Growth hormone (GH) signaling

Zahra Roudbari; Martina Summer-Kutmon; Eric Weitz

Growth hormone (GH) signaling (WP2890)

Bos taurus

The growth Hormone/Insulin-Like Growth Factor axis is a complex system of ligands, binding protein and receptors which the cells use for communication of growth simulating signal. GH is released from the pituitary and by binding to the GH receptor it stimulates longitudinal growth and has anabolic effects on metabolism. Most of the growth-promoting effects of GH are mediated by IGF-1 which is produced mainly in the liver after GH stimulation. IGF-1 has crucial functions especially for embryonic growth and development. This pathway is primarily studied to understand factors that contribute to growth in bos taurus(Jiang et al.)

Authors

Zahra Roudbari , Martina Summer-Kutmon , and Eric Weitz

Activity

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Identification of Biological Pathways Contributing to Marbling in Skeletal Muscle to Improve Beef Cattle Breeding (2020).

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

growth factor signaling pathway

Participants

Label	Type	Compact URI
GHR	GeneProduct	ncbigene:280805
IGFBP-3	GeneProduct	ncbigene:282261
IGF-1	GeneProduct	ncbigene:281239
STAT5b	GeneProduct	ncbigene:282376
GH1	GeneProduct	ncbigene:280804
JAK2	GeneProduct	ncbigene:525246

References

MEAT SCIENCE AND MUSCLE BIOLOGY SYMPOSIUM--mechanism of growth hormone stimulation of skeletal muscle growth in cattle. Jiang H, Ge X. J Anim Sci. 2014 Jan;92(1):21–9. PubMed Europe PMC Scholia