S1P receptor signal transduction (WP1081)
Bos taurus
Metabolism of sphingomyelin by the sphingomyelinase, ceramidase (Cer'ase) and the sphingosine kinase (SK) enzymes results in formation of S1P and receptor activation. Autocrine and paracrine modes of receptor activation have been implied but have yet to be rigorously proven. Critical signaling molecules, such as phospholipase C (PLC), ERK, PI3K, and Akt are activated. Active Akt binds to the receptor and phosphorylates the third intracellular loop, which is essential for Rac activation.
Authors
Martina Summer-Kutmon and Eric WeitzActivity
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Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
sphingosine 1-phosphate signaling pathway G protein mediated signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| SPHK1 | GeneProduct | ensembl:ENSBTAG00000008507 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8877 |
| SPHK2 | GeneProduct | ensembl:ENSBTAG00000009872 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:56848 |
| ASAH1 | GeneProduct | ensembl:ENSBTAG00000011257 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:427 |
| SMPD2 | GeneProduct | ensembl:ENSBTAG00000008145 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6610 |
| S1PR1 | GeneProduct | ensembl:ENSBTAG00000005990 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1901 |
| S1PR2 | GeneProduct | ensembl:ENSBTAG00000002738 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9294 |
| S1PR3 | GeneProduct | ensembl:ENSBTAG00000011374 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1903 |
| S1PR5 | GeneProduct | ensembl:ENSBTAG00000003544 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:53637 |
| PLCB1 | GeneProduct | ensembl:ENSBTAG00000008338 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23236 |
| PLCB2 | GeneProduct | ensembl:ENSBTAG00000019079 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5330 |
| PLCB3 | GeneProduct | ensembl:ENSBTAG00000012510 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5331 |
| MAPK3 | GeneProduct | ensembl:ENSBTAG00000016156 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595 |
| MAPK1 | GeneProduct | ensembl:ENSBTAG00000010312 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594 |
| MAPK6 | GeneProduct | ensembl:ENSBTAG00000005865 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5597 |
| MAPK4 | GeneProduct | ensembl:ENSBTAG00000009907 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5596 |
| MAPK7 | GeneProduct | ensembl:ENSBTAG00000001014 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5598 |
| MAPK12 | GeneProduct | ensembl:ENSBTAG00000019574 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6300 |
| GNAI1 | GeneProduct | ensembl:ENSBTAG00000002714 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2770 |
| GNAI2 | GeneProduct | ensembl:ENSBTAG00000020645 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2771 |
| GNAI3 | GeneProduct | ensembl:ENSBTAG00000013016 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2773 |
| AKT1 | GeneProduct | ensembl:ENSBTAG00000017636 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207 |
| AKT2 | GeneProduct | ensembl:ENSBTAG00000001400 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:208 |
| AKT3 | GeneProduct | ensembl:ENSBTAG00000017788 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10000 |
| PIK3C2B | GeneProduct | ensembl:ENSBTAG00000024633 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5287 |
| RACGAP1 | GeneProduct | ensembl:ENSBTAG00000012784 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:29127 |
References
- Lysophospholipids--receptor revelations. Hla T, Lee MJ, Ancellin N, Paik JH, Kluk MJ. Science. 2001 Nov 30;294(5548):1875–8. PubMed Europe PMC Scholia