Selenium metabolism selenoproteins (WP1358)

Danio rerio

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* Comments belonging to specific genes on the Selenoprotein pathway ** TRXND3 gene: Although the geneID is correct, the sequence of this gene was guessed by analogy. ** Cystathionine gamma-lyase is the mammalian form of bacterial methionine gamma-lyase ** A selenoprotein database exists at: http://www.selenodb.org.

Authors

Martina Summer-Kutmon , Linda Rieswijk , and Eric Weitz

Activity

last edited

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Organisms

Danio rerio

Communities

Annotations

Pathway Ontology

selenoamino acid metabolic pathway

Participants

Label Type Compact URI Comment
SeC Metabolite hmdb:HMDB0003288
SeC Metabolite hmdb:HMDB0003288
SeMet Metabolite hmdb:HMDB0003966
Selenophosphate Metabolite hmdb:HMDB0006407
SeMet Metabolite hmdb:HMDB0003966
sepm GeneProduct ncbigene:352913
TXNRD3 GeneProduct ncbigene:352925
selenbp1 GeneProduct ncbigene:393542
sepn1 GeneProduct ncbigene:352914
TXNRD1 GeneProduct ncbigene:352924
LOC557632 GeneProduct ncbigene:557632
trnau1apl GeneProduct ncbigene:791478
Nfe2l2 GeneProduct ncbigene:360149
Sep15 GeneProduct ncbigene:352923
gpx4a GeneProduct ncbigene:352928
sepx1 GeneProduct ncbigene:352916
jun GeneProduct ensembl:ENSDARG00000043531
sars2 GeneProduct ncbigene:394154
sps2 GeneProduct ncbigene:352933
zgc:136970 GeneProduct ncbigene:735249
selt1a GeneProduct ncbigene:352919
zgc:171514 GeneProduct ncbigene:559537
seph GeneProduct ncbigene:347743
sepp1a GeneProduct ncbigene:352931
rela GeneProduct ncbigene:415099
sepw1 GeneProduct ncbigene:352915
zgc:103591 GeneProduct ncbigene:791738
fos GeneProduct ensembl:ENSDARG00000031683
dio1 GeneProduct ncbigene:799937
GPX3 GeneProduct ncbigene:798788
Sephs1 GeneProduct ncbigene:324947
Sars GeneProduct ncbigene:445405
eefsec GeneProduct ncbigene:641497
TXNRD1 GeneProduct ncbigene:352924
si:ch211-15i6.2 GeneProduct ncbigene:558648
TXNRD3 GeneProduct ncbigene:352925
Sp1 GeneProduct ncbigene:324109
rpl30 GeneProduct ncbigene:336713
sp3 GeneProduct ncbigene:558652
sepsecs GeneProduct ncbigene:393123
eefsec GeneProduct ncbigene:641497
dio2 GeneProduct ncbigene:352937
fabp1a GeneProduct ncbigene:791610

References

  1. Temporal changes in tissue glutathione in response to chemical form, dose, and duration of selenium treatment. Relevance to cancer chemoprevention by selenium. Thompson HJ, Clement IP. Biol Trace Elem Res. 1991 Aug;30(2):163–73. PubMed Europe PMC Scholia
  2. Tissue selenium levels in selenium-supplemented rats and their relevance in mammary cancer protection. Ip C, Hayes C. Carcinogenesis. 1989 May;10(5):921–5. PubMed Europe PMC Scholia
  3. Vitamin B6 enzymes participating in selenium amino acid metabolism. Soda K, Oikawa T, Esaki N. Biofactors. 1999;10(2–3):257–62. PubMed Europe PMC Scholia
  4. Bioactivation of selenocysteine Se-conjugates by a highly purified rat renal cysteine conjugate beta-lyase/glutamine transaminase K. Commandeur JN, Andreadou I, Rooseboom M, Out M, de Leur LJ, Groot E, et al. J Pharmacol Exp Ther. 2000 Aug;294(2):753–61. PubMed Europe PMC Scholia
  5. Effectiveness of selenium supplements in a low-selenium area of China. Xia Y, Hill KE, Byrne DW, Xu J, Burk RF. Am J Clin Nutr. 2005 Apr;81(4):829–34. PubMed Europe PMC Scholia
  6. Human selenoproteins at a glance. Gromer S, Eubel JK, Lee BL, Jacob J. Cell Mol Life Sci. 2005 Nov;62(21):2414–37. PubMed Europe PMC Scholia
  7. Unique features of selenocysteine incorporation function within the context of general eukaryotic translational processes. Small-Howard AL, Berry MJ. Biochem Soc Trans. 2005 Dec;33(Pt 6):1493–7. PubMed Europe PMC Scholia
  8. Biosynthesis of selenocysteine on its tRNA in eukaryotes. Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, et al. PLoS Biol. 2007 Jan;5(1):e4. PubMed Europe PMC Scholia
  9. Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice. Wang H, Zhang J, Yu H. Free Radic Biol Med. 2007 May 15;42(10):1524–33. PubMed Europe PMC Scholia
  10. From selenium to selenoproteins: synthesis, identity, and their role in human health. Papp LV, Lu J, Holmgren A, Khanna KK. Antioxid Redox Signal. 2007 Jul;9(7):775–806. PubMed Europe PMC Scholia
  11. The role of selenium in chronic disease. Boosalis MG. Nutr Clin Pract. 2008;23(2):152–60. PubMed Europe PMC Scholia