Type II interferon signaling (IFNG) (WP1017)
Bos taurus
Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]
Authors
Martina Summer-KutmonActivity
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Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
type II interferon signaling pathway Jak-Stat signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| IFNG | GeneProduct | ensembl:ENSBTAG00000012529 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3458 |
| IFNGR1 | GeneProduct | ensembl:ENSBTAG00000012544 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3459 |
| IFNGR2 | GeneProduct | ensembl:ENSBTAG00000012899 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3460 |
| JAK1 | GeneProduct | ensembl:ENSBTAG00000003147 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3716 |
| JAK2 | GeneProduct | ensembl:ENSBTAG00000012047 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717 |
| SOCS3 | GeneProduct | ensembl:ENSBTAG00000008441 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9021 |
| SOCS1 | GeneProduct | ensembl:ENSBTAG00000004386 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8651 |
| PTPN11 | GeneProduct | ensembl:ENSBTAG00000002048 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5781 |
| STAT1 | GeneProduct | ensembl:ENSBTAG00000007867 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6772 |
| STAT2 | GeneProduct | ensembl:ENSBTAG00000004380 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6773 |
| PRKCD | GeneProduct | ensembl:ENSBTAG00000008719 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5580 |
| IRF4 | GeneProduct | ensembl:ENSBTAG00000002929 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3662 |
| SPI1 | GeneProduct | ensembl:ENSBTAG00000021709 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6688 |
| INFAF | GeneProduct | ensembl:ENSBTAG00000046824 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3440 |
| IL6 | GeneProduct | ensembl:ENSBTAG00000046456 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3456 |
| HLA-B | GeneProduct | ensembl:ENSBTAG00000038619 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3106 |
| INOS | GeneProduct | ensembl:ENSBTAG00000006894 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4843 |
| GBP1 | GeneProduct | ensembl:ENSBTAG00000001143 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2633 |
| PSMB9 | GeneProduct | ensembl:ENSBTAG00000008954 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5698 |
| TAP1 | GeneProduct | ensembl:ENSBTAG00000008953 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6890 |
| OAS1Y | GeneProduct | ensembl:ENSBTAG00000039861 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4938 |
| CXCL10 | GeneProduct | ensembl:ENSBTAG00000001725 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3627 |
| CIITA | GeneProduct | ensembl:ENSBTAG00000020649 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4261 |
| CYBB | GeneProduct | ensembl:ENSBTAG00000019953 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1536 |
| IL1B | GeneProduct | ensembl:ENSBTAG00000001321 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553 |
| IFIT2 | GeneProduct | ensembl:ENSBTAG00000034918 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3433 |
| EIF2AK2 | GeneProduct | ensembl:ENSBTAG00000008703 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5610 |
| IFI6 | GeneProduct | ensembl:ENSBTAG00000007554 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2537 |
| IRF1 | GeneProduct | ensembl:ENSBTAG00000031231 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3659 |
| ICAM1 | GeneProduct | ensembl:ENSBTAG00000010303 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3383 |
| CXCL9 | GeneProduct | ensembl:ENSBTAG00000038639 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4283 |
| ISG15 | GeneProduct | ensembl:ENSBTAG00000014707 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9636 |
| IRF8 | GeneProduct | ensembl:ENSBTAG00000017824 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3394 |
| IRF2 | GeneProduct | ensembl:ENSBTAG00000010002 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3660 |
References
- A logic-based diagram of signalling pathways central to macrophage activation. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, et al. BMC Syst Biol. 2008 Apr 23;2:36. PubMed Europe PMC Scholia