Cell cycle (WP1393)

Danio rerio

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(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.

Authors

Martijn Van Iersel , Martina Summer-Kutmon , Levi Wackers , and Lauren J. Dupuis

Activity

last edited

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Organisms

Danio rerio

Communities

Annotations

Pathway Ontology

cell cycle pathway

Participants

Label Type Compact URI Comment
pttg1 GeneProduct ensembl:ENSDARG00000075421 PTTG1; pituitary tumor-transforming
cdkn2a/b GeneProduct ensembl:ENSDARG00000037262
ywhag1 GeneProduct ensembl:ENSDARG00000067626 YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid
cdk6 GeneProduct ncbigene:100034507 CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
ccna2 GeneProduct ncbigene:192295 CCNA2; cyclin A2
cdc20 GeneProduct ncbigene:406353 CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
MPEG1 GeneProduct ncbigene:335407
ccne2 GeneProduct ncbigene:415165 CCNE2; cyclin E
cdc25 GeneProduct ncbigene:57925 CDC25B; cell division cycle 25B [EC:3.1.3.48]
zgc:85772 GeneProduct ncbigene:406462 ORC4L; origin recognition complex subunit 4-like (yeast)
rb1 GeneProduct ncbigene:777733 RB1; retinoblastoma 1 (including osteosarcoma)
tbc1d8 GeneProduct ensembl:ENSDARG00000104493
hdac4 GeneProduct ncbigene:568877 HDAC4; histone deacetylase 4
ccnd2a GeneProduct ncbigene:799608 CCND2; cyclin D2
wu:fa96e12 GeneProduct ncbigene:562283 PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
smc1a GeneProduct ncbigene:559665 SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
ep300a GeneProduct ncbigene:559273 EP300; E1A binding protein p300
orc3 GeneProduct ncbigene:334315 ORC3L; origin recognition complex subunit 3-like (yeast)
bub3 GeneProduct ncbigene:403012 BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
chek2 GeneProduct ncbigene:336998 CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
HDAC7A GeneProduct ensembl:ENSDARG00000105179 HDAC7A; histone deacetylase 7
rb1 GeneProduct ncbigene:777733 RB1; retinoblastoma 1 (including osteosarcoma)
MEN GeneProduct ensembl:ENSDARG00000000568
mdm2 GeneProduct ncbigene:30637 MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
mcm7 GeneProduct ensembl:ENSDARG00000101180 MCM7; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
DKEY-168J9.1 GeneProduct ncbigene:565969 CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
hdac8 GeneProduct ncbigene:406740 HDAC8; histone deacetylase
ccnh GeneProduct ncbigene:541325 CCNH; cyclin H
espl1 GeneProduct ncbigene:797406 ESPL1; extra spindle poles like 1 (S. cerevisiae
hdac1 GeneProduct ncbigene:192302 HDAC1; histone deacetylase 1
cdkn1b GeneProduct ncbigene:368329 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
rbl1 GeneProduct ncbigene:795522
mad2l1 GeneProduct ncbigene:550434 MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
ccnb2 GeneProduct ncbigene:368316 CCNB2; cyclin B2
cdk2 GeneProduct ncbigene:406715 CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
LOC557486 GeneProduct ncbigene:557486 HDAC5; histone deacetylase 5
UBE2F GeneProduct ensembl:ENSDARG00000025754 UBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans
bub1bb GeneProduct ncbigene:567006 BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
orc1 GeneProduct ncbigene:554509 ORC1L; origin recognition complex subunit 1-like (yeast)
hdac6 GeneProduct ncbigene:565482 HDAC6; histone deacetylase 6
mad1l1 GeneProduct ncbigene:393886 MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
smad3b GeneProduct ncbigene:326283 MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
cdc45l GeneProduct ncbigene:406695 CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
ccne GeneProduct ncbigene:30188 CCNE1; cyclin E
zgc:153369 GeneProduct ncbigene:767751 CCNB3; cyclin B
ccna2 GeneProduct ncbigene:192295 CCNA2; cyclin A2
tfdp1a GeneProduct ncbigene:406813 TFDP1; transcription factor Dp-1
e2f3 GeneProduct ensembl:ENSDARG00000070463 E2F3; E2F transcription factor 3
wee1 GeneProduct ncbigene:327060 WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
cdk2 GeneProduct ncbigene:406715 CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
CDH1 GeneProduct ncbigene:114424
CCND3 GeneProduct ensembl:ENSDARG00000027391 CCND3; cyclin D3
TGFB1 GeneProduct ncbigene:359834
rbl1 GeneProduct ncbigene:795522 RBL1; retinoblastoma-like 1 (p107)
cdk4 GeneProduct ncbigene:777730 CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
kitlgb GeneProduct ensembl:ENSDARG00000058042
cdc25b GeneProduct ensembl:ENSDARG00000010792 CDC25A; cell division cycle 25A [EC:3.1.3.48]
cdc25b is zebrafish ortholog of human CDC25A
tp53 GeneProduct ncbigene:30590
atm GeneProduct ensembl:ENSDARG00000002385 ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
abl1 GeneProduct ncbigene:100000720 ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
zgc:174506 GeneProduct ncbigene:402825 CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
skp2 GeneProduct ncbigene:563708 SKP2; S-phase kinase-associated protein 2 (p45
ccna1 GeneProduct ncbigene:404206 CCNA1; cyclin A1
LOC559111 GeneProduct ncbigene:559111 MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
ccnb1 GeneProduct ncbigene:58025 CCNB1; cyclin B1
CDKN1A GeneProduct ncbigene:100151416
cdk2 GeneProduct ncbigene:406715 CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
e2f1 GeneProduct ensembl:ENSDARG00000103868 E2F1; E2F transcription factor 1
atr GeneProduct ensembl:ENSDARG00000079625 ATR; ataxia telangiectasia and Rad3 related
e2f4 GeneProduct ncbigene:406741 E2F4; E2F transcription factor 4 p107/p130-binding
hdac3 GeneProduct ncbigene:393965 HDAC3; histone deacetylase 3
mcm6 GeneProduct ncbigene:566409 MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae)
chek1 GeneProduct ncbigene:393162 CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
mcm4 GeneProduct ncbigene:337598 MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae
ccna1 GeneProduct ncbigene:404206 CCNA1; cyclin A1
bub1 GeneProduct ensembl:ENSDARG00000077029 BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
rb1 GeneProduct ncbigene:777733 RB1; retinoblastoma 1 (including osteosarcoma)
orc5 GeneProduct ncbigene:406479 ORC5L; origin recognition complex subunit 5-like (yeast)
zgc:163016 GeneProduct ncbigene:100049158 PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
mcm2 GeneProduct ncbigene:192338 MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae
mad2l2 GeneProduct ensembl:ENSDARG00000042456 MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
e2f2 GeneProduct ensembl:ENSDARG00000079233 E2F2; E2F transcription factor 2
cdc2 GeneProduct ncbigene:80973 CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
plk1 GeneProduct ncbigene:280649 PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
orc2 GeneProduct ensembl:ENSDARG00000101465 ORC2L; origin recognition complex subunit 2-like (yeast)
mcm5 GeneProduct ncbigene:286747 MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae)
gsk3b GeneProduct ncbigene:30654 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
cdc2 GeneProduct ncbigene:80973 CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
GADD45A GeneProduct ncbigene:431763
orc6l GeneProduct ncbigene:324256 ORC6L; origin recognition complex subunit 6-like (yeast)
mcm3 GeneProduct ncbigene:192323 MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
zgc:101602 GeneProduct ncbigene:492768 CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
cdc14b GeneProduct ncbigene:393148 CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
si:ch211-195d17.2 GeneProduct ncbigene:560495 E2F6; E2F transcription factor 6
pcna GeneProduct ncbigene:30678 PCNA; proliferating cell nuclear antigen
e2f5 GeneProduct ncbigene:402908 E2F5; E2F transcription factor 5 p130-binding
kitlga GeneProduct ensembl:ENSDARG00000070917
kitlgb GeneProduct ensembl:ENSDARG00000058042
skp2 GeneProduct ncbigene:563708 SKP2; S-phase kinase-associated protein 2 (p45
kitlga GeneProduct ensembl:ENSDARG00000070917
ywhag2 GeneProduct ensembl:ENSDARG00000071658 YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid

References

  1. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, et al. Science. 1998 Sep 11;281(5383):1677–9. PubMed Europe PMC Scholia