ENSBTAG00000004706 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101945
SUV39H2 GeneProduct ensembl:ENSBTAG00000010210 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152455
SUV420H1 GeneProduct ensembl:ENSBTAG00000001185 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110066
SUV420H2 GeneProduct ensembl:ENSBTAG00000014087 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000133247
EED GeneProduct ensembl:ENSBTAG00000007847 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000074266
AEBP2 GeneProduct ensembl:ENSBTAG00000010818 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139154
HIST1H4C GeneProduct ensembl:ENSBTAG00000032259 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197061

References

  1. Regulation of chromatin structure by site-specific histone H3 methyltransferases. Rea S, Eisenhaber F, O’Carroll D, Strahl BD, Sun ZW, Schmid M, et al. Nature. 2000 Aug 10;406(6796):593–9. PubMed Europe PMC Scholia
  2. COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. Krogan NJ, Dover J, Khorrami S, Greenblatt JF, Schneider J, Johnston M, et al. J Biol Chem. 2002 Mar 29;277(13):10753–5. PubMed Europe PMC Scholia
  3. Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression. Strahl BD, Grant PA, Briggs SD, Sun ZW, Bone JR, Caldwell JA, et al. Mol Cell Biol. 2002 Mar;22(5):1298–306. PubMed Europe PMC Scholia
  4. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D. Genes Dev. 2002 Nov 15;16(22):2893–905. PubMed Europe PMC Scholia
  5. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, et al. Genes Dev. 2004 Jun 1;18(11):1251–62. PubMed Europe PMC Scholia