Calcium Regulation in the Cardiac Cell (Homo sapiens)

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Description

Calcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resulting from activation of ion channels or as a second messenger caused by indirect signal transduction pathways such as G protein-coupled receptors. Movement of calcium ions from the extracellular compartment to the intracellular compartment alters membrane depolarisation. This is seen in the heart, during the plateau phase of ventricular contraction. In this example, calcium acts to maintain depolarisation of the heart.

Source: Wikipedia


Bibliography

  1. Marks AR; ''Calcium and the heart: a question of life and death.; ''J Clin Invest, 2003 - PubMed

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37305view16:49, 26 May 2010AmcuserPeriodical save, work in progress
35441view11:38, 12 February 2010Thomasadded literature
35439view11:36, 12 February 2010ThomasModified description
34462view18:27, 10 December 2009MaintBotAutomatic update of empty xrefs
32461view17:26, 15 August 2009MaintBotFixed text labels
32144view13:59, 14 August 2009MaintBotFixed group labels
21808view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Calcium regulation in cardiac cells]] moved to [[Pathway:WP536]]: Moved to stable identifier
15237view10:39, 26 May 2008Thomaslinked lines
15235view10:31, 26 May 2008ThomasPeriodical save, work in progress
14301view11:44, 22 May 2008SusanAdded connections
14147view15:03, 21 May 2008SusanGroupin of genes
13046view11:11, 17 May 2008MaintBotautomated metabolite conversion
12997view11:00, 17 May 2008MaintBotSticky edges patch by Sjoerd
7932view13:46, 7 January 2008MaintBot[[Pathway:Human:Calcium regulation in cardiac cells]] moved to [[Pathway:Homo sapiens:Calcium regulation in cardiac cells]]: Renaming species
7591view16:02, 18 December 2007MaintBotfixed category names
7458view12:42, 4 November 2007MaintBotAdded categories to GPML
19391view22:17, 22 May 2007N.Cottegpml file for [[Human:Calcium_regulation_in_cardiac_cells]]
19388view22:17, 22 May 2007J.Fonggpml file for [[Human:Calcium_regulation_in_cardiac_cells]]
6299view22:17, 22 May 2007Nsalomonisgpml file for [[Human:Calcium_regulation_in_cardiac_cells]]

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