Adipogenesis (WP1105)

Canis familiaris

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The different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, composed of white and brown adipose tissue, is composed of adipocytes. This pathway is primarily studied to understand factors that contribute to obesity and diabetes. Transcriptional and hormonal regulators of adipocyte formation are indicated.

Authors

Martijn Van Iersel and Martina Summer-Kutmon

Activity

last edited

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Organisms

Canis familiaris

Communities

Annotations

Pathway Ontology

signaling pathway pertinent to development

Participants

Label Type Compact URI Comment
IGF1 GeneProduct ncbigene:610255
PTGIS GeneProduct ncbigene:485919
PPARD GeneProduct ncbigene:481756
CREB1 GeneProduct ncbigene:607922
ID3 GeneProduct ncbigene:403547
WNT10B GeneProduct ncbigene:486561
STAT5A GeneProduct ncbigene:490968
STAT5B GeneProduct ncbigene:490969
DLK1 GeneProduct ncbigene:490860
NR3C1 GeneProduct ncbigene:478047
DDIT3 GeneProduct ncbigene:607439
LIF GeneProduct ncbigene:403449
LOC486804 GeneProduct ncbigene:486804
LOC483120 GeneProduct ncbigene:483120
RXRA GeneProduct ncbigene:491278
RARA GeneProduct ncbigene:480526
NR1H3 GeneProduct ncbigene:483625
LPL GeneProduct ncbigene:403626
SREBF1 GeneProduct ncbigene:403475
FAS GeneProduct ncbigene:486469
RBL1 GeneProduct ncbigene:477221
GATA3 GeneProduct ncbigene:487134
GATA2 GeneProduct ncbigene:484626
PPARG GeneProduct ncbigene:403606
MEF2A GeneProduct ncbigene:479021
MEF2B GeneProduct ncbigene:609739
MEF2C GeneProduct ncbigene:479155
ASIP GeneProduct ncbigene:492296
TNF GeneProduct ncbigene:403922
MIF GeneProduct ncbigene:595146
TGFB1 GeneProduct ncbigene:403998
SERPINE1 GeneProduct ncbigene:403476
SLC2A4 GeneProduct ncbigene:403673
SCD GeneProduct ncbigene:486839
TWIST1 GeneProduct ncbigene:609156
LEP GeneProduct ncbigene:403616
RETN GeneProduct ncbigene:611540
CFD GeneProduct ncbigene:485095
GTF3A GeneProduct ncbigene:477329
RB1 GeneProduct ncbigene:476915
RBL2 GeneProduct ncbigene:478127
ADIPOQ GeneProduct ncbigene:403625
ADFP GeneProduct ncbigene:474720
AGT GeneProduct ncbigene:403783
CDKN1A GeneProduct ncbigene:474890
E2F1 GeneProduct ncbigene:485839
SP1 GeneProduct ncbigene:486507
HMGA1 GeneProduct ncbigene:442946
PLIN GeneProduct ncbigene:488735
IL6 GeneProduct ncbigene:403985
GADD45B GeneProduct ncbigene:485069
CEBPD GeneProduct ncbigene:606783
BMP1 GeneProduct ncbigene:486127
BMP2 GeneProduct ncbigene:477162
BMP3 GeneProduct ncbigene:487826
BMP4 GeneProduct ncbigene:490695
NDN GeneProduct ncbigene:488693
FOXO1 GeneProduct ncbigene:477295
KLF5 GeneProduct ncbigene:612788
FOXC2 GeneProduct ncbigene:489671
PPARGC1A GeneProduct ncbigene:479127
NCOA1 GeneProduct ncbigene:475684
NCOA2 GeneProduct ncbigene:486989
PPARA GeneProduct ncbigene:403654
STAT3 GeneProduct ncbigene:490967
STAT2 GeneProduct ncbigene:481111
STAT1 GeneProduct ncbigene:488449
STAT6 GeneProduct ncbigene:100142679
SOCS1 GeneProduct ncbigene:490006
SOCS3 GeneProduct ncbigene:442949
CNTFR GeneProduct ncbigene:442941
LIFR GeneProduct ncbigene:449478
IL6ST GeneProduct ncbigene:403545
MBNL1 GeneProduct ncbigene:477116
OSM GeneProduct ncbigene:611921
CTNNB1 GeneProduct ncbigene:477032
UCP1 GeneProduct ncbigene:403574
WNT5B GeneProduct ncbigene:486756
WNT1 GeneProduct ncbigene:486560
SMAD3 GeneProduct ncbigene:610902
FZD1 GeneProduct ncbigene:482294
DVL1 GeneProduct ncbigene:489593
HNF1A GeneProduct ncbigene:486303
RXRG GeneProduct ncbigene:478989
INS GeneProduct ncbigene:483665
NAMPT GeneProduct ncbigene:483267
SPOCK1 GeneProduct ncbigene:474688
TRIB3 GeneProduct ncbigene:485819
GATA4 GeneProduct ncbigene:486079
NR2F1 GeneProduct ncbigene:488908
NRIP1 GeneProduct ncbigene:478385
RORA GeneProduct ncbigene:478328
PRLR GeneProduct ncbigene:479363
PNPLA3 GeneProduct ncbigene:609368
CUGBP1 GeneProduct ncbigene:475979
HIF1A GeneProduct ncbigene:480348
KLF6 GeneProduct ncbigene:487151
KLF7 GeneProduct ncbigene:478885
SFRP4 GeneProduct ncbigene:483258
NCOR1 GeneProduct ncbigene:479515
NCOR2 GeneProduct ncbigene:486242
KLF15 GeneProduct ncbigene:609067
EGR2 GeneProduct ncbigene:479219
EBF1 GeneProduct ncbigene:479312
EPAS1 GeneProduct ncbigene:474578
AHR GeneProduct ncbigene:475251
CISD1 GeneProduct ncbigene:479212
WWTR1 GeneProduct ncbigene:609743
GDF10 GeneProduct ncbigene:611168
IRS1 GeneProduct ncbigene:486148
IRS4 GeneProduct ncbigene:492059
BSCL2 GeneProduct ncbigene:476054
LMNA GeneProduct ncbigene:480124
AGPAT2 GeneProduct ncbigene:491249
ZMPSTE24 GeneProduct ncbigene:482460
LPIN1 GeneProduct ncbigene:475670
LPIN2 GeneProduct ncbigene:607640
LIPE GeneProduct ncbigene:403607
PCK1 GeneProduct ncbigene:403560
PCK2 GeneProduct ncbigene:480255
IRS2 GeneProduct ncbigene:485548
LPIN3 GeneProduct ncbigene:485876
E2F4 GeneProduct ncbigene:611243

References

  1. Molecular regulation of adipogenesis. Rosen ED, Spiegelman BM. Annu Rev Cell Dev Biol. 2000;16:145–71. PubMed Europe PMC Scholia