estrogen signalling (Homo sapiens)
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Description
Estrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.
Bibliography
- Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC; ''Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.; ''J Leukoc Biol, 2008 - PubMed
- Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E; ''IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.; ''Proc Natl Acad Sci U S A, 2006 - PubMed
- Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J; ''TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.; ''J Biol Chem, 2006 - PubMed
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Pathway Info
DataNodes
| View all 30 DataNodes |
| Name | Type | Backpage Header | Database reference |
|---|---|---|---|
| C-FOS | GeneProduct | 2353 (Entrez Gene) | |
| MAPKKK | GeneProduct | 673 (Entrez Gene) | |
| SP1 | GeneProduct | 6667 (Entrez Gene) | |
| Cyclic AMP | Metabolite | 6076 (PubChem) | |
| ERE | GeneProduct | 2099 (Entrez Gene) |
