Common Pathways Underlying Drug Addiction (Homo sapiens)
The pathway was modeled after Figure 2 in Li, et al. 2008 and is based on the common pathways identified in their study as well as protein interaction data. Specifically, glutamate and dopamine neuroactive ligand-receptor interactions trigger long-term potentiation, MAPK and GnRH signaling and gap junction regulation (green outlined pathway nodes). Related functional modules such as depolarization, gene expression and cytoskeleton regulation are also indicated (non-outlined pathway nodes). Among the several positive feedback loops identified in this pathway, the authors highlighted fast and slow ones in red and blue, respectively.
- Li CY, Mao X, Wei L; ''Genes and (common) pathways underlying drug addiction.''; PLoS Comput Biol, 2008 PubMed
No annotated interactions