Iron metabolism in placenta (WP2908)

Bos taurus

During pregnancy, iron is transported from mother to fetus across the placenta. Iron is essential for many biological processes, including the transfer of oxygen in blood, but it can also be toxic. Elaborate and elegant mechanisms have evolved to make sure that the potential for oxidative damage is minimized. This description of Iron pathway through the placenta, and its regulation is purposed to understand the effect of Iron deficiency or Iron overload of the mother on the fetus.

Authors

Martina Summer-Kutmon

Activity

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

iron homeostasis pathway iron transport pathway

Participants

Label Type Compact URI Comment
FeIII Metabolite cas:20074-52-6
FeII Metabolite cas:15438-31-0
STEAP3 GeneProduct ensembl:ENSBTAG00000007111 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115107
SLC40A1 GeneProduct ensembl:ENSBTAG00000010498 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138449
HEPHL1 GeneProduct ensembl:ENSBTAG00000022960 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181333
ACO1 GeneProduct ensembl:ENSBTAG00000000555 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000122729
IREB2 GeneProduct ensembl:ENSBTAG00000002504 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136381
SLC11A2 GeneProduct ensembl:ENSBTAG00000002355 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110911
MCOLN1 GeneProduct ensembl:ENSBTAG00000005592 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000090674
TFR2 GeneProduct ensembl:ENSBTAG00000011738 Transferrin receptor
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106327
TF Protein ensembl:ENSBTAG00000007273 Transferrin
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091513
TFRC Protein ensembl:ENSBTAG00000032719 Transferrin receptor
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000072274
HAMP Protein ensembl:ENSBTAG00000017042 HAMP
HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105697
HAMP Protein ensembl:ENSBTAG00000017042 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105697

References

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